Article
Chemistry, Multidisciplinary
Lingqiang Gao, Qinghai Lian, Leilei Ma, Shiwei Su, Menglan Yang, Yuan Fang, Zhongqiu Liu, Xiang Luo, Guochao Liao
Summary: An efficient strategy for constructing RC-529 and its derivatives has been established, with four conjugates of RC-529 derivatives with Tn antigen inducing strong T cell dependent immune responses in mice and showing specific cytotoxicity towards Tn-overexpressing cancer cells. This suggests RC-529 as a potential platform for the development of new vaccine carriers with self-adjuvanting properties for cancer treatment, supported by preliminary structure-activity relationship analysis.
CHINESE CHEMICAL LETTERS
(2021)
Review
Biochemistry & Molecular Biology
MacLean C. Sellars, Catherine J. Wu, Edward F. Fritsch
Summary: This article reviews the immunologic concepts of cancer vaccines and highlights the challenges they face. Recent technological advances provide new opportunities for studying cancer vaccines, such as neoantigen prediction and genetically engineered models.
Review
Oncology
Ivan Y. Filin, Kristina V. Kitaeva, Catrin S. Rutland, Albert A. Rizvanov, Valeriya V. Solovyeva
Summary: The development of immunotherapeutic methods for oncological diseases has improved the effectiveness of standard therapies, with dendritic cell vaccines showing promise in expanding treatment options and improving indicators for cancer patients in clinical trials.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Wen-Hao Li, Jing-Yun Su, Yan-Mei Li
Summary: Cancer vaccines aim to enhance tumor-specific immune responses by engaging both T-cell and B-cell immunity. Different factors, including antigen selection, immune activation, vaccine delivery, and repeatable vaccination, should be considered for the rational design of therapeutic cancer vaccines. Chemical strategies such as adjuvants and nanomaterials play crucial roles in advancing the development of effective T-cell- and B-cell-based cancer vaccines.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Review
Chemistry, Physical
Aihua Qu, Maozhong Sun, Liguang Xu, Liqiang Liu, Lingling Guo, Panpan Chen, Qing Wang, Zhiyong Du, Zhimeng Wu, Chuanlai Xu, Hua Kuang
Summary: Chiral nanomaterials play a crucial role in the field of vaccines by promoting antigen presentation and activating the immune system for tumor immunotherapy. However, there are still challenges in this research, such as finding better synthesis methods and addressing the issue of immune system regulation.
Article
Biochemistry & Molecular Biology
Song Bai, Hang Gao, Lin-Tong-Qing Tan, Lulu Yao, Xin Meng, Yongzhong Zhang
Summary: In this study, a novel conjugate vaccine Tn-BSA-CTS with chitotriose as built-in adjuvant was synthesized, and the effect of adjuvant chitotriose was evaluated. The immunological evaluations showed that Tn-BSA-CTS could stimulate the highest titers of IgG antibodies (102,400) and significantly enhance both humoral and cellular immunity. These results demonstrate the potential of CTS as a novel vaccine adjuvant and suggest that the covalent linkage of tumor vaccine to CTS could be an effective strategy to enhance the efficacy against cancer.
CARBOHYDRATE RESEARCH
(2023)
Article
Immunology
David Taylor, Christian T. T. Meyer, Diana Graves, Rupashree Sen, Juan Fu, Emily Tran, Bilal Mirza, Gabriel Rodriguez, Cara Lang, Hanwen Feng, Vito Quaranta, John T. T. Wilson, Young J. J. Kim, Michael J. J. Korrer
Summary: With the clinical approval of T-cell-dependent immune checkpoint inhibitors, therapeutic cancer vaccines have re-emerged as a promising immunotherapy. By optimizing the synergy of immunostimulatory adjuvants, cancer vaccines can be formulated to enhance the immune response and improve efficacy. The study demonstrates that the MuSyC-extended approach can be used to optimize cancer vaccine formulations and improve immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Amanda L. Huff, Elizabeth M. Jaffee, Neeha Zaidi
Summary: The success of mRNA vaccines in protecting against COVID-19 has implications for their potential use in cancer therapeutics, and this article discusses the lessons learned and adaptations needed for optimizing mRNA technology in cancer treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Chemistry, Medicinal
Rakesh Pahwa, Jatin Chhabra, Raj Kumar, Rakesh Narang
Summary: This paper discusses key approaches to address resistance associated with melphalan, as well as chemical and formulation developments to enhance its characteristics and targeted profile. The rationale of the article also summarizes recent analytical methods, structure-activity relationship, pharmacokinetics, interactions, potential adverse effects, and medicinal updates of melphalan, including synthetic developments, derivatives, conjugates, and prodrugs, along with encouraging insights and research findings.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Engineering, Environmental
Xiaoxue Xie, Ting Song, Yi Feng, Hanxi Zhang, Geng Yang, Chunhui Wu, Fengming You, Yiyao Liu, Hong Yang
Summary: Cancer immunotherapy, such as cancer vaccines and immune checkpoint blockade, has shown promise in specifically targeting cancer cells. However, there are challenges including side effects, long processing time, immunosuppressive tumor microenvironment, and high cost. Multifunctional nanovaccines based on nanotechnology can overcome these challenges by efficiently delivering tumor antigens and adjuvants and inducing specific antitumor immune responses.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Qi Feng, Xiaoyue Yu, Yixue Wang, Shiyang Li, Yang Yang
Summary: Breast cancer is the leading cause of cancer-related deaths among women globally, with HER2 overexpression significantly associated with higher breast tumor proliferation rates. A self-adjuvanting MFCH401-conjugated multiple-component anti-HER2 cancer vaccine was designed to induce a stronger and more durable immune response, showing enhanced immunogenicity compared to previous two-component conjugates.
