Article
Nutrition & Dietetics
Carlijn A. Wagenaar, Louise H. Dekker, Gerjan J. Navis
Summary: The study assessed the prevalence and determinants of sarcopenic obesity (SO) and sarcopenia in overweight (SOW) in a general population, finding higher prevalence of SOW and SO in females across all age groups, with age being a significant determinant of both conditions. Subjects over 70 years old accounted for 82.5% and 80.4% of SO and SOW patients, respectively.
CLINICAL NUTRITION
(2021)
Article
Chemistry, Multidisciplinary
Piao Wang, Yi Liu, Tong Zhang, Cheng Yin, Seok Yong Kang, Su Jin Kim, Yong-Ki Park, Hyo Won Jung
Summary: In this study, the root extract of Morinda officinalis (MORE) was found to improve diabetes symptoms in mice with high-fat-diet (HFD)/streptozotocin (STZ)-induced diabetes by enhancing muscle function. This suggests that MORE could be used to prevent or treat diabetes along with muscle disorders.
Article
Cell Biology
Feng-Min Zhang, Hao-Fan Wu, Han-Ping Shi, Zhen Yu, Cheng-Le Zhuang
Summary: Sarcopenia is a systemic skeletal muscle disorder that often affects the elderly population and is more common in cancer patients. It not only changes body composition but also leads to increased complications, reduced treatment efficacy, and shortened survival.
AGEING RESEARCH REVIEWS
(2023)
Review
Geriatrics & Gerontology
Xiaowei Han, Muhammad Ashraf, Srinivas M. Tipparaju, Wanling Xuan
Summary: Sarcopenia is the age-related loss of skeletal muscle mass and strength, and Alzheimer's disease is the most common cause of dementia in elderly adults. The association between sarcopenia and Alzheimer's disease is still unclear, but understanding the mechanism of muscle-brain crosstalk during cognitive impairment may provide new insights and therapeutic approaches for combating cognitive decline and Alzheimer's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Geriatrics & Gerontology
Ashley D. Troutman, Eliott Arroyo, Elizabeth M. Sheridan, Duncan J. D'Amico, Peyton R. Brandt, Rachel Hinrichs, Xiwei Chen, Kenneth Lim, Keith G. Avin
Summary: This study evaluated skeletal muscle atrophy in preclinical and clinical models of chronic kidney disease (CKD). The results showed that muscle wasting was present in both preclinical and clinical studies, with the extent of atrophy potentially influenced by gender. Limitations in study design prevented conclusions about the extent of muscle loss and the impact of dialysis.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Biology
Hiroaki Eshima, Justin L. Shahtout, Piyarat Siripoksup, MacKenzie J. Pearson, Ziad S. Mahmassani, Patrick J. Ferrara, Alexis W. Lyons, John Alan Maschek, Alek D. Peterlin, Anthony R. P. Verkerke, Jordan M. Johnson, Anahy Salcedo, Jonathan J. Petrocelli, Edwin R. Miranda, Ethan J. Anderson, Sihem Boudina, Qitao Ran, James E. Cox, Micah J. Drummond, Katsuhiko Funai
Summary: ROS accumulation is a key characteristic of skeletal muscle atrophy. The role of ROS in the loss of muscle mass and strength is not clear. This study reveals that LOOH, a type of ROS, promotes muscle atrophy in a lysosomal-dependent manner. Inhibition of LOOH prevents muscle atrophy and weakness in both young and old mice, suggesting that LOOH-derived carbonyl stress mediates age- and disuse-induced muscle dysfunction.
Article
Geriatrics & Gerontology
Ji Hee Yu, Regina E. Y. Kim, Jin-Man Jung, So Young Park, Da Young Lee, Hyun Joo Cho, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Chol Shin, Nan Hee Kim
Summary: This study found that sarcopenia is associated with brain volume atrophy, especially in the parietal gray matter. Maintaining good muscle mass is important for brain health in middle-aged population.
