Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness
出版年份 2019 全文链接
标题
Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness
作者
关键词
-
出版物
Nature Communications
Volume 10, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-06-28
DOI
10.1038/s41467-019-10705-z
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Identification of genes functionally involved in the detrimental effects of mutant histone H3.3-K27M in Drosophila melanogaster
- (2019) Johannes Berlandi et al. NEURO-ONCOLOGY
- EZH2 mutations in chronic myelomonocytic leukemia cluster with ASXL1 mutations and their co-occurrence is prognostically detrimental
- (2018) Mrinal M. Patnaik et al. Blood Cancer Journal
- Clinical Outcomes and Co-Occurring Mutations in Patients with RUNX1-Mutated Acute Myeloid Leukemia
- (2017) Maliha Khan et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG
- (2017) Francisco J. Cordero et al. MOLECULAR CANCER RESEARCH
- Tracing the origins of relapse in acute myeloid leukaemia to stem cells
- (2017) Liran I. Shlush et al. NATURE
- EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas
- (2017) Faizaan Mohammad et al. NATURE MEDICINE
- Clonal hematopoiesis
- (2017) Max Jan et al. SEMINARS IN HEMATOLOGY
- Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel
- (2016) Hartmut Döhner et al. BLOOD
- Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia
- (2016) K. H. Metzeler et al. BLOOD
- RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features
- (2016) V I Gaidzik et al. LEUKEMIA
- Analysis of protein-coding genetic variation in 60,706 humans
- (2016) Monkol Lek et al. NATURE
- Emerging concepts of epigenetic dysregulation in hematological malignancies
- (2016) Panagiotis Ntziachristos et al. NATURE IMMUNOLOGY
- S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3
- (2016) Hariharan Jayaram et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
- (2016) C. Lu et al. SCIENCE
- Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
- (2016) Hamid Nikbakht et al. Nature Communications
- Epigenetic aberrations in acute myeloid leukemia: Early key events during leukemogenesis
- (2015) Anna Eriksson et al. EXPERIMENTAL HEMATOLOGY
- EZH2 in normal hematopoiesis and hematological malignancies
- (2015) Laurie Herviou et al. Oncotarget
- Trimmomatic: a flexible trimmer for Illumina sequence data
- (2014) Anthony M. Bolger et al. BIOINFORMATICS
- Acute myeloid leukemia ontogeny is defined by distinct somatic mutations
- (2014) R. C. Lindsley et al. BLOOD
- Reduced Lymphoid Lineage Priming Promotes Human Hematopoietic Stem Cell Expansion
- (2014) Peter van Galen et al. Cell Stem Cell
- The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress
- (2014) Peter van Galen et al. NATURE
- Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
- (2014) Liran I. Shlush et al. NATURE
- Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma
- (2014) Adam M Fontebasso et al. NATURE GENETICS
- Age-related mutations associated with clonal hematopoietic expansion and malignancies
- (2014) Mingchao Xie et al. NATURE MEDICINE
- Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
- (2014) Giulio Genovese et al. NEW ENGLAND JOURNAL OF MEDICINE
- Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
- (2014) Siddhartha Jaiswal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission
- (2014) M. R. Corces-Zimmerman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling
- (2014) H.-M. Herz et al. SCIENCE
- Low frequency of H3.3 mutations and upregulated DAXX expression in MDS
- (2013) Y. Attieh et al. BLOOD
- Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
- (2013) Sebastian Bender et al. CANCER CELL
- Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone
- (2013) Sam Behjati et al. NATURE GENETICS
- Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
- (2013) P. W. Lewis et al. SCIENCE
- Comprehensive Analysis of Transcriptome Variation Uncovers Known and Novel Driver Events in T-Cell Acute Lymphoblastic Leukemia
- (2013) Zeynep Kalender Atak et al. PLoS Genetics
- K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
- (2012) Dong-Anh Khuong-Quang et al. ACTA NEUROPATHOLOGICA
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma
- (2012) Dominik Sturm et al. CANCER CELL
- Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
- (2012) Jeremy Schwartzentruber et al. NATURE
- Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
- (2012) Gang Wu et al. NATURE GENETICS
- Clonal Architecture of Secondary Acute Myeloid Leukemia
- (2012) Matthew J. Walter et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mutation Patterns of 16 Genes in Primary and Secondary Acute Myeloid Leukemia (AML) with Normal Cytogenetics
- (2012) Marta Fernandez-Mercado et al. PLoS One
- Clonal Evolution of Preleukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia
- (2012) M. Jan et al. Science Translational Medicine
- Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms
- (2011) O Abdel-Wahab et al. LEUKEMIA
- Cytarabine Dose for Acute Myeloid Leukemia
- (2011) Bob Löwenberg et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
- (2010) A. McKenna et al. GENOME RESEARCH
- A map of human genome variation from population-scale sequencing
- (2010) Richard M. Durbin et al. NATURE
- ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
- (2010) K. Wang et al. NUCLEIC ACIDS RESEARCH
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
- Fast and accurate short read alignment with Burrows-Wheeler transform
- (2009) H. Li et al. BIOINFORMATICS
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