Article
Fisheries
Chi Wang, Cheng Zhang, Haibo Yu, Ziye Zan, Jialin Li, Pengju Li, Xiaotian Zhang, Hong Ji, Qinfeng Gao
Summary: In this study, the effects of glycerol monolaurate (GML) and triglycerol monolaurate (TGML) on excessive lipid accumulation and liver damage caused by a high-fat diet (HFD) were explored in zebrafish. The results showed that GML and TGML reduced lipid synthesis, improved lipid decomposition, and alleviated liver oxidative stress and inflammation caused by HFD by regulating AMPK.
Article
Nutrition & Dietetics
Qianqian Xu, Jiangcheng Ye, Mingxiu Gong, Yifan Zhang, Yiwei Yuan, Jin Zhao
Summary: This study aimed to investigate the effects of theabrownin from Wuniuzao dark tea on hepatic lipid metabolism and gut microbiota in mice fed a high-fat diet. The results showed that theabrownin reduced body weight and epididymis fat weight in obese mice and decreased serum triglycerides, cholesterol, and liver enzyme activities. In addition, theabrownin downregulated gene expression related to fatty acid synthesis and lipid production and improved gut microbiota composition.
Article
Agriculture, Multidisciplinary
Xinbo Zhou, Junjie Zhang, Yutong Sun, Jian Shen, Bo Sun, Qingquan Ma
Summary: This study found that glutamine (Gln) has a positive effect on liver steatosis and promotes hepatic homeostasis by improving glucose metabolism and regulating signaling pathways. Obese mice fed with Gln had higher levels of colonic short-chain fatty acids (SCFAs) and lower levels of inflammation factor proteins, and a decrease in the abundance of Firmicutes bacteria was observed.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Xiaoxian Xie, Mengya Zhang, Lei Sun, Ting Wang, Zhengyan Zhu, Ruonan Shu, Fengchun Wu, Zezhi Li
Summary: This study demonstrates that crocin-I may inhibit obesity by reducing body weight, improving glucose resistance, and alleviating intestinal microbial disorders in HFD-induced obese mice. Crocin-I also helps in restoring SCFAs levels and repairing altered intestinal barrier functioning and inflammation in HFD-induced obese mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Mengyu Wang, Hui Han, Fan Wan, Ruqing Zhong, Yoon Jung Do, Sang-Ik Oh, Xuemeng Lu, Lei Liu, Bao Yi, Hongfu Zhang
Summary: This study found that DHQ improved lipid dysmetabolism in the body, especially in the liver, and was associated with altered gut flora.
Article
Pharmacology & Pharmacy
Shiyue Luo, Lixiao Zhou, Xuejun Jiang, Yinyin Xia, Lishuang Huang, Run Ling, Shixin Tang, Zhen Zou, Chengzhi Chen, Jingfu Qiu
Summary: Asparagus cochinchinensis, a traditional Chinese medicine, has shown anti-inflammatory properties and the ability to regulate gut microbiota. In a study on obese mice, it was found that the aqueous extract from Asparagus cochinchinensis root (ACE) reduced weight gain and relieved dyslipidemia induced by a high-fat diet. ACE treatment also improved glucose tolerance and insulin resistance, reduced inflammation and lipogenesis in the liver and adipose tissues, and reshaped the gut microbiota of obese mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Chongyan Zhao, Qingsong Qu, Fang Yang, Zhixun Li, Pengshuo Yang, Lu Han, Xinyuan Shi
Summary: The study found that fermented Panax ginseng by Monascus ruber could alleviate obesity features in rats, decrease serum total cholesterol, LDL cholesterol and IgA levels, increase bile acid excretion in feces, regulate lipid accumulation in hepatocytes, and enhance gut microbiota diversity and abundance.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Yongshou Yang, Rikako Fukui, Huijuan Jia, Hisanori Kato
Summary: The study revealed that dietary supplementation with amaranth significantly reduced triglycerides, total cholesterol, and phospholipids levels in the liver, as well as downregulated the expression of lipogenesis-related genes. Amaranth supplementation also reversed the reduction in gut microbiota diversity and richness induced by a high-fat diet.
Article
Food Science & Technology
Junhui Zhang, Ji'an Wei, Tao Liu, Jun Tang, Xi Zhang, Fengqin Feng, Haiying Cai, Minjie Zhao
Summary: Recent research suggests that the potential health risks of food additives on gut microbiota should be carefully considered. The widely used food preservative and emulsifier, glycerol monocaprylate (GMC), was found to significantly improve visceral fat accumulation and systemic inflammation in mice fed a high-fat diet. Additionally, GMC improved the composition and function of gut microbiota, leading to an increase in beneficial bacteria and the production of short chain fatty acids. Overall, the study revealed the potential of GMC to attenuate metabolic disorders and gut microbiota dysbiosis, emphasizing the importance of evaluating food additives based on their specific characteristics.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Lin Feng, Jie Zhou, Liang Zhang, Panpan Liu, Pengcheng Zheng, Shiwei Gao, Chuankui Song, Yongchao Yu, Ziming Gong, Xiaochun Wan
Summary: The study found that QZT extract can significantly prevent weight gain and fat accumulation, while also reducing serum levels of total cholesterol and triglycerides. This is accompanied by changes in the Firmicutes-to-Bacteroidetes ratio and the relative abundance of S24-7 and Ruminococcaceae in the gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Hui Han, Mengyu Wang, Ruqing Zhong, Bao Yi, Martine Schroyen, Hongfu Zhang
Summary: This study investigates the mechanism through which the gut microbiota influences hepatic lipid metabolism in high-fat diet-fed mice. Gut microbiota depletion was found to reduce body weight, fat deposition, glucose levels, cholesterol levels, insulin levels, and leptin levels in these mice. Additionally, it inhibited excessive hepatic lipid accumulation and changed the expression of genes involved in cholesterol and fatty acid metabolism. The abundance of bacteria associated with abnormal metabolism and inflammation was also reduced. There was a strong correlation between the altered gut microbiota abundance and the serum cholesterol level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Elaine Soares, Aruanna C. Soares, Patricia Leticia Trindade, Elisa B. Monteiro, Fabiane F. Martins, Andrew J. Forgie, Kim O. P. Inada, Graziele F. de Bem, Angela Resende, Daniel Perrone, Vanessa Souza-Mello, Francisco Tomas-Barberan, Benjamin P. Willing, Mariana Monteiro, Julio B. Daleprane
Summary: The study showed that polyphenol-rich jaboticaba peel and seed powder improved non-alcoholic fatty liver disease induced by a high-fat diet, through ameliorating gut microbial community structure and reducing symptoms of metabolic syndrome.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Ju Kyoung Oh, Robie Vasquez, Sang Hoon Kim, Je Hyeon Lee, Eun Joo Kim, Soon-Kwang Hong, Dae-Kyung Kang
Summary: The study showed that supplementation of neoagarooligosaccharides (NAOs) in obese rats can reduce body weight, improve metabolism, and modulate the gut microbiome by enriching bacteria negatively associated with obesity. This suggests that the anti-obesity effect of NAOs may be linked to their regulatory effect on gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Wei Guo, Suqin Zhu, Shiyang Li, Yinong Feng, Haohao Wu, Mingyong Zeng
Summary: This study evaluated the anti-obesity effects of two microalgae polysaccharides in obese mice induced by a high-fat diet. The polysaccharides were found to effectively improve obesity-related issues by modulating gut microbiome-mediated host lipid metabolism.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Ang Li, Jin Wang, Yuanyifei Wang, Bowei Zhang, Zhenjia Chen, Junling Zhu, Xiaowen Wang, Shuo Wang
Summary: Jinqiao II tartary buckwheat has the potential to alleviate lipid metabolism disorders by reducing hyperlipidemia, fat accumulation, and liver damage, as well as modulating gut microbiota diversity and structure.
Article
Biotechnology & Applied Microbiology
H. Cai, T. Zhang, M. Zhao, J. Mao, C. Cai, F. Feng
LETTERS IN APPLIED MICROBIOLOGY
(2017)
Article
Agriculture, Multidisciplinary
Minjie Zhao, Haiying Cai, Mengyun Liu, Lingli Deng, Yang Li, Hui Zhang, Fengqin Feng
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2019)
Article
Chemistry, Multidisciplinary
Haiyang Cui, Hao Cao, Haiying Cai, Karl-Erich Jaeger, Mehdi D. Davari, Ulrich Schwaneberg
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Food Science & Technology
Haiying Cai, Qi Zhang, Lingzhi Shen, Jie Luo, Ruiyu Zhu, Jianwei Mao, Minjie Zhao, Chenggang Cai
LWT-FOOD SCIENCE AND TECHNOLOGY
(2019)
Article
Microbiology
Minjie Zhao, Zengliang Jiang, Haiying Cai, Yang Li, Qiufen Mo, Lingli Deng, Hao Zhong, Tao Liu, Hui Zhang, Jing X. Kang, Fengqin Feng
Article
Food Science & Technology
Hao Zhong, Abdullah, Yipeng Zhang, Minjie Zhao, Junhui Zhang, Hui Zhang, Yuhang Xi, Haiying Cai, Fengqin Feng
Summary: This study aimed to explore novel antidiabetic strains from Lactobacillus plantarum and evaluated their potential through in vitro and in vivo models. Lactobacillus plantarum strain YJ7 showed high adhesion rates and antioxidant abilities, while strain N1 exhibited good inhibitory activity against α-glucosidase. In vivo studies demonstrated that YJ7 supplementation prevented insulin resistance and inflammation in high-fat diet fed mice.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Haiying Cai, Trish Dumba, Yuhua Sheng, Jing Li, Qingfeng Lu, Chang Liu, Chenggang Cai, Fengqin Feng, Minjie Zhao
Summary: This study found that many symbiont fungi of soybean were present in sufu samples, while lactic acid bacteria were abundant in all samples. According to the principal coordinate analysis and hierarchical clustering analysis, the bacterial communities of sufu samples could generally be clustered into the LAB clade and Bacillus clade. Furthermore, dressing flavor of sufu samples during post-fermentation was not a major factor in shaping microbial communities.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Microbiology
Qiufen Mo, Tao Liu, Aikun Fu, Shengyue Ruan, Hao Zhong, Jun Tang, Minjie Zhao, Yang Li, Songming Zhu, Haiying Cai, Fengqin Feng
Summary: Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory gastrointestinal condition that cannot be completely cured due to its complex pathogenesis. Glycerol monolaurate (GML) has been found to have antimicrobial, anti-inflammatory, and immunoregulatory properties. Research on mice showed that GML pretreatment was more effective in reducing weight loss, disease activity index, colonic inflammation, and proinflammatory responses compared to cotreatment. Furthermore, the increase in beneficial gut bacteria and fecal short-chain fatty acids after GML pretreatment contributed to faster and significant remission of colitis.
Article
Food Science & Technology
Minjie Zhao, Junhui Zhang, Tao Liu, Jing Wang, Haiying Cai, Xi Zhang, Doris Quay Huai Xia, Fengqin Feng, Jun Tang
Summary: This study evaluated the regulation of lauric acid (LA), glycerol monolaurate (GML), and lauric triglyceride (GTL) on metabolic health and gut microbiota in high fat diet-fed mice. The results showed that LA and its glycerides improved hyperlipidemia, while GML had a more pronounced effect on glucose metabolism and inflammation. Additionally, LA and its glycerides modulated gut microbiota with increased Bifidobacterium and decreased Desulfovibrio, which were closely related to metabolic improvements.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Food Science & Technology
Qianqian Wang, Fei Shen, Junhui Zhang, Haiying Cai, Ya Pan, Tengjia Sun, Yihang Gong, Juan Du, Hao Zhong, Fengqin Feng
Summary: This study shows that wheat peptides (WP) can alleviate constipation symptoms in humans and mice. The mechanisms behind this effect may involve improving water-electrolyte metabolism, promoting intestinal motility, and reshaping gut microbiota.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Food Science & Technology
Chenggang Cai, Miaomiao Zhao, Feng Yao, Ruiyu Zhu, Haiying Cai, Suqin Shao, Xiu-Zhen Li, Ting Zhou
Summary: This study investigates the interactions between DON and natural microbial flora, and finds that microbial consortia can effectively degrade DON, with DON affecting the diversity of bacterial flora.
Article
Biochemistry & Molecular Biology
Junhui Zhang, Huilin Yu, Qianqian Wang, Haiying Cai, Fei Shen, Shengyue Ruan, Yue Wu, Tao Liu, Fengqin Feng, Minjie Zhao
Summary: This study found that octyl and decyl glycerate (ODG), a medium-chain triglyceride (MCT), can alter the composition of the gut microbiota and have an impact on glucose and lipid metabolism and inflammation. The effects of ODG on lipid metabolism differ under different dietary patterns. Moreover, ODG supplementation also leads to changes in the gut microbiota, which may contribute to the alterations in metabolism and inflammation and may be influenced by dietary patterns.
Article
Food Science & Technology
Junhui Zhang, Ji'an Wei, Tao Liu, Jun Tang, Xi Zhang, Fengqin Feng, Haiying Cai, Minjie Zhao
Summary: Recent research suggests that the potential health risks of food additives on gut microbiota should be carefully considered. The widely used food preservative and emulsifier, glycerol monocaprylate (GMC), was found to significantly improve visceral fat accumulation and systemic inflammation in mice fed a high-fat diet. Additionally, GMC improved the composition and function of gut microbiota, leading to an increase in beneficial bacteria and the production of short chain fatty acids. Overall, the study revealed the potential of GMC to attenuate metabolic disorders and gut microbiota dysbiosis, emphasizing the importance of evaluating food additives based on their specific characteristics.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Junhui Zhang, Huilin Yu, Hao Zhong, Qianqian Wang, Jun Tang, Fei Shen, Haiying Cai, Tao Liu, Fengqin Feng, Minjie Zhao
Summary: Glycerol monodecanoate (GMD) is a medium-chain monoacylglycerol with emulsifying and antibacterial properties. This study found that different doses of GMD had inconsistent effects on lipid metabolism by differentially altering the gut microbiota composition. However, all doses of GMD showed excellent effects on increasing insulin sensitivity and improving inflammation.