Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

(2014) Srdjan Maksimovic et al.   NATURE

Piezo2 is required for Merkel-cell mechanotransduction

(2014) Seung-Hyun Woo et al.   NATURE

Muscarinic acetylcholine receptors: novel opportunities for drug development

(2014) Andrew C. Kruse et al.   NATURE REVIEWS DRUG DISCOVERY

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human PIEZO1: Removing Inactivation

(2013) Chilman Bae et al.   BIOPHYSICAL JOURNAL

Mechano-Gated Ion Channels in Sensory Systems

(2013) Patrick Delmas et al.   CELL

Promiscuous Activation of Transient Receptor Potential Vanilloid 1 (TRPV1) Channels by Negatively Charged Intracellular Lipids

(2013) Viktor Lukacs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenotyping the Function of TRPV1-Expressing Sensory Neurons by Targeted Axonal Silencing

(2013) C. Brenneis et al.   JOURNAL OF NEUROSCIENCE

Distinctive Changes in Plasma Membrane Phosphoinositides Underlie Differential Regulation of TRPV1 in Nociceptive Neurons

(2013) V. Lukacs et al.   JOURNAL OF NEUROSCIENCE

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis

(2013) B. Coste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1

(2013) C. Bae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for Piezo2 in EPAC1-dependent mechanical allodynia

(2013) N Eijkelkamp et al.   Nature Communications

Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

(2012) R. Zarychanski et al.   BLOOD

Piezo1

(2012) Philip A. Gottlieb et al.   Channels

Gating the mechanical channel Piezo1

(2012) Philip A. Gottlieb et al.   Channels

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

The role of Drosophila Piezo in mechanical nociception

(2012) Sung Eun Kim et al.   NATURE

PI4P and PI(4,5)P2 Are Essential But Independent Lipid Determinants of Membrane Identity

(2012) G. R. V. Hammond et al.   SCIENCE

Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents

(2012) Adrienne E. Dubin et al.   Cell Reports

The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4

(2011) Chilman Bae et al.   BIOCHEMISTRY

Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5)P2

(2011) Eleonora Zakharian et al.   FASEB JOURNAL

Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells

(2011) D. J. Cavanaugh et al.   JOURNAL OF NEUROSCIENCE

Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels

(2011) Yevgen Yudin et al.   JOURNAL OF PHYSIOLOGY-LONDON

TRPV1-lineage neurons are required for thermal sensation

(2010) Santosh K Mishra et al.   EMBO JOURNAL

Pressing and squeezing with Piezos

(2010) Bernd Nilius   EMBO REPORTS

Gating of Transient Receptor Potential Melastatin 8 (TRPM8) Channels Activated by Cold and Chemical Agonists in Planar Lipid Bilayers

(2010) E. Zakharian et al.   JOURNAL OF NEUROSCIENCE

Regulation of the Actin Cytoskeleton-Plasma Membrane Interplay by Phosphoinositides

(2010) Juha Saarikangas et al.   PHYSIOLOGICAL REVIEWS

Stretch-Activated Ion Channels: What Are They?

(2010) Frederick Sachs   PHYSIOLOGY

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Biophysics and Structure of the Patch and the Gigaseal

(2009) Thomas M. Suchyna et al.   BIOPHYSICAL JOURNAL

Kinetic properties of mechanically activated currents in spinal sensory neurons

(2009) François Rugiero et al.   JOURNAL OF PHYSIOLOGY-LONDON

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

(2008) Byung-Chang Suh et al.   Annual Review of Biophysics

Tunable Calcium Current through TRPV1 Receptor Channels

(2008) Damien S. K. Samways et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monitoring changes in membrane phosphatidylinositol 4,5-bisphosphate in living cells using a domain from the transcription factor tubby

(2008) Kathryn V. Quinn et al.   JOURNAL OF PHYSIOLOGY-LONDON

Local application of capsaicin alleviates mechanical hyperalgesia after spinal nerve transection

(2008) Sung Min Kim et al.   NEUROSCIENCE LETTERS

Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators

(2008) Yuji Karashima et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Maintenance of Hormone-sensitive Phosphoinositide Pools in the Plasma Membrane Requires Phosphatidylinositol 4-Kinase IIIα

(2007) Andras Balla et al.   MOLECULAR BIOLOGY OF THE CELL