Article
Biochemistry & Molecular Biology
Jong Hyeon Yoon, Seung-Min Lee, Younglang Lee, Min Ju Kim, Jae Won Yang, Jeong Yi Choi, Ju Yeon Kwak, Kwang-Pyo Lee, Yong Ryoul Yang, Ki -Sun Kwon
Summary: Alverine citrate (AC) has been identified as a potential therapeutic candidate for improving muscle weakness and sarcopenia by inhibiting atrophy signals and enhancing myoblast fusion. Its treatment showed positive effects on muscle mass and physical performance in aged and hindlimb-disused mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Lucas Fajardo, Phelipe Sanchez, Jerome Salles, Jean Paul Rigaudiere, Veronique Patrac, Sylvie Caspar-Bauguil, Camille Bergoglgio, Cedric Moro, Stephane Walrand, Olivier Le Bacquer
Summary: Inhibition of the endocannabinoid system (ECS) by RIM (10 mg/kg/day) was effective in reducing body fat and improving muscle function in obese aged mice.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Manuela Moriggi, Sara Belloli, Pietro Barbacini, Valentina Murtaj, Enrica Torretta, Linda Chaabane, Tamara Canu, Silvia Penati, Maria Luisa Malosio, Antonio Esposito, Cecilia Gelfi, Rosa Maria Moresco, Daniele Capitanio
Summary: The study revealed gender-specific responses to obesity in mice, with males showing various metabolic alterations while females exhibited activation of compensatory mechanisms. Bioinformatics analysis identified upstream molecules regulating pathways differently in males and females.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Xiangsheng Pang, Peng Zhang, Xiaoping Chen, Wenming Liu
Summary: This paper provides a comprehensive view of different types of muscle atrophy and emphasizes the role of the ubiquitin-proteasome pathway. By examining recent scholarly advancements, it explores the association between the ubiquitin-proteasome pathway and specific pathological conditions linked to muscle atrophy.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Antonio Michelucci, Chen Liang, Feliciano Protasi, Robert T. Dirksen
Summary: This review highlights the importance of Ca2+ signaling and ATP generation in skeletal muscle contraction and outlines the role of impaired Ca2+ handling, dysfunctional ROS/RNS production, and structural/functional alterations in CRUs and mitochondria in various muscle disorders. Understanding these processes is crucial for identifying potential therapeutic targets to prevent or reverse muscle dysfunction in aging and disease.
Article
Biochemistry & Molecular Biology
Ailma O. da Paixao, Anaysa Paola Bolin, Joao G. Silvestre, Alice Cristina Rodrigues
Summary: The saturated fatty acid palmitic acid negatively affects muscle tube diameter, fusion, and metabolism, which may be related to miR-206.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Eun Ju Lee, Syed Sayeed Ahmad, Jeong Ho Lim, Khurshid Ahmad, Sibhghatulla Shaikh, Yun-Sil Lee, Sang Joon Park, Jun O. Jin, Yong-Ho Lee, Inho Choi
Summary: The study found that FMOD inhibits muscle aging by negatively regulating MSTN gene expression or suppressing MSTN protein, while MSTN promotes muscle aging by positively regulating the expressions of Atrogin1, CD36, and PPAR gamma genes in muscle.
Article
Geriatrics & Gerontology
Hyun-Jun Kim, Seon-Wook Kim, Sang-Hoon Lee, Da-Woon Jung, Darren R. Williams
Summary: This study found that Alox5 is a regulator and drug target for muscle atrophy, and the drug malotilate can be repurposed as a treatment for muscle atrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Genetics & Heredity
Vaithinathan Selvaraju, Megan Phillips, Anna Fouty, Jeganathan Ramesh Babu, Thangiah Geetha
Summary: Disparities in health and disease between different races have been well documented in the USA. Recent studies have found that telomere length, a marker of aging, is associated with obesity and obesity-related diseases. This study showed that African American (AA) children have a significantly higher telomere to single copy gene ratio compared to European American (EA) children, and this high ratio is negatively correlated with diastolic pressure.
Article
Pediatrics
Priscilla Ayine, Vaithinathan Selvaraju, Chandra M. K. Venkatapoorna, Yida Bao, Philippe Gaillard, Thangiah Geetha
Summary: The study found that food responsiveness and emotional overeating were increased in obese children, influenced by maternal education level. Additionally, obese children showed significant differences in specific CEBQ factors, indicating a possible relationship between weight status and eating behaviors.
