Potential drugs used in the antibody-drug conjugate (ADC) architecture for cancer therapy
出版年份 2019 全文链接
标题
Potential drugs used in the antibody-drug conjugate (ADC) architecture for cancer therapy
作者
关键词
-
出版物
JOURNAL OF CELLULAR PHYSIOLOGY
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2019-06-19
DOI
10.1002/jcp.28967
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton
- (2018) Michel O. Steinmetz et al. TRENDS IN CELL BIOLOGY
- A developed antibody–drug conjugate rituximab-vcMMAE shows a potent cytotoxic activity against CD20-positive cell line
- (2018) Meghdad Abdollahpour-Alitappeh et al. Artificial Cells Nanomedicine and Biotechnology
- Uncialamycin as a novel payload for antibody drug conjugate (ADC) based targeted cancer therapy
- (2018) Naidu S. Chowdari et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Antibody-drug conjugates (ADCs) for cancer therapy: Strategies, challenges, and successes
- (2018) Meghdad Abdollahpour-Alitappeh et al. JOURNAL OF CELLULAR PHYSIOLOGY
- DS-8201a, a new HER2-targeting antibody-drug conjugate incorporating a novel DNA topoisomerase I inhibitor, overcomes HER2-positive gastric cancer T-DM1 resistance
- (2017) Naoki Takegawa et al. INTERNATIONAL JOURNAL OF CANCER
- Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy
- (2017) Hao Chen et al. MOLECULES
- Strategies and challenges for the next generation of antibody–drug conjugates
- (2017) Alain Beck et al. NATURE REVIEWS DRUG DISCOVERY
- From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs)
- (2016) Julia Mantaj et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads
- (2016) Takashi Nakada et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity
- (2016) Edward J. Hennessy BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Antibody drug conjugates
- (2016) Ray Bakhtiar BIOTECHNOLOGY LETTERS
- Antibody-drug conjugates—an emerging class of cancer treatment
- (2016) Nikolaos Diamantis et al. BRITISH JOURNAL OF CANCER
- A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy
- (2016) John Y. Li et al. CANCER CELL
- DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1
- (2016) Y. Ogitani et al. CLINICAL CANCER RESEARCH
- Linkers Having a Crucial Role in Antibody–Drug Conjugates
- (2016) Jun Lu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Antibody-drug conjugates: Current status and future perspectives
- (2016) Rémy Gébleux et al. PHARMACOLOGY & THERAPEUTICS
- Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments
- (2016) Julia Mantaj et al. PLoS One
- Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing
- (2015) Wayne C. Widdison et al. BIOCONJUGATE CHEMISTRY
- Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapeutics
- (2015) Eunhee G. Kim et al. Biomolecules & Therapeutics
- Antibody-drug conjugates as novel anti-cancer chemotherapeutics
- (2015) C. Peters et al. BIOSCIENCE REPORTS
- A Novel Anti-CD22 Anthracycline-Based Antibody-Drug Conjugate (ADC) That Overcomes Resistance to Auristatin-Based ADCs
- (2015) S.-F. Yu et al. CLINICAL CANCER RESEARCH
- First-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 Conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid Tumors
- (2015) A. N. Starodub et al. CLINICAL CANCER RESEARCH
- Antibody-targeted drugs and drug resistance—Challenges and solutions
- (2015) LeeRon Shefet-Carasso et al. DRUG RESISTANCE UPDATES
- Anti-Endosialin Antibody-Drug Conjugate: Potential in Sarcoma and Other Malignancies
- (2015) C. Rouleau et al. MOLECULAR CANCER THERAPEUTICS
- Preclinical and clinical development of inotuzumab-ozogamicin in hematological malignancies
- (2015) Boris Shor et al. MOLECULAR IMMUNOLOGY
- Antibody–Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs
- (2015) Christopher R. Behrens et al. MOLECULAR PHARMACEUTICS
- Chemistry and biology of tubulysins: antimitotic tetrapeptides with activity against drug resistant cancers
- (2015) Bryan C. Murray et al. NATURAL PRODUCT REPORTS
- Systems biology approaches to adverse drug effects: the example of cardio-oncology
- (2015) Sherry-Ann Brown et al. Nature Reviews Clinical Oncology
- Computational Studies Support the Role of the C7-Sibirosamine Sugar of the Pyrrolobenzodiazepine (PBD) Sibiromycin in Transcription Factor Inhibition
- (2014) Paul J. M. Jackson et al. ACS Chemical Biology
- Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy
- (2014) Ravi V. J. Chari et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Antibody–drug conjugates—A new wave of cancer drugs
- (2014) Hervé Bouchard et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Development of Novel ADCs: Conjugation of Tubulysin Analogues to Trastuzumab Monitored by Dual Radiolabeling
