High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites
出版年份 2019 全文链接
标题
High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites
作者
关键词
-
出版物
Scientific Reports
Volume 9, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-05-08
DOI
10.1038/s41598-019-42801-x
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Extending the Compatibility of the SP3 Paramagnetic Bead Processing Approach for Proteomics
- (2018) Sophie Moggridge et al. JOURNAL OF PROTEOME RESEARCH
- Uncovering the essential genes of the human malaria parasitePlasmodium falciparumby saturation mutagenesis
- (2018) Min Zhang et al. SCIENCE
- Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG)
- (2018) Denise J. Tsagris et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Small molecule–based inhibition of MEK1/2 proteins dampens inflammatory responses to malaria, reduces parasite load, and mitigates pathogenic outcomes
- (2017) Xianzhu Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia
- (2017) Angana Mukherjee et al. MALARIA JOURNAL
- Screening a protein kinase inhibitor library against Plasmodium falciparum
- (2017) Irene Hallyburton et al. MALARIA JOURNAL
- Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
- (2017) Tanya Paquet et al. Science Translational Medicine
- A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission
- (2017) David A. Baker et al. Nature Communications
- Cyclic nucleotide signalling in malaria parasites
- (2017) David A. Baker et al. Open Biology
- The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites
- (2017) L. Dembele et al. Scientific Reports
- 5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents
- (2016) Wenlin Huang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Invasion of hepatocytes byPlasmodiumsporozoites requires cGMP-dependent protein kinase and calcium dependent protein kinase 4
- (2016) K. Govindasamy et al. MOLECULAR MICROBIOLOGY
- Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds
- (2016) Gregory J. Crowther et al. PLoS One
- Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development
- (2015) Judith L. Green et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Molecular Property Design: Does Everyone Get It?
- (2015) Paul D. Leeson et al. ACS Medicinal Chemistry Letters
- Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion
- (2015) Mahmood M. Alam et al. Nature Communications
- New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource
- (2015) Imanol Peña et al. Scientific Reports
- Phosphatidylinositol 3-Kinase γ Is Required for the Development of Experimental Cerebral Malaria
- (2015) Norinne Lacerda-Queiroz et al. PLoS One
- Ion Coalescence of Neutron Encoded TMT 10-Plex Reporter Ions
- (2014) Thilo Werner et al. ANALYTICAL CHEMISTRY
- A Male and Female Gametocyte Functional Viability Assay To Identify Biologically Relevant Malaria Transmission-Blocking Drugs
- (2014) A. Ruecker et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors
- (2014) Matthew D. Falk et al. BIOSCIENCE REPORTS
- Dose Selection, Pharmacokinetics, and Pharmacodynamics of BRAF Inhibitor Dabrafenib (GSK2118436)
- (2014) G. S. Falchook et al. CLINICAL CANCER RESEARCH
- High proportion of knowlesi malaria in recent malaria cases in Malaysia
- (2014) Ruhani Yusof et al. MALARIA JOURNAL
- Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum
- (2014) Vicky M Avery et al. MALARIA JOURNAL
- Ultrasensitive proteome analysis using paramagnetic bead technology
- (2014) C. S. Hughes et al. Molecular Systems Biology
- Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites
- (2014) Mathieu Brochet et al. PLOS BIOLOGY
- Male and Female Plasmodium falciparum Mature Gametocytes Show Different Responses to Antimalarial Drugs
- (2013) Michael J. Delves et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors
- (2013) Tara R. Rheault et al. ACS Medicinal Chemistry Letters
- Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress
- (2013) Christine R. Collins et al. PLoS Pathogens
- High-Resolution Enabled TMT 8-plexing
- (2012) Thilo Werner et al. ANALYTICAL CHEMISTRY
- A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation
- (2012) Giovanna Bergamini et al. Nature Chemical Biology
- Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
- (2011) Marcus Bantscheff et al. NATURE BIOTECHNOLOGY
- Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery
- (2011) S. Meister et al. SCIENCE
- Thousands of chemical starting points for antimalarial lead identification
- (2010) Francisco-Javier Gamo et al. NATURE
- Chemical genetics of Plasmodium falciparum
- (2010) W. Armand Guiguemde et al. NATURE
- A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes
- (2010) J. D. Dvorin et al. SCIENCE
- Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis
- (2009) Danzhi Huang et al. BIOINFORMATICS
- The Malaria Parasite Cyclic GMP-Dependent Protein Kinase Plays a Central Role in Blood-Stage Schizogony
- (2009) Helen M. Taylor et al. EUKARYOTIC CELL
- Role of Plasmodium berghei cGMP-dependent Protein Kinase in Late Liver Stage Development
- (2009) Adebola Falae et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Artemisinin-Resistant Malaria in Asia
- (2009) Harald Noedl et al. NEW ENGLAND JOURNAL OF MEDICINE
- Artemisinin Resistance inPlasmodium falciparumMalaria
- (2009) Arjen M. Dondorp et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Cyclic GMP Signalling Module That Regulates Gliding Motility in a Malaria Parasite
- (2009) Robert W. Moon et al. PLoS Pathogens
- Gametogenesis in Malaria Parasites Is Mediated by the cGMP-Dependent Protein Kinase
- (2008) Louisa McRobert et al. PLOS BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now