Review
Biochemistry & Molecular Biology
Priyadarshni Patel, Jeganathan Ramesh Babu, Xu Wang, Thangiah Geetha
Summary: Obesity is caused by a combination of hereditary and environmental factors. Despite efforts to find effective long-term solutions through diet, exercise, education, surgery, and pharmacological treatments, there has been no success. Recent advancements in epigenetics have increased public interest in understanding how diet and lifestyle choices influence an individual's health.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Article
Genetics & Heredity
Megan Phillips, Vaithinathan Selvaraju, Anna Fouty, Jeganathan Ramesh Babu, Maninder Sandey, Thangiah Geetha
Summary: The study found that the copy number of the 11q11 gene was significantly higher in girls compared to boys, and AA participants had more copies than EA participants. Both normal weight and overweight/obese girls were less likely to belong to the low copy number variant group of 11q11 compared to boys, and a similar trend was observed in AA children.
Article
Biochemistry & Molecular Biology
Vaithinathan Selvaraju, Jeganathan R. Babu, Thangiah Geetha
Summary: This study found that salivary levels of fetuin-A, insulin, and adiponectin are associated with obesity in elementary school-aged children. Fetuin-A and insulin are positively correlated with obesity measures, while adiponectin is inversely correlated.
Article
Medicine, General & Internal
Vaithinathan Selvaraju, Jeganathan R. Babu, Thangiah Geetha
Summary: Obesity is associated with inflammation, and neurotrophins BDNF and β-NGF play a role in energy homeostasis and food intake. This study found higher levels of BDNF and β-NGF in obese children, which were positively correlated with obesity measures, blood pressure, and insulin levels.
Review
Nutrition & Dietetics
Emily Knight, Thangiah Geetha, Donna Burnett, Jeganathan Ramesh Babu
Summary: While diet and dietary patterns play a significant role in reducing the risk of PD or alleviating PD severity, inconsistent results and the need for further evidence highlight the necessity for more research before making dietary recommendations. Studies on the potential beneficial effects of dietary patterns on PD should also consider potential risks.
Article
Genetics & Heredity
Priyadarshni Patel, Vaithinathan Selvaraju, Jeganathan Ramesh Babu, Xu Wang, Thangiah Geetha
Summary: Despite vigorous efforts by health experts, childhood obesity continues to affect the health of millions of children worldwide. Research has found that African American children are more likely than other racial and ethnic groups to have obesity-related risk factors, and DNA methylation may play a role in obesity-related genes with a race-specific link.
Review
Biochemistry & Molecular Biology
Adebowale Samuel Oyerinde, Vaithinathan Selvaraju, Jeganathan Ramesh Babu, Thangiah Geetha
Summary: Obesity is associated with various health issues, and abdominal fat is considered a serious risk factor for obesity-related diseases. The accumulation of visceral fat can promote the release of pro-oxidants, pro-inflammatory substances, and reactive oxygen species (ROS). Volatile organic compounds (VOCs) produced by the metabolic process in the human body can serve as biomarkers for obesity-related metabolic alterations and disease. This review focuses on the relationship between oxidative stress and VOCs in obesity.
Review
Pediatrics
Johanna Key, Donna Burnett, Jeganathan Ramesh Babu, Thangiah Geetha
Summary: This article examines the impact of food deserts on childhood obesity, and studies have found that the majority show no significant association between the food environment and increased BMI. Therefore, further research is needed to explore the effects of limited access to healthy foods in food deserts.
Review
Biochemistry & Molecular Biology
Erika Richter, Thangiah Geetha, Donna Burnett, Tom L. Broderick, Jeganathan Ramesh Babu
Summary: T2DM is a metabolic disorder characterized by hyperglycemia and glucose intolerance, while Alzheimer's disease is a neurodegenerative disorder with cognitive and behavioral loss. There is a link between the two diseases and certain bioactive compounds found in plants can potentially be used for prevention and treatment. However, more research is needed to establish their clinical efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Emily Knight, Thangiah Geetha, Tom L. L. Broderick, Jeganathan Ramesh Babu
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta plaques and neurofibrillary tau tangles. Oxidative stress is believed to play a role in AD's neurodegenerative process. This review examines the impact of antioxidant supplementation on cognitive function in individuals with AD, focusing on clinical trials conducted between 2012 and 2022. The results of these trials did not provide strong evidence for the beneficial role of antioxidant supplements on cognitive function in AD, but varied among different antioxidants and trials.
Article
Gastroenterology & Hepatology
Baskar Balakrishnan, Vaithinathan Selvaraju, Jun Chen, Priscilla Ayine, Lu Yang, Jeganathan Ramesh Babu, Thangiah Geetha, Veena Taneja
Summary: This study aimed to investigate the differences in gut and oral microbial communities in obese African American and European American children, indicating a specific association between ethnicity and microbial profiles.