Chemistry and biology of tubulysins: antimitotic tetrapeptides with activity against drug resistant cancers

Total Synthesis of Tubulysin U and Its C-4 Epimer

(2013) Xiu-dong Yang et al.   Chemistry-An Asian Journal

Synthesis and structure–activity relationship studies of novel tubulysin U analogues – effect on cytotoxicity of structural variations in the tubuvaline fragment

(2013) Sreejith P. Shankar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Design, synthesis, and biological activities of triazole tubulysin V analogue

(2013) Xiudong Yang et al.   TETRAHEDRON LETTERS

Synthesis and cytotoxicity evaluation of diastereoisomers and N-terminal analogues of tubulysin-U

(2013) P. Sreejith Shankar et al.   TETRAHEDRON LETTERS

Heterologous Expression and Genetic Engineering of the Tubulysin Biosynthetic Gene Cluster Using Red/ET Recombineering and Inactivation Mutagenesis

(2012) Yi Chai et al.   CHEMISTRY & BIOLOGY

Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy

(2012) Jürgen Eirich et al.   Molecular BioSystems

A straightforward click-approach towards pretubulysin-analogues

(2012) Jens L. Burkhart et al.   RSC Advances

Acid mediated formation of an N-acyliminium ion from tubulysins: A new methodology for the synthesis of natural tubulysins and their analogs

(2011) Iontcho R. Vlahov et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Syntheses and Evaluation of Simplified Pretubulysin Analogues

(2011) Jens L. Burkhart et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The Multiple Multicomponent Approach to Natural Product Mimics: Tubugis, N-Substituted Anticancer Peptides with Picomolar Activity

(2011) Orlando Pando et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin

(2010) Karel Kubicek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline

(2010) Taku Shibue et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of 23 Natural Tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004

(2010) Yi Chai et al.   CHEMISTRY & BIOLOGY

Total Syntheses of Tubulysins

(2010) Taku Shibue et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chemotherapeutic Evaluation of a Synthetic Tubulysin Analogue-Dendrimer Conjugate in C26 Tumor Bearing Mice

(2010) William C. Floyd et al.   ChemMedChem

Synthesis and Biological Analysis of Prostate-Specific Membrane Antigen-Targeted Anticancer Prodrugs

(2010) Sumith A. Kularatne et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dendrimers as Carriers for Delivery of Chemotherapeutic Agents

(2009) Scott H. Medina et al.   CHEMICAL REVIEWS

Synthesis and Biological Evaluation of Pretubulysin and Derivatives

(2009) Angelika Ullrich et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Toward Tubulysin: Gram-Scale Synthesis of Tubuvaline-Tubuphenylalanine Fragment

(2009) Srivari Chandrasekhar et al.   JOURNAL OF ORGANIC CHEMISTRY

In Vivo Structural Activity and Optimization Studies of Folate−Tubulysin Conjugates

(2009) Joseph A. Reddy et al.   MOLECULAR PHARMACEUTICS

First Total Synthesis of Tubulysin B

(2009) Orlando Pando et al.   ORGANIC LETTERS

Stereoselective synthesis of tubuvaline methyl ester and tubuphenylalanine, components of tubulysins, tubulin polymerization inhibitors

(2009) Taku Shibue et al.   TETRAHEDRON LETTERS

Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part II: Folic acid conjugates of tubulysins and their hydrazides

(2008) Iontcho R. Vlahov et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives

(2008) Ranganathan Balasubramanian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Folate Targeting Enables Durable and Specific Antitumor Responses from a Therapeutically Null Tubulysin B Analogue

(2008) C. P. Leamon et al.   CANCER RESEARCH

Polymeric Tubulysin-Peptide Nanoparticles with Potent Antitumor Activity

(2008) T. Schluep et al.   CLINICAL CANCER RESEARCH

Cytotoxic Simplified Tubulysin Analogues

(2008) Bhooma Raghavan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis and Biological Evaluation of Tubulysin U, Tubulysin V, and Their Analogues

(2008) Ranganathan Balasubramanian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expedient Synthesis ofN-Methyl Tubulysin Analogues with High Cytotoxicity

(2008) Andrew W. Patterson et al.   JOURNAL OF ORGANIC CHEMISTRY