Article
Immunology
Giuditta Guerrini, Antonio Vivi, Sabrina Gioria, Jessica Ponti, Davide Magri, Arnd Hoeveler, Donata Medaglini, Luigi Calzolai
Summary: Physicochemical properties of adjuvant-protein antigen complexes impact vaccine efficacy and safety, and a multi-staged characterization strategy has been developed for accurate assessment of nanoaluminum-ovalbumin complex, which can be adapted for various adjuvant-protein antigen combinations to control quality and improve immunological outcomes of vaccines.
Review
Pharmacology & Pharmacy
Neftali Ortega Alarcon, Maddy Jaramillo, Heidi M. Mansour, Bo Sun
Summary: This review summarizes the current progress of therapeutic subunit vaccines for cancer immunotherapy, including the classification of tumor antigens and the bioinformatic approaches for identifying tumor neoantigens. The targeting adjuvants based on pattern recognition receptors (PRRs) and their delivery platforms are extensively discussed, emphasizing the importance of the interplay between multiple adjuvants and their combined delivery in cancer immunotherapy.
Review
Immunology
Ting Huang, Li Liu, Zheng Lv, Kelei Zhao, Qiong Yi, Jing Zhang
Summary: Lung cancer is a major cause of patient deaths globally, and despite advancements in tumor immunotherapy, the 5-year survival rate for lung cancer patients remains low. The development of effective vaccines for lung cancer is crucial, and DNA vaccines are considered a promising strategy to activate the immune system against lung cancer due to their ability to induce both humoral and cellular immune responses.
Review
Pharmacology & Pharmacy
Qing He, Hua Gao, Dejiang Tan, Heng Zhang, Jun-zhi Wang
Summary: mRNA vaccines are well-tolerated by patients and offer flexibility in the choice of encoded molecules. The approval of the first mRNA-based COVID-19 vaccine by the FDA in 2021 has sparked enthusiasm for mRNA vaccine research and development. mRNA cancer vaccines have become a hot topic and have undergone rapid development in recent years.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Chemistry, Physical
Aihua Qu, Maozhong Sun, Liguang Xu, Liqiang Liu, Lingling Guo, Panpan Chen, Qing Wang, Zhiyong Du, Zhimeng Wu, Chuanlai Xu, Hua Kuang
Summary: Chiral nanomaterials play a crucial role in the field of vaccines by promoting antigen presentation and activating the immune system for tumor immunotherapy. However, there are still challenges in this research, such as finding better synthesis methods and addressing the issue of immune system regulation.
Editorial Material
Immunology
Abu Salim Mustafa
Summary: Efforts towards developing new vaccines against TB mainly focus on using Mycobacterium tuberculosis antigens as subunit vaccines, requiring appropriate adjuvants and delivery systems to induce immune responses. Additionally, studies have examined the pathogenesis of BCG in children and explored the potential use of BCG as a vaccine against asthma, alongside different adjuvants and delivery systems in inducing protective immune responses after immunization with subunit vaccines.
Review
Immunology
Yue Zhao, Alexey Baldin, Orkhan Isayev, Jens Werner, Andrey A. Zamyatnin, Alexandr Bazhin
Summary: Cancer vaccines utilize the host's immune system specificity to eliminate tumor cells, with antigen selection and application playing a critical role in efficacy. Tumor-associated antigens and tumor-specific antigens have different characteristics and applications in vaccine development.
Review
Pharmacology & Pharmacy
Beata Biri-Kovacs, Zoltan Banoczi, Anitha Tummalapally, Ildiko Szabo
Summary: Skin cancer is the most common type of cancer, with melanoma being a leading cause of skin cancer deaths. Recent advancements in understanding melanoma tumorigenesis and its interaction with the immune system have led to the development of new therapeutic strategies. Peptide-based vaccines, which target tumor antigens and activate immune responses, have shown promise in treating advanced melanoma. However, the immunogenicity of peptide antigens can be enhanced through synthetic modifications, adjuvants, and delivery systems. This review summarizes the various chemical approaches for developing effective peptide-based vaccines for immunotherapy in advanced melanoma.
