The nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo

Structural insight into nucleosome transcription by RNA polymerase II with elongation factors

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The expanding landscape of ‘oncohistone’ mutations in human cancers

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Structural rearrangements of the histone octamer translocate DNA

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The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h

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Residues in the Nucleosome Acidic Patch Regulate Histone Occupancy and Are Important for FACT Binding in Saccharomyces cerevisiae

(2017) Amelia J. Hodges et al.   GENETICS

MNase-Sensitive Complexes in Yeast: Nucleosomes and Non-histone Barriers

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ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference

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Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler

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Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex

(2017) Youwei Xu et al.   Nature Communications

Residues in the Nucleosome Acidic Patch Regulate Histone Occupancy and Are Important for FACT Binding in Saccharomyces cerevisiae

(2017) Amelia J. Hodges et al.   GENETICS

Nucleosome repositioning underlies dynamic gene expression

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Integrated molecular mechanism directing nucleosome reorganization by human FACT

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The Modifier of Transcription 1 (Mot1) ATPase and Spt16 Histone Chaperone Co-regulate Transcription through Preinitiation Complex Assembly and Nucleosome Organization

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Noncoding Transcription Is a Driving Force for Nucleosome Instability inspt16Mutant Cells

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The Histone Modification Domain of Paf1 Complex Subunit Rtf1 Directly Stimulates H2B Ubiquitylation through an Interaction with Rad6

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Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown

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Structural mechanism for the recognition and ubiquitination of a single nucleosome residue by Rad6–Bre1

(2016) Laura D. Gallego et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial–mesenchymal transition

(2016) Siming Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for histone H2B deubiquitination by the SAGA DUB module

(2016) M. T. Morgan et al.   SCIENCE

Lateral Thinking: How Histone Modifications Regulate Gene Expression

(2016) Moyra Lawrence et al.   TRENDS IN GENETICS

The Chd1 chromatin remodeler shifts hexasomes unidirectionally

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In Vivo Mapping of FACT–Histone Interactions Identifies a Role of Pob3 C-terminus in H2A–H2B Binding

(2015) Christian Hoffmann et al.   ACS Chemical Biology

FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs

(2015) David J. Kemble et al.   MOLECULAR CELL

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

The Nucleosome Acidic Patch Regulates the H2B K123 Monoubiquitylation Cascade and Transcription Elongation in Saccharomyces cerevisiae

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Nucleosome Structure and Function

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Catalysis-dependent stabilization of Bre1 fine-tunes histone H2B ubiquitylation to regulate gene transcription

(2014) Glenn G. Wozniak et al.   GENES & DEVELOPMENT

Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging

(2014) Z. Hu et al.   GENES & DEVELOPMENT

Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate

(2014) Gilad Fuchs et al.   GENOME RESEARCH

H2B Ubiquitylation Promotes RNA Pol II Processivity via PAF1 and pTEFb

(2014) Lipeng Wu et al.   MOLECULAR CELL

Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation

(2014) Harihar Basnet et al.   NATURE

Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome

(2014) Robert K. McGinty et al.   NATURE

deepTools: a flexible platform for exploring deep-sequencing data

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A Cascade of Histone Modifications Induces Chromatin Condensation in Mitosis

(2014) Bryan J. Wilkins et al.   SCIENCE

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A

(2014) Francesca Mattiroli et al.   Nature Communications

Nucleosome Acidic Patch Promotes RNF168- and RING1B/BMI1-Dependent H2AX and H2A Ubiquitination and DNA Damage Signaling

(2014) Justin W. Leung et al.   PLoS Genetics

The role of the nucleosome acidic patch in modulating higher order chromatin structure

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The Recruitment of theSaccharomyces cerevisiaePaf1 Complex to Active Genes Requires a Domain of Rtf1 That Directly Interacts with the Spt4-Spt5 Complex

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Structural basis of histone H2A–H2B recognition by the essential chaperone FACT

(2013) Maria Hondele et al.   NATURE

Structural insights into Paf1 complex assembly and histone binding

(2013) Xinlei Chu et al.   NUCLEIC ACIDS RESEARCH

Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin

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Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex

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(2012) Ben Langmead et al.   NATURE METHODS

Histone H3R17me2a mark recruits human RNA Polymerase-Associated Factor 1 Complex to activate transcription

(2012) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small region of Rtf1 protein can substitute for complete Paf1 complex in facilitating global histone H2B ubiquitylation in yeast

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The role of FACT in making and breaking nucleosomes

(2011) Tim Formosa   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Global analysis of core histones reveals nucleosomal surfaces required for chromosome bi-orientation

(2011) Satoshi Kawashima et al.   EMBO JOURNAL

Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123

(2011) J. M. Schulze et al.   GENES & DEVELOPMENT

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(2011) K. Batta et al.   GENES & DEVELOPMENT

Identification of a Role for Histone H2B Ubiquitylation in Noncoding RNA 3′-End Formation Through Mutational Analysis of Rtf1 inSaccharomyces cerevisiae

(2011) Brett N. Tomson et al.   GENETICS

The Histone Chaperone FACT: Structural Insights and Mechanisms for Nucleosome Reorganization

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The RING Finger Protein MSL2 in the MOF Complex Is an E3 Ubiquitin Ligase for H2B K34 and Is Involved in Crosstalk with H3 K4 and K79 Methylation

(2011) Lipeng Wu et al.   MOLECULAR CELL

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(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction

(2011) Beat Fierz et al.   Nature Chemical Biology

The elongation rate of RNA polymerase determines the fate of transcribed nucleosomes

(2011) Lacramioara Bintu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Packing Mechanism for Nucleosome Organization Reconstituted Across a Eukaryotic Genome

(2011) Z. Zhang et al.   SCIENCE

The Sequence Alignment/Map format and SAMtools

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RAD6-Mediated Transcription-Coupled H2B Ubiquitylation Directly Stimulates H3K4 Methylation in Human Cells

(2009) Jaehoon Kim et al.   CELL

yFACT Induces Global Accessibility of Nucleosomal DNA without H2A-H2B Displacement

(2009) Hua Xin et al.   MOLECULAR CELL

Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability

(2009) M. B. Chandrasekharan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells

(2008) Neri Minsky et al.   NATURE CELL BIOLOGY

A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation

(2008) Shima Nakanishi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The FACT Spt16 “peptidase” domain is a histone H3–H4 binding module

(2008) Tobias Stuwe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA