Article
Gastroenterology & Hepatology
Liuyi Hao, Wei Zhong, Haibo Dong, Wei Guo, Xinguo Sun, Wenliang Zhang, Ruichao Yue, Tianjiao Li, Alexandra Griffiths, Ali Reza Ahmadi, Zhaoli Sun, Zhenyuan Song, Zhanxiang Zhou
Summary: The study reveals that hepatic ATF4 plays a pathological role in alcohol-induced mitochondrial dysfunction and liver injury by disrupting the NRF1-TFAM pathway. In patients with alcoholic liver disease, the activation of ATF4 is associated with mitochondrial dysfunction. Knocking out ATF4 or overexpressing TFAM can alleviate alcohol-induced liver damage. This is achieved through the negative regulation of TFAM expression by ATF4, affecting ethanol-mediated mitochondrial dysfunction and cell death.
Article
Agriculture, Multidisciplinary
Bei Yan, Lei Chen, Yanhui Wang, Jiacheng Zhang, Hui Zhao, Qinglian Hua, Shengjie Pei, Zihang Yue, Hui Liang, Huaqi Zhang
Summary: This study investigated the protective effect of apple polyphenol extract (APE) on hepatic steatosis, and found that APE supplementation reduced weight gain, liver index, and lipid levels, while alleviating histopathological changes. The study also revealed that APE improved hepatic steatosis by inhibiting endoplasmic reticulum stress-related signaling pathways.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Erdi Sozen, Tugce Demirel-Yalciner, Dyana Sari, Nesrin Kartal Ozer
Summary: Non-alcoholic fatty liver disease (NAFLD) is a major global health issue associated with obesity. This study reveals that cholesterol can induce ER stress and increase the expression of CHOP. Cholesterol accumulation in hepatocytes activates the IRE1/p38 pathway, leading to the development of NASH. Supplementation of alpha-tocopherol can inhibit the activation of IRE1/p38/CHOP and prevent NASH development.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Nutrition & Dietetics
Hung-Tsung Wu, Ching-Han Lin, Hsiu-Ling Pai, Yi-Cheng Chen, Kai-Pi Cheng, Hsin-Yu Kuo, Chung-Hao Li, Horng-Yih Ou
Summary: This study found that supplementation of sucralose enhances high-fat-diet induced hepatic steatosis and induces reactive oxygen species (ROS) generation and endoplasmic reticulum (ER) stress in HepG2 cells. Pretreating with ROS or ER stress inhibitors reverses the effects of sucralose on lipogenesis. Furthermore, pretreating with taste receptor type 1 membrane 3 (T1R3) inhibitor or T1R3 knockdown can reverse sucralose-induced lipogenesis in HepG2 cells.
FRONTIERS IN NUTRITION
(2022)
Article
Immunology
Shixia Zhang, Jilang Tang, Chen Sun, Nuannuan Zhang, Xiaqing Ning, Xueqin Li, Jiaqi Wang
Summary: Dexmedetomidine (DEX) protects the liver against ischemia-reperfusion injury (IRI) by reducing oxidative stress, endoplasmic reticulum stress (ERS), and apoptosis. DEX increases antioxidant activity and reduces oxidative damage in BRL-3A cells. It also inhibits MAPK signaling pathway activation and ERS to prevent cell apoptosis. Animal studies confirm that DEX alleviates histopathological injury and improves liver function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Guangmang Liu, Jingyuan Tao, Jiajia Lu, Gang Jia, Hua Zhao, Xiaoling Chen, Gang Tian, Jingyi Cai, Ruinan Zhang, Jing Wang
Summary: Tryptophan supplementation can improve gut health in piglets by enhancing antioxidant status, alleviating inflammation, and regulating various cellular processes.
Article
Biochemistry & Molecular Biology
Yang Yang, Yuan Qu, Xiaoqiang Lv, Ruijin Zhao, Jing Yu, Suying Hu, Jingqi Kang, Yaling Zhang, Ye Gong, Tingting Cui, Xin Zhang, Yaping Yan
Summary: The study found that sesamol has a protective effect against NASH and atherosclerosis induced by HF-HCC diet in rats, reducing liver and adipose tissue damage, improving metabolism disorders and vascular endothelial function. Sesamol also inhibited hepatic NLRP3 expression and ERS-IRE1 signaling pathway activation, further demonstrating its potential as a dietary supplement for preventing these diseases.