Article
Engineering, Biomedical
Francisca Diniz, Maria Azevedo, Flavia Sousa, Hugo Osorio, Diana Campos, Paula Sampaio, Joana Gomes, Bruno Sarmento, Celso A. Reis
Summary: Drug delivery using nanoparticles has the potential for cancer therapy, particularly for gastric cancer. This study developed surface-functionalized nanoparticles with specific antibodies, which effectively recognized cancer cells expressing the target antigen under flow conditions. These findings highlight the potential use of such nanoparticles for drug delivery in cancer.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Francisca Diniz, Sofia Lamas, Hugo Osorio, Paulo Aguiar, Daniela Freitas, Fatima Gartner, Bruno Sarmento, Celso A. Reis, Joana Gomes
Summary: This study demonstrates the potential of using nanoparticles targeting STn for delivering FRT as a therapeutic approach in gastric cancer. The nanoparticles effectively reduced tumor growth, cell proliferation, and tumor necrosis in vivo.
ACTA BIOMATERIALIA
(2023)
Review
Oncology
Ryan Chang, James L. Gulley, Lawrence Fong
Summary: Immunotherapies, such as immune checkpoint inhibitors and cellular therapies, have revolutionized cancer treatment, but the development of successful cancer vaccines remains challenging. Only two vaccines have shown improved survival in advanced disease: sipuleucel-T and talimogene laherparepvec, which target specific antigens and utilize tumors in situ to prime responses. In this review, we examine the challenges and opportunities in developing therapeutic cancer vaccines.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Chemistry, Multidisciplinary
Yang Bo, Hua Wang
Summary: Cancer immunotherapies, including therapeutic cancer vaccines, have revolutionized cancer treatment. However, the limited efficacy of cancer vaccines, especially for immunologically cold solid tumors, remains a challenge. In situ cancer vaccines, particularly biomaterials-based vaccines, have emerged as a promising approach to address this challenge by generating endogenous antigens directly from tumors. This review provides an overview of biomaterials-based in situ cancer vaccines, discussing their design criteria and potential applications.
ADVANCED MATERIALS
(2023)
Review
Immunology
Si-Yuan Zhu, Ke-Da Yu
Summary: Breast cancer is the most commonly diagnosed cancer worldwide, with relapse and metastasis posing significant challenges. Innovative therapeutic strategies, such as cancer vaccines, are needed to address these challenges. Although current results have been disappointing, recent studies suggest the potential of combining vaccines with other treatments for breast cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sara Feola, Salvatore Russo, Beatriz Martins, Alessandra Lopes, Gaelle Vandermeulen, Vinciane Fluhler, Camilla De Giorgi, Manlio Fusciello, Sari Pesonen, Erkko Yloesmaeki, Gabriella Antignani, Jacopo Chiaro, Firas Hamdan, Michaela Feodoroff, Mikaela Groenholm, Vincenzo Cerullo
Summary: Oncolytic viruses (OVs) can work as in situ cancer vaccines by directly lysing cancer cells and releasing tumor antigens. However, this mechanism may not always induce a strong T cell response. Genetically modified OVs encoding tumor antigens or coating OVs with tumor antigens can enhance the priming efficiency. In this study, both approaches were tested and characterized for their efficacy as cancer vaccines. Both genetically modified oncolytic adenovirus and PeptiCRAd elicited T cells-specific anti-tumor responses, but PeptiCRAd showed advantages in fast presentation of tumor antigens and adaptability for personalized cancer vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Charlotte Sorieul, Francesco Papi, Filippo Carboni, Simone Pecetta, Sanjay Phogat, Roberto Adamo