- (2014) R. Cohen et al. CANCER RESEARCH
- Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering
- (2014) Thomas H. Pillow et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Cytotoxic Dolastatin 10 Analogues with N-Terminal Modifications
- (2014) Andreas Maderna et al. JOURNAL OF MEDICINAL CHEMISTRY
- Preclinical Profile of the HER2-Targeting ADC SYD983/SYD985: Introduction of a New Duocarmycin-Based Linker-Drug Platform
- (2014) W. Dokter et al. MOLECULAR CANCER THERAPEUTICS
- In Vitro and In Vivo Evaluation of Cysteine and Site Specific Conjugated Herceptin Antibody-Drug Conjugates
- (2014) Dowdy Jackson et al. PLoS One
- Pyrrolobenzodiazepines (PBDs) Do Not Bind to DNA G-Quadruplexes
- (2014) Khondaker M. Rahman et al. PLoS One
- A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
- (2014) A. E. Prota et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/ -ketoglutarate-dependent dioxygenase
- (2014) A. S. Eustaquio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Two Faces of Potent Antitumor Duocarmycin-Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity
- (2013) Tanja Wirth et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The Cytotoxicity of Duocarmycin Analogues is Mediated through Alkylation of DNA, not Aldehyde Dehydrogenase 1: A Comment
- (2013) Moana Tercel et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- GC-Targeted C8-Linked Pyrrolobenzodiazepine–Biaryl Conjugates with Femtomolar in Vitro Cytotoxicity and in Vivo Antitumor Activity in Mouse Models
- (2013) Khondaker M. Rahman et al. JOURNAL OF MEDICINAL CHEMISTRY
- Remediating Cancer via Splicing Modulation
- (2013) Mark S. Butler JOURNAL OF MEDICINAL CHEMISTRY
- An Extended Pyrrolobenzodiazepine–Polyamide Conjugate with Selectivity for a DNA Sequence Containing the ICB2 Transcription Factor Binding Site
- (2013) Federico Brucoli et al. JOURNAL OF MEDICINAL CHEMISTRY
- Site-specific antibody drug conjugates for cancer therapy
- (2013) Siler Panowski et al. mAbs
- Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion
- (2013) Elsa Wagner-Rousset et al. mAbs
- Maturing antibody–drug conjugate pipeline hits 30
- (2013) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Monoclonal antibody-based therapies in cancer: Advances and challenges
- (2013) Puja Sapra et al. PHARMACOLOGY & THERAPEUTICS
- Radretumab Radioimmunotherapy in Patients with Brain Metastasis: A 124I-L19SIP Dosimetric PET Study
- (2013) G. L. Poli et al. Cancer Immunology Research
- Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells
- (2012) Tanja Wirth et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Antibody-Drug Conjugates in Cancer Therapy
- (2012) Eric L. Sievers et al. Annual Review of Medicine
- Pyrrolo[2,1-c][1,4]benzodiazepine as a Scaffold for the Design and Synthesis of Anti- Tumour Drugs
- (2012) Laura Cipolla et al. Anti-Cancer Agents in Medicinal Chemistry
- Therapeutic Potential of Amanitin-Conjugated Anti-Epithelial Cell Adhesion Molecule Monoclonal Antibody Against Pancreatic Carcinoma
- (2012) Gerhard Moldenhauer et al. JNCI-Journal of the National Cancer Institute
- DNA Damage Repair Pathways in Cancer Stem Cells
- (2012) M. Maugeri-Sacca et al. MOLECULAR CANCER THERAPEUTICS
- The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma
- (2012) Peter D Senter et al. NATURE BIOTECHNOLOGY
- The spliceosome as a target of novel antitumour drugs
- (2012) Sophie Bonnal et al. NATURE REVIEWS DRUG DISCOVERY
- A Traceless Vascular-Targeting Antibody-Drug Conjugate for Cancer Therapy
- (2011) Gonçalo J. L. Bernardes et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Antibody-Drug Conjugates of Calicheamicin Derivative: Gemtuzumab Ozogamicin and Inotuzumab Ozogamicin
- (2011) A. D. Ricart CLINICAL CANCER RESEARCH
- Antibody Fusion Proteins: Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox
- (2011) R. J. Kreitman et al. CLINICAL CANCER RESEARCH
- Antibody-Radionuclide Conjugates for Cancer Therapy: Historical Considerations and New Trends
- (2011) M. Steiner et al. CLINICAL CANCER RESEARCH
- Trastuzumab Emtansine: A Unique Antibody-Drug Conjugate in Development for Human Epidermal Growth Factor Receptor 2-Positive Cancer
- (2011) P. M. LoRusso et al. CLINICAL CANCER RESEARCH
- Antibody Conjugate Therapeutics: Challenges and Potential
- (2011) B. A. Teicher et al. CLINICAL CANCER RESEARCH
- Prodrugs for Targeted Tumor Therapies: Recent Developments in ADEPT, GDEPT and PMT
- (2011) Lutz F. Tietze et al. CURRENT PHARMACEUTICAL DESIGN
- Therapeutic potential of anticancer immunotoxins
- (2011) Swati Choudhary et al. DRUG DISCOVERY TODAY
- The development of pyrrolobenzodiazepines as antitumour agents
- (2011) John A Hartley EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Investigational antibody drug conjugates for solid tumors
- (2011) Puja Sapra et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Synthesis and Evaluation of Hydrophilic Linkers for Antibody–Maytansinoid Conjugates
- (2011) Robert Y. Zhao et al. JOURNAL OF MEDICINAL CHEMISTRY
- Observation of a Single-Stranded DNA/Pyrrolobenzodiazepine Adduct
- (2011) Khondaker M. Rahman et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- World Antibody Drug Conjugate Summit Europe
- (2011) Alain Beck et al. mAbs
- Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers
- (2011) Khondaker M. Rahman et al. NUCLEIC ACIDS RESEARCH
- A DC-81-indole conjugate agent suppresses melanoma A375 cell migration partially via interrupting VEGF production and stromal cell-derived factor-1α-mediated signaling
- (2011) Ming-Chu Hsieh et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Immunotoxins and Anticancer Drug Conjugate Assemblies: The Role of the Linkage between Components
- (2011) Franco Dosio et al. Toxins
- Synthesis of DNA-Interactive Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)
- (2010) Dyeison Antonow et al. CHEMICAL REVIEWS
- Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate
- (2010) N. M. Okeley et al. CLINICAL CANCER RESEARCH
- Gemtuzumab Ozogamicin: One Size Does Not Fit All—The Case for Personalized Therapy
- (2010) Farhad Ravandi JOURNAL OF CLINICAL ONCOLOGY
- Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines
- (2010) Barbara Gerratana MEDICINAL RESEARCH REVIEWS
- Maytansinoid-Antibody Conjugates Induce Mitotic Arrest by Suppressing Microtubule Dynamic Instability
- (2010) E. Oroudjev et al. MOLECULAR CANCER THERAPEUTICS
- Microtubule-binding agents: a dynamic field of cancer therapeutics
- (2010) Charles Dumontet et al. NATURE REVIEWS DRUG DISCOVERY
- Doxorubicin pathways
- (2010) Caroline F. Thorn et al. Pharmacogenetics and Genomics
- DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor Agents
- (2010) Khondaker M. Rahman et al. ACS Medicinal Chemistry Letters
- Design, Synthesis, and Biological Evaluation of Antibody−Drug Conjugates Comprised of Potent Camptothecin Analogues
- (2009) Patrick J. Burke et al. BIOCONJUGATE CHEMISTRY
- CMC-544 (inotuzumab ozogamicin) shows less effect on multidrug resistant cells: analyses in cell lines and cells from patients with B-cell chronic lymphocytic leukaemia and lymphoma
- (2009) Akihiro Takeshita et al. BRITISH JOURNAL OF HAEMATOLOGY
- Fanconi Anemia Proteins, DNA Interstrand Crosslink Repair Pathways, and Cancer Therapy
- (2009) Paul Andreassen et al. CURRENT CANCER DRUG TARGETS
- Limazepines A−F, Pyrrolo[1,4]benzodiazepine Antibiotics from an Indonesian Micrococcus sp.
- (2009) Serge Fotso et al. JOURNAL OF NATURAL PRODUCTS
- The Pyrrolobenzodiazepine Dimer SJG-136 Forms Sequence-Dependent Intrastrand DNA Cross-Links and Monoalkylated Adducts in Addition to Interstrand Cross-Links
- (2009) Khondaker M. Rahman et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Cancer stem cells: mirage or reality?
- (2009) Piyush B Gupta et al. NATURE MEDICINE
- Determination of the Biological Activity and Structure Activity Relationships of Drugs Based on the Highly Cytotoxic Duocarmycins and CC-1065
- (2009) Lutz Tietze et al. Toxins
- Antibody-Drug Conjugates for Cancer Therapy
- (2008) Paul J. Carter et al. CANCER JOURNAL
- A History of Cancer Chemotherapy
- (2008) Vincent T. DeVita et al. CANCER RESEARCH
- Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody-Cytotoxic Drug Conjugate
- (2008) G. D. Lewis Phillips et al. CANCER RESEARCH
- Observation of a dynamic equilibrium between DNA hairpin and duplex forms of covalent adducts of a minor groove binding agent
- (2008) Khondaker M. Rahman et al. CHEMICAL COMMUNICATIONS
- Approved monoclonal antibodies for cancer therapy
- (2008) Michael Boyiadzis et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Total Synthesis and Biological Evaluation of Tubulysin U, Tubulysin V, and Their Analogues
- (2008) Ranganathan Balasubramanian et al. JOURNAL OF MEDICINAL CHEMISTRY
- Efficacy of Selected Natural Products as Therapeutic Agents against Cancer⊥
- (2008) Sanjeev Banerjee et al. JOURNAL OF NATURAL PRODUCTS
- Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78
- (2008) M. Kotecha et al. MOLECULAR CANCER THERAPEUTICS
- Targeted Cancer Therapy: Conferring Specificity to Cytotoxic Drugs
- (2007) Ravi V. J. Chari ACCOUNTS OF CHEMICAL RESEARCH
- Selection of Reaction Additives Used in the Preparation of Monomeric Antibody−Calicheamicin Conjugates
- (2007) Irwin Hollander et al. BIOCONJUGATE CHEMISTRY
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