标题
A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation
作者
关键词
-
出版物
Nature Chemical Biology
Volume 8, Issue 6, Pages 576-582
出版商
Springer Nature
发表日期
2012-04-30
DOI
10.1038/nchembio.957
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Delayed Fragmentation and Optimized Isolation Width Settings for Improvement of Protein Identification and Accuracy of Isobaric Mass Tag Quantification on Orbitrap-Type Mass Spectrometers
- (2011) Mikhail M. Savitski et al. ANALYTICAL CHEMISTRY
- PI3Kγ Mediates Kaposi's Sarcoma-Associated Herpesvirus vGPCR-Induced Sarcomagenesis
- (2011) Daniel Martin et al. CANCER CELL
- Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression
- (2011) Michael C. Schmid et al. CANCER CELL
- PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation
- (2011) Sarah Haylock-Jacobs et al. JOURNAL OF AUTOIMMUNITY
- Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
- (2011) Marcus Bantscheff et al. NATURE BIOTECHNOLOGY
- A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
- (2011) Luis I Toledo et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance
- (2011) N. Kobayashi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PI3K within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance
- (2011) B. Becattini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Evaluation of Data Analysis Strategies for Improved Mass Spectrometry-Based Phosphoproteomics
- (2010) Mikhail M. Savitski et al. ANALYTICAL CHEMISTRY
- LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study
- (2010) M. C. Genovese et al. ARTHRITIS AND RHEUMATISM
- PI3K inhibition in inflammation: Toward tailored therapies for specific diseases
- (2010) Alessandra Ghigo et al. BIOESSAYS
- Discovery of Dual Inhibitors of the Immune Cell PI3Ks p110δ and p110γ: a Prototype for New Anti-inflammatory Drugs
- (2010) Olusegun Williams et al. CHEMISTRY & BIOLOGY
- Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90
- (2010) Patrick Fadden et al. CHEMISTRY & BIOLOGY
- Targeted data acquisition for improved reproducibility and robustness of proteomic mass spectrometry assays
- (2010) Mikhail M. Savitski et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells
- (2010) U Kruse et al. LEUKEMIA
- The emerging mechanisms of isoform-specific PI3K signalling
- (2010) Bart Vanhaesebroeck et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Proinflammatory T helper type 17 cells are effective B-cell helpers
- (2010) M. Mitsdoerffer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Blockade Is an Effective Radiosensitizing Strategy for the Treatment of Non-Small Cell Lung Cancer Harboring K-RAS Mutations
- (2009) G. Konstantinidou et al. CANCER RESEARCH
- Infliximab treatment reduces the serum levels of interleukin-23 in patients with rheumatoid arthritis
- (2009) Yasunori Kageyama et al. Modern Rheumatology
- Proteomics strategy for quantitative protein interaction profiling in cell extracts
- (2009) Kirti Sharma et al. NATURE METHODS
- Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells
- (2009) Saskia M. Brachmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PI3K Adaptor Subunits Define Coupling to Degranulation and Cell Motility by Distinct PtdIns(3,4,5)P3 Pools in Mast Cells
- (2009) T. Bohnacker et al. Science Signaling
- Chemical target and pathway toxicity mechanisms defined in primary human cell systems
- (2009) Ellen L. Berg et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Genetic and Pharmacological Targeting of Phosphoinositide 3-Kinase-γ Reduces Atherosclerosis and Favors Plaque Stability by Modulating Inflammatory Processes
- (2008) Anne Fougerat et al. CIRCULATION
- A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding
- (2008) Harold B J Jefferies et al. EMBO REPORTS
- Phosphoinositide 3-Kinases γ and δ, Linkers of Coordinate C5a Receptor-Fcγ Receptor Activation and Immune Complex-induced Inflammation
- (2008) Stephanie Konrad et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
- (2008) S.-M. Maira et al. MOLECULAR CANCER THERAPEUTICS
- Phosphoinositide 3-Kinase p110 Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development
- (2008) E. Ciraolo et al. Science Signaling
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More