Summary: Carbohydrates are widely expressed on the surface of cells and play important roles in immune responses and cancer progression. Vaccines and monoclonal antibodies targeting specific carbohydrates have been developed, but the immune tolerance associated with these glycans poses challenges. New strategies are being explored to enhance carbohydrate-based cancer therapies.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Wataru Nihei, Masakazu Nagafuku, Hirotaka Hayamizu, Yuta Odagiri, Yumi Tamura, Yui Kikuchi, Lucas Veillon, Hirotaka Kanoh, Kei-ichiro Inamori, Kenta Arai, Kazuya Kabayama, Koichi Fukase, Jin-ichi Inokuchi
JOURNAL OF LIPID RESEARCH
(2018)
Article
Chemistry, Multidisciplinary
Julinton Sianturi, Yoshiyuki Manabe, Hao-Sheng Li, Li-Ting Chiu, Tsung-Che Chang, Kento Tokunaga, Kazuya Kabayama, Masahiro Tanemura, Shinji Takamatsu, Eiji Miyoshi, Shang-Cheng Hung, Koichi Fukase
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Biochemistry & Molecular Biology
Kazuya Kabayama
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Yoshiyuki Manabe, Roberta Marchetti, Yohei Takakura, Masahiro Nagasaki, Wataru Nihei, Tomoyuki Takebe, Katsunori Tanaka, Kazuya Kabayama, Fabrizio Chiodo, Shinya Hanashima, Yoshihiro Kamada, Eiji Miyoshi, Hari Prasad Dulal, Yoshiki Yamaguchi, Yoshiyuki Adachi, Naohito Ohno, Hiroshi Tanaka, Alba Silipo, Koichi Fukase, Antonio Molinaro
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Chemistry, Multidisciplinary
Qi Feng, Yoshiyuki Manabe, Kazuya Kabayama, Taku Aiga, Asuka Miyamoto, Shino Ohshima, Yoshie Kametani, Koichi Fukase
CHEMISTRY-AN ASIAN JOURNAL
(2019)
Article
Biochemistry & Molecular Biology
Makoto Taniguchi, Yoshibumi Ueda, Michiko Matsushita, Shingo Nagaya, Chieko Hashizume, Kenta Arai, Kazuya Kabayama, Koichi Fukase, Ken Watanabe, Lusi Oka Wardhani, Kazuhiko Hayashi, Toshiro Okazaki
Article
Biochemistry & Molecular Biology
Hirotaka Kanoh, Takahiro Nitta, Shinji Go, Kei-ichiro Inamori, Lucas Veillon, Wataru Nihei, Mayu Fujii, Kazuya Kabayama, Atsushi Shimoyama, Koichi Fukase, Umeharu Ohto, Toshiyuki Shimizu, Taku Watanabe, Hiroki Shindo, Sorama Aoki, Kenichi Sato, Mika Nagasaki, Yutaka Yatomi, Naoko Komura, Hiromune Ando, Hideharu Ishida, Makoto Kiso, Yoshihiro Natori, Yuichi Yoshimura, Asia Zonca, Anna Cattaneo, Marilena Letizia, Maria Ciampa, Laura Mauri, Alessandro Prinetti, Sandro Sonnino, Akemi Suzuki, Jin-ichi Inokuchi
Article
Chemistry, Multidisciplinary
Taku Aiga, Yoshiyuki Manabe, Keita Ito, Tsung-Che Chang, Kazuya Kabayama, Shino Ohshima, Yoshie Kametani, Ayane Miura, Hiroto Furukawa, Hiroshi Inaba, Kazunori Matsuura, Koichi Fukase
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Biochemistry & Molecular Biology
Kenta Arai, Yoshimi Kanie, Osamu Kanie, Koichi Fukase, Kazuya Kabayama
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Review
Chemistry, Organic
Yoshiyuki Manabe, Atushi Shimoyama, Kazuya Kabayama, Koichi Fukase
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN
(2020)
Article
Chemistry, Organic
Kenta Arai, Atsuko Ohtake, Shusaku Daikoku, Katsuhiko Suzuki, Yukishige Ito, Kazuya Kabayama, Koichi Fukase, Yoshimi Kanie, Osamu Kanie
ORGANIC & BIOMOLECULAR CHEMISTRY
(2020)
Proceedings Paper
Green & Sustainable Science & Technology
Yuka Nimura, Kazuya Kabayama, Yuya Asahina, Shinya Hanashima, Hironobu Hojo, Michio Murata, Koichi Fukase
IRAGO CONFERENCE 2018: A 360-DEGREE OUTLOOK ON CRITICAL SCIENTIFIC AND TECHNOLOGICAL CHALLENGES FOR A SUSTAINABLE SOCIETY
(2019)
Proceedings Paper
Green & Sustainable Science & Technology
K. Arai, K. Kabayama, J. Ono, H. Nakamura, H. Kimura, K. Fukase
IRAGO CONFERENCE 2018: A 360-DEGREE OUTLOOK ON CRITICAL SCIENTIFIC AND TECHNOLOGICAL CHALLENGES FOR A SUSTAINABLE SOCIETY
(2019)
Meeting Abstract
Oncology
Kazuko Kaneda, ZiJian Zhang, Yoshiyuki Manabe, Atsushi Shimoyama, Kazuya Kabayama, Yoshikatsu Kanai, Koichi Fukase, Atsushi Shinohara