TCF7L2 regulates pancreatic β-cell function through PI3K/AKT signal pathway

A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart

(2018) Lavanya M Iyer et al.   NUCLEIC ACIDS RESEARCH

Interrelationship of the rs7903146 TCF7L2 gene variant with measures of glucose metabolism and adiposity: The NEO study

(2018) R. Noordam et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer

(2018) Jinfeng Xiang et al.   Cell Death & Disease

The Wnt Signaling Pathway Effector TCF7L2 Mediates Olanzapine-Induced Weight Gain and Insulin Resistance

(2018) Ranran Li et al.   Frontiers in Pharmacology

The PI3K/AKT pathway in obesity and type 2 diabetes

(2018) Xingjun Huang et al.   International Journal of Biological Sciences

Transcription factor 7-like 2 (TCF7L2) gene polymorphisms are strong predictorsof type 2 diabetes among nonobese diabetics in the Turkish population

(2017) Dudu ERKOÇ KAYA et al.   Turkish Journal Of Medical Sciences

Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population

(2017) Mauren Isfer Anghebem-Oliveira et al.   Archives of Endocrinology Metabolism

The TCF7L2 rs7903146 (C/T) polymorphism is associated with risk to type 2 diabetes mellitus in Southern-Brazil

(2017) Taís S. Assmann et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

A novel formula Sang-Tong-Jian improves glycometabolism and ameliorates insulin resistance by activating PI3K/AKT pathway in type 2 diabetic KKAy mice

(2016) Meiyu Kuai et al.   BIOMEDICINE & PHARMACOTHERAPY

Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

(2016) Jason S. L. Yu et al.   DEVELOPMENT

Hypoglycemic effect of D-chiro-inositol in type 2 diabetes mellitus rats through the PI3K/Akt signaling pathway

(2016) Yun-feng Gao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Geniposide promotes beta-cell regeneration and survival through regulating β-catenin/TCF7L2 pathway

(2015) D D Yao et al.   Cell Death & Disease

Beyond association: A functional role for Tcf7l2 in β-cell development

(2015) Adriana Migliorini et al.   Molecular Metabolism

The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis

(2015) Weijuan Shao et al.   Molecular Metabolism

p85  deficiency protects  -cells from endoplasmic reticulum stress-induced apoptosis

(2014) J. N. Winnay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective

(2012) Wilfred Ip et al.   Cell and Bioscience

Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism

(2011) L. Norton et al.   DIABETOLOGIA

Molecular Function of TCF7L2: Consequences of TCF7L2 Splicing for Molecular Function and Risk for Type 2 Diabetes

(2010) Ola Hansson et al.   Current Diabetes Reports

Disease-associated loci are significantly over-represented among genes bound by transcription factor 7-like 2 (TCF7L2) in vivo

(2010) J. Zhao et al.   DIABETOLOGIA

Overcoming remyelination failure in multiple sclerosis and other myelin disorders

(2010) Stephen P.J. Fancy et al.   EXPERIMENTAL NEUROLOGY

TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet  -Cells

(2009) G. da Silva Xavier et al.   DIABETES

ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes

(2009) A. A. Margolin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Pattern of TCF7L2/TCF4 Chromatin Occupancy in Colorectal Cancer Cells

(2008) P. Hatzis et al.   MOLECULAR AND CELLULAR BIOLOGY