Article
Cell Biology
Haiying Liu, Linyu Dai, Ming Wang, Fumin Feng, Yonghong Xiao
Summary: This study demonstrated that tunicamycin can induce the apoptosis of HSCs by increasing intracellular Ca2+ concentration and enhancing the expression of ERS proteins, while decreasing the expression of antiapoptotic proteins. The findings suggest that tunicamycin induces HSC apoptosis through the calpain-2/Ca2+-dependent ERS pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Food Science & Technology
Omayma A. R. Abo-Zaid, Fatma S. M. Moawed, Effat Soliman Ismail, Esraa S. A. Ahmed
Summary: This study aimed to investigate the suppressive effect of beta-sitosterol on liver injury and ER stress-induced apoptosis. The results showed that beta-sitosterol reduced liver damage markers, oxidative stress, and inflammatory mediators, while improving lipid metabolism. Furthermore, it inhibited ER stress and apoptosis, thereby alleviating hepatic injury.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Gastroenterology & Hepatology
Fan Xiao, Meixin Gao, Junru Yang, Lingling He, Hongshan Wei
Summary: Our study revealed that FAM172A may alleviate NAFLD by inhibiting ER stress. Loss of FAM172A led to increased expression of ATF6, peIF2 alpha, and decreased expression of IRE1 alpha. Moreover, FAM172A was shown to interact directly with ATF6, peIF2 alpha, and IRE1 alpha in the ER.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Alyssa Kriegermeier, Angela Hyon, Meredith Sommars, Susan Hubchak, Brian LeCuyer, Xiaoying Liu, Grant Barish, Richard M. Green
Summary: The study revealed that weanling mice exhibit attenuated hepatic XBP1 signaling and impaired UPR activation, leading to increased susceptibility to bile acid-induced hepatic injury compared to adult mice.
Article
Pharmacology & Pharmacy
Dan Zhang, Shanzhuang Niu, Yicheng Ma, Hang Chen, Yu Wen, Mingke Li, Bo Zhou, Yi Deng, Chunjing Shi, Guangyu Pu, Meng Yang, Xianmei Wang, Chenggang Zou, Yuanli Chen, Lanqing Ma
Summary: This study found that fenofibrate can alleviate ER stress and improve the pathology of NAFLD by regulating the expression of let-7 miRNA and SERCA2b. This provides new insights into the specific mechanism of fenofibrate in treating NAFLD and improving lipid metabolism disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ne N. Wu, Lifeng Wang, Lu Wang, Xihui Xu, Gary D. Lopaschuk, Yingmei Zhang, Jun Ren
Summary: Researchers in China have discovered that an enzyme called Parkin can restrict the release of DNA from mitochondria, thereby preventing liver fibrosis. Enhancing the protective ability of Parkin could lead to new therapeutic approaches for liver disease.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Environmental Sciences
Jicang Wang, Lulu Ding, Ke Wang, Ruxue Huang, Wenjing Yu, Bingzhao Yan, Hongwei Wang, Cai Zhang, Zijun Yang, Zongping Liu
Summary: This study aimed to determine the protective effect of quercetin (Que) on cadmium (Cd)-induced hepatotoxicity. Through in vivo and in vitro experiments using rat models, the researchers found that Cd caused liver injury and cell apoptosis, and activated endoplasmic reticulum stress (ERS) signaling pathways. However, Que was able to improve hepatocyte vitality, reduce liver damage and oxidative stress caused by Cd.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Yiqi Wang, Lian Duan, Xing Zhang, Yang Jiao, Ying Liu, Lingling Dai, Hong Yan
Summary: The study demonstrated that chronic exposure to ACR can impair motor skills, muscle strength, and coordination in rats, as well as damage the morphology of the cerebellum, leading to increased apoptosis and initiation of autophagy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)