Understanding the role of the cytoprotective transcription factor nuclear factor erythroid 2–related factor 2—lessons from evolution, the animal kingdom and rare progeroid syndromes

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

(2019) Rajbir Singh et al.   Nature Communications

The angiotensin-(1-7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation

(2019) Alejandra Romero et al.   AGING CELL

Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging

(2019) Georges E. Janssens et al.   Cell Reports

Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

(2018) Emiliano Zamponi et al.   AGING CELL

Bardoxolone Methyl Improves Kidney Function in Patients with Chronic Kidney Disease Stage 4 and Type 2 Diabetes: Post-Hoc Analyses from Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes Study

(2018) Melanie P. Chin et al.   AMERICAN JOURNAL OF NEPHROLOGY

Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo

(2018) Yue Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Apigenin prevents metabolic syndrome in high-fructose diet-fed mice by Keap1-Nrf2 pathway

(2018) Min Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Targeting of stress response pathways in the prevention and treatment of cancer

(2018) Jaroslav Zelenka et al.   BIOTECHNOLOGY ADVANCES

Dietary inflammatory index and all-cause mortality in large cohorts: The SUN and PREDIMED studies

(2018) Ana Garcia-Arellano et al.   CLINICAL NUTRITION

Physical Exercise Reduces Cytotoxicity and Up-Regulates Nrf2 and UPR Expression in Circulating Cells of Peripheral Artery Disease Patients: An Hypoxic Adaptation?

(2018) Anna Maria Fratta Pasini et al.   Journal of Atherosclerosis and Thrombosis

Investigating Nrf2-associated non-coding RNAs in the hibernating ground squirrel, Ictidomys tridecemlineatus

(2018) Jacques J. Frigault et al.   JOURNAL OF THERMAL BIOLOGY

Youthful systemic milieu alleviates renal ischemia-reperfusion injury in elderly mice

(2018) Dong Liu et al.   KIDNEY INTERNATIONAL

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom

(2018) Peter Stenvinkel et al.   Nature Reviews Nephrology

Rethinking progression of CKD as a process of punctuated equilibrium

(2018) Richard J. Johnson et al.   Nature Reviews Nephrology

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Comprehensive renoprotective effects of ipragliflozin on early diabetic nephropathy in mice

(2018) Michitsugu Kamezaki et al.   Scientific Reports

Living High and Feeling Low

(2018) Brent M. Kious et al.   HARVARD REVIEW OF PSYCHIATRY

Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age

(2018) J Graham Ruby et al.   eLife

Editorial: Hypoxia in Kidney Disease

(2018) Fredrik Palm et al.   Frontiers in Physiology

MicroRNAs mediate the senescence-associated decline of NRF2 in endothelial cells

(2018) Suvi M. Kuosmanen et al.   Redox Biology

Modulating NRF2 in Disease: Timing Is Everything

(2018) Matthew Dodson et al.   Annual Review of Pharmacology and Toxicology

Aging, Cell Senescence, and Chronic Disease

(2018) Tamara Tchkonia et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation

(2018) Gabor A. Fulop et al.   GeroScience

Keap1–Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress

(2017) Ji-chun Zhang et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Design, synthesis, and evaluation of curcumin derivatives as Nrf2 activators and cytoprotectors against oxidative death

(2017) Zhi-Shan Tu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Activation of the Nrf2-ARE Signaling Pathway Prevents Hyperphosphatemia-Induced Vascular Calcification by Inducing Autophagy in Renal Vascular Smooth Muscle Cells

(2017) Li Yao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dietary Protein Sources and Risk for Incident Chronic Kidney Disease: Results From the Atherosclerosis Risk in Communities (ARIC) Study

(2017) Bernhard Haring et al.   JOURNAL OF RENAL NUTRITION

Nonpharmacologic Strategies to Modulate Nuclear Factor Erythroid 2–related Factor 2 Pathway in Chronic Kidney Disease

(2017) Marta Esgalhado et al.   JOURNAL OF RENAL NUTRITION

Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time

(2017) Yuji Fuse et al.   MOLECULES

NRF2 as an Emerging Therapeutic Target

(2017) Ian M. Copple et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial function in hypoxic ischemic injury and influence of aging

(2017) P. Benson Ham et al.   PROGRESS IN NEUROBIOLOGY

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat

(2017) Thomas J. Park et al.   SCIENCE

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

(2017) Annika S. Axelsson et al.   Science Translational Medicine

Kimchi methanol extracts attenuate hepatic steatosis induced by high cholesterol diet in low-density lipoprotein receptor knockout mice through inhibition of endoplasmic reticulum stress

(2017) Minji Woo et al.   Journal of Functional Foods

Polyphenols associated with dietary fibers in plant foods: molecular interactions and bioaccessibility

(2017) Gustavo A González-Aguilar et al.   Current Opinion in Food Science

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

(2016) Ajaikumar B Kunnumakkara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Red meat and colorectal cancer: Nrf2-dependent antioxidant response contributes to the resistance of preneoplastic colon cells to fecal water of hemoglobin- and beef-fed rats

(2016) Reggie Surya et al.   CARCINOGENESIS

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

The anti-ageing hormone klotho induces Nrf2-mediated antioxidant defences in human aortic smooth muscle cells

(2016) Giuseppe Maltese et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Chronic Inflammation: Accelerator of Biological Aging

