The development of pyrrolobenzodiazepines as antitumour agents

Pyrrolo[2,1-c][1,4]benzodiazepine as a Scaffold for the Design and Synthesis of Anti- Tumour Drugs

(2012) Laura Cipolla et al.   Anti-Cancer Agents in Medicinal Chemistry

SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity

(2010) J. A. Hartley et al.   CANCER RESEARCH

Inhibition of Carboplatin-Induced DNA Interstrand Cross-link Repair by Gemcitabine in Patients Receiving these Drugs for Platinum-Resistant Ovarian Cancer

(2010) J. A. Ledermann et al.   CLINICAL CANCER RESEARCH

Antibody–drug conjugates: targeted drug delivery for cancer

(2010) Stephen C Alley et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Structure−Activity Relationships of Monomeric C2-Aryl Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Antitumor Agents

(2010) Dyeison Antonow et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate

(2009) Philip W. Howard et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A phase I trial of SJG-136 (NSC#694501) in advanced solid tumors

(2009) Yelena Y. Janjigian et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugate (IN6CPBD) has better efficacy and superior safety than the mother compound DC-81 in suppressing the growth of established melanoma in vivo

(2009) Chih-Hung Lee et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Phase I Study of Sequence-Selective Minor Groove DNA Binding Agent SJG-136 in Patients with Advanced Solid Tumors

(2009) D. Hochhauser et al.   CLINICAL CANCER RESEARCH

DNA interstrand crosslink repair in mammalian cells

(2009) Kevin M. McCabe et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Pyrrolobenzodiazepine Dimer SJG-136 Forms Sequence-Dependent Intrastrand DNA Cross-Links and Monoalkylated Adducts in Addition to Interstrand Cross-Links

(2009) Khondaker M. Rahman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pyrrolo[2,1-c][1,4]benzodiazepine-β-glucuronide prodrugs with a potential for selective therapy of solid tumors by PMT and ADEPT strategies

(2008) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An asymmetric C8/C8′-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs

(2008) Arnaud C. Tiberghien et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS