The therapeutic potential of chemical chaperones in protein folding diseases

Anti-Prion Activity of a Panel of Aromatic Chemical Compounds: In Vitro and In Silico Approaches

(2014) Natalia C. Ferreira et al.   PLoS One

4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor

(2013) Seisuke Mimori et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phenylbutyrate is a Multifaceted Drug that Exerts Neuroprotective Effects and Reverses the Alzheimer´s Disease-like Phenotype of a Commonly Used Mouse Model

(2013) Mar Cuadrado-Tejedor et al.   CURRENT PHARMACEUTICAL DESIGN

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Protein rescue from aggregates by powerful molecular chaperone machines

(2013) Shannon M. Doyle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Perspectives on molecular targeted therapies and clinical trials for neurodegenerative diseases

(2012) Masahisa Katsuno et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice

(2012) Ana F. Nunes et al.   MOLECULAR NEUROBIOLOGY

Tauroursodeoxycholic Acid Prevents MPTP-Induced Dopaminergic Cell Death in a Mouse Model of Parkinson’s Disease

(2012) M. Castro-Caldas et al.   MOLECULAR NEUROBIOLOGY

Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease

(2012) Avik Roy et al.   PLoS One

Epigenetic histone acetylation and deacetylation mechanisms in experimental models of neurodegenerative disorders

(2012) Zacharoula Konsoula et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice

(2011) Jesse C. Wiley et al.   AGING CELL

Structure–function analysis of the tertiary bile acid TUDCA for the resolution of endoplasmic reticulum stress in intestinal epithelial cells

(2011) Emanuel Berger et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cholesterol-derived bile acids enhance the chaperone activity of α-crystallins

(2011) Shuhua Song et al.   CELL STRESS & CHAPERONES

Defining the Mechanism of Action of 4-Phenylbutyrate to Develop a Small-Molecule-Based Therapy for Alzheimers Disease

(2011) M. Cuadrado-Tejedor et al.   CURRENT MEDICINAL CHEMISTRY

Phenylbutyrate Up-regulates the DJ-1 Protein and Protects Neurons in Cell Culture and in Animal Models of Parkinson Disease

(2011) Wenbo Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid beta-HSP60 peptide conjugate vaccine treats a mouse model of Alzheimer's disease

(2011) Anna Nemirovsky et al.   VACCINE

Phenylbutyric Acid Rescues Endoplasmic Reticulum Stress-Induced Suppression of APP Proteolysis and Prevents Apoptosis in Neuronal Cells

(2010) Jesse C. Wiley et al.   PLoS One

Tauroursodeoxycholic acid prevents E22Q Alzheimer’s Aβ toxicity in human cerebral endothelial cells

(2009) R. J. S. Viana et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Bile acids as regulatory molecules

(2009) Phillip B. Hylemon et al.   JOURNAL OF LIPID RESEARCH

Phase 2 study of sodium phenylbutyrate in ALS

(2008) Merit E. Cudkowicz et al.   Amyotrophic Lateral Sclerosis

Variety of Antiprion Compounds Discovered through an In Silico Screen Based on Cellular-Form Prion Protein Structure: Correlation between Antiprion Activity and Binding Affinity

(2008) J. Hosokawa-Muto et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy

(2008) Bárbara Macedo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease

(2008) Rita M. Ramalho et al.   TRENDS IN MOLECULAR MEDICINE