Review
Immunology
Zihan Deng, Lisen Lu, Binghui Li, Xiujuan Shi, Honglin Jin, Weidong Hu
Summary: Inflammation is a critical feature in all stages of tumor development. Inflammasomes, as an important component of the inflammatory response and innate immune system, regulate infiltrating immune cell activity by signaling the secretion of different cytokines and chemokines. The expression patterns of inflammasomes vary across tumor types and stages, and understanding their specific effects is crucial for developing inflammasome-targeting drugs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yashavantha L. Vishweshwaraiah, Nikolay V. Dokholyan
Summary: Immunotherapy has emerged as a breakthrough in cancer treatment, and mRNA vaccines have shown great potential in cancer immunotherapy. Recent technological advances have accelerated the development and application of mRNA cancer vaccines. This review highlights various cancer vaccine platforms, focusing on nucleic acid vaccines, and discusses the design and delivery strategies for mRNA cancer vaccines, as well as the limitations and future challenges.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Michael A. Morse, Erika J. Crosby, Jeremy Force, Takuya Osada, Amy C. Hobeika, Zachary C. Hartman, Peter Berglund, Jonathan Smith, H. Kim Lyerly
Summary: Therapeutic cancer vaccines use different platforms, such as messenger RNAs (mRNA), for antigen delivery. Self-replicating RNAs (srRNA) increase epitope expression and have been derived from positive-strand RNA viruses. Clinical stage srRNA vectors have shown positive results in encoding tumor antigens and adverse events have been minimal. Recent development of fully synthetic srRNA technologies shows promise for future vaccines.
CANCER GENE THERAPY
(2023)
Article
Pharmacology & Pharmacy
Deying Yang, Xiang Luo, Qinghai Lian, Lingqiang Gao, Chengxin Wang, Xiaoxiao Qi, Rong Zhang, Zhongqiu Liu, Guochao Liao
Summary: This study presents a new strategy for self-adjuvanting vaccine development using different types of covalently-linked immunostimulants as the carrier molecule. A three-component vaccine (MPLA-Tn-KRN7000) containing the TLR4 ligand MPLA and the iNKT cell agonist KRN7000 was designed and synthesized, expanding the field of fully synthetic self-adjuvanting vaccines. The immunological evaluation showed that MPLA-Tn-KRN7000 induced robust Tn-specific and T cell-dependent immunity.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Multidisciplinary
Solene Gentil, Carlo Pifferi, Pierre Rousselot-Pailley, Thierry Tron, Olivier Renaudet, Alan Le Goff
Summary: Carbon nanotube electrodes were modified with ferrocene and laccase using click reactions strategies involving diazonium functionalization and oxime ligation, achieving a high surface coverage of ferrocene. The immobilization of active multicopper enzymes, laccases, on surfaces via copper(I)-catalyzed azide-alcyne cycloaddition was also successful, highlighting the efficiency of oxime-ligated dendrimers or cyclopeptides. Despite controlled orientation, this immobilization strategy was found to impact electron tunneling with enzyme active sites.
Article
Biochemical Research Methods
Harlei Martin, David Goyard, Anatte Margalit, Kyle Doherty, Olivier Renaudet, Kevin Kavanagh, Trinidad Velasco-Torrijos
Summary: The study found that a specific divalent galactoside glycomimetic 1 has inhibitory effects on the adhesion and biofilm formation of Candida albicans. The multivalent presentations of glycomimetic 1 showed varying effectiveness in inhibiting yeast adhesion and biofilm formation, with the core scaffold significantly influencing the activity of lower valency conjugates.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Rene Buchet, Camille Tribes, Valentine Rouaix, Bastien Doumeche, Michele Fiore, Yuqing Wu, David Magne, Saida Mebarek
Summary: The study found that high levels of ATP released by cells near atherosclerosis plaques generate inorganic phosphate (Pi) instead of the mineralization inhibitor PPi, which may exacerbate plaque calcification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Francois Bulteau, Michel Thepaut, Maxime Henry, Amandine Hurbin, Laetitia Vanwonterghem, Corinne Vives, Aline Le Roy, Christine Ebel, Olivier Renaudet, Franck Fieschi, Jean-Luc Coll
Summary: This study found that recombinant MGL fragments can efficiently target Tn-positive human tumors without inducing toxicity, making it a promising candidate for in vivo diagnosis and imaging of human tumors and potentially for therapeutic applications.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
David Goyard, Benoit Roubinet, Federica Vena, Ludovic Landemarre, Olivier Renaudet
Summary: Click chemistry allows for the creation of a diverse range of multivalent glycoconjugates to study carbohydrate-protein interactions and discover high affinity ligands. The study shows that multivalent and multispecific neoGPs have the potential to effectively interact with specific lectins and combat resistant pathogens.
Article
Materials Science, Multidisciplinary
Giacomo Reina, Amalia Ruiz, Barbara Richichi, Giacomo Biagiotti, Gina E. Giacomazzo, Lucas Jacquemin, Yuta Nishina, Cecilia Menard-Moyon, Wafa T. Al-Jamal, Alberto Bianco
Summary: This study investigates the functionalisation of graphene oxide (GO) with a BODIPY derivative for glutathione (GSH) depletion and photodynamic therapy (PDT). Results show that