(2016) Bertrand Fougère et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases

(2016) Carla Regina et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Protective Effects of Hydrogen Sulfide in the Ageing Kidney

(2016) Cui-Lan Hou et al.   Oxidative Medicine and Cellular Longevity

H 2 S-induced thiol-based redox switches: Biochemistry and functional relevance for inflammatory diseases

(2016) Sebastian Longen et al.   PHARMACOLOGICAL RESEARCH

Antioxidant Defenses in the Brains of Bats during Hibernation

(2016) Qiuyuan Yin et al.   PLoS One

Activation of the Nrf2 Cell Defense Pathway by Ancient Foods: Disease Prevention by Important Molecules and Microbes Lost from the Modern Western Diet

(2016) Donald R. Senger et al.   PLoS One

Rising levels of atmospheric oxygen and evolution of Nrf2

(2016) Ranko Gacesa et al.   Scientific Reports

Age-related cellular changes in the long-lived bivalve A. islandica

(2015) Heike Gruber et al.   AGE

A novel mechanism for cytoprotection against hypoxic injury: δ-opioid receptor-mediated increase in Nrf2 translocation

(2015) Shan Cao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis

(2015) Ciric To et al.   CARCINOGENESIS

Vasculoprotective Effects of Dietary Cocoa Flavanols in Patients on Hemodialysis: A Double-Blind, Randomized, Placebo-Controlled Trial

(2015) T. Rassaf et al.   Clinical Journal of the American Society of Nephrology

Dose-dependent deleterious and salutary actions of the Nrf2 inducer dh404 in chronic kidney disease

(2015) Nosratola D. Vaziri et al.   FREE RADICAL BIOLOGY AND MEDICINE

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

(2015) T. Keith Blackwell et al.   FREE RADICAL BIOLOGY AND MEDICINE

T Lymphocyte-Specific Activation of Nrf2 Protects from AKI

(2015) S. Noel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanisms Contributing to Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated with Bardoxolone Methyl

(2014) Melanie P. Chin et al.   AMERICAN JOURNAL OF NEPHROLOGY

Integrative Biology Identifies Shared Transcriptional Networks in CKD

(2014) S. Martini et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Healthy aging diets other than the Mediterranean: A focus on the Okinawan diet

(2014) Donald Craig Willcox et al.   MECHANISMS OF AGEING AND DEVELOPMENT

High Amylose Resistant Starch Diet Ameliorates Oxidative Stress, Inflammation, and Progression of Chronic Kidney Disease

(2014) Nosratola D. Vaziri et al.   PLoS One

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

(2014) Ian M. Copple et al.   TOXICOLOGICAL SCIENCES

Activation of Nrf2 by dimethyl fumarate improves vascular calcification

(2014) Chae-Myeong Ha et al.   VASCULAR PHARMACOLOGY

Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction

(2013) Ines Sanchez-Roman et al.   EXPERIMENTAL GERONTOLOGY

Nrf2 activation: A potential strategy for the prevention of acute mountain sickness

(2013) Christina Lisk et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prolonged fasting activates Nrf2 in post-weaned elephant seals

(2013) J. P. Vazquez-Medina et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

A Heart That Beats for 500 Years: Age-Related Changes in Cardiac Proteasome Activity, Oxidative Protein Damage and Expression of Heat Shock Proteins, Inflammatory Factors, and Mitochondrial Complexes in Arctica islandica, the Longest-Living Noncolonial Animal

(2013) D. Sosnowska et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Role of Nrf2 in protection against acute kidney injury

(2013) Luke M. Shelton et al.   KIDNEY INTERNATIONAL

The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia–reperfusion injury in mice

(2013) Manchang Liu et al.   KIDNEY INTERNATIONAL

Inhibition of nuclear factor-erythroid 2–related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence

(2013) Daniela Volonte et al.   MOLECULAR BIOLOGY OF THE CELL

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB

(2013) Dilinaer Bolati et al.   BMC Nephrology

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

(2013) K. M. Holmstrom et al.   Biology Open

Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species

(2013) Rajitha T Kolamunne et al.   Redox Biology

The Naked Mole-Rat Response to Oxidative Stress: Just Deal with It

(2012) Kaitlyn N. Lewis et al.   ANTIOXIDANTS & REDOX SIGNALING

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

Extending healthy ageing: nutrient sensitive pathway and centenarian population

(2012) Sergio Davinelli et al.   Immunity & Ageing

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

(2011) Pablo E. Pergola et al.   NEW ENGLAND JOURNAL OF MEDICINE

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Nrf2 Expression Is Regulated by Epigenetic Mechanisms in Prostate Cancer of TRAMP Mice

(2010) Siwang Yu et al.   PLoS One

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

(2010) Brian Onken et al.   PLoS One

The rise of antioxidant signaling—The evolution and hormetic actions of Nrf2

(2010) Jonathan Maher et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice

(2009) Melinda S. Yates et al.   CARCINOGENESIS

Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice

(2009) Weisong Duan et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Cigarette Smoking Blocks the Protective Expression of Nrf2/ARE Pathway in Peripheral Mononuclear Cells of Young Heavy Smokers Favouring Inflammation

(2009) Ulisse Garbin et al.   PLoS One

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

(2009) V. I. Perez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA