Fluorine-modified sialyl-Tn-CRM197 vaccine elicits a robust immune response

Syntheses and Immunological Evaluation of Self-Adjuvanting Clustered N -Acetyl and N -Propionyl Sialyl-Tn Combined with a T-helper Cell Epitope as Antitumor Vaccine Candidates

(2018) Tsung-Che Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy

(2017) Srinivasa Reddy Bonam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A cancer vaccine based on fluorine-modified sialyl-Tn induces robust immune responses in a murine model

(2017) Chengcheng Song et al.   Oncotarget

Synthesis and immunological evaluation of N-acyl modified Tn analogues as anticancer vaccine candidates

(2016) Chengcheng Song et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Evaluation of Glycoconjugates ComprisingN-Acyl-Modified Thomsen-Friedenreich Antigens as Anticancer Vaccines

(2016) Shuang Sun et al.   ChemMedChem

Sialyl-Tn Polysaccharide A1 as an Entirely Carbohydrate Immunogen: Synthesis and Immunological Evaluation

(2016) Mengchao Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Improvement of the immune efficacy of carbohydrate vaccines by chemical modification on the GM3 antigen

(2015) Xiu-Jing Zheng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthetic and immunological studies of N-acyl modified S-linked STn derivatives as anticancer vaccine candidates

(2015) Chang-Xin Huo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Cancer Therapeutic Vaccine based on Clustered Tn-Antigen Mimetics Induces Strong Antibody-Mediated Protective Immunity

(2014) Barbara Richichi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Immunogenicity Study of Globo H Analogues with Modification at the Reducing or Nonreducing End of the Tumor Antigen

(2014) Hsin-Yu Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effect of different adjuvant formulations on the immunogenicity and protective effect of a live Mycoplasma hyopneumoniae vaccine after intramuscular inoculation

(2014) Qiyan Xiong et al.   VACCINE

Survival Advantage in Patients with Metastatic Breast Cancer Receiving Endocrine Therapy plus Sialyl Tn-KLH Vaccine: Post Hoc Analysis of a Large Randomized Trial

(2013) Nuhad K. Ibrahim et al.   Journal of Cancer

Combining synthetic carbohydrate vaccines with cancer cell glycoengineering for effective cancer immunotherapy

(2012) Lei Qiu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunization with N-propionyl polysialic acid–KLH conjugate in patients with small cell lung cancer is safe and induces IgM antibodies reactive with SCLC cells and bactericidal against group B meningococci

(2011) Lee M. Krug et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Innate iNKT cell help to B cells: fast but does not last

(2011) Agnès Lehuen et al.   NATURE IMMUNOLOGY

Phase III Multicenter Clinical Trial of the Sialyl-TN (STn)-Keyhole Limpet Hemocyanin (KLH) Vaccine for Metastatic Breast Cancer

(2011) D. Miles et al.   ONCOLOGIST

Avidity of CD1d-ligand-receptor ternary complex contributes to T-helper 1 (Th1) polarization and anticancer efficacy

(2011) T.-N. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancement of the Immunogenicity of Synthetic Carbohydrate Vaccines by Chemical Modifications of STn Antigen

(2010) Fan Yang et al.   ACS Chemical Biology

In Vivo Protection Provided by a Synthetic New Alpha-Galactosyl Ceramide Analog against Bacterial and Viral Infections in Murine Models

(2010) K.-H. Lin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Carbohydrate vaccines: developing sweet solutions to sticky situations?

(2010) Rena D. Astronomo et al.   NATURE REVIEWS DRUG DISCOVERY

A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity

(2010) K. J. Doores et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of N-modified sTn analogs and evaluation of their immunogenicities by microarray-based immunoassay

(2010) Sk Sahabuddin et al.   TETRAHEDRON

Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model

(2009) S Julien et al.   BRITISH JOURNAL OF CANCER

Recent development in carbohydrate-based cancer vaccines

(2009) Zhongwu Guo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Rational chemical design of the carbohydrate in a glycoconjugate vaccine enhances IgM-to-IgG switching

(2008) H.-K. Guttormsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A clinical trial examining the effect of increased total CRM197 carrier protein dose on the antibody response to Haemophilus influenzae type b CRM197 conjugate vaccine

(2008) Vytautas Usonis et al.   VACCINE

Diphtheria toxin mutant CRM197 is an inhibitor of protein synthesis that induces cellular toxicity

(2007) Jian Qiao et al.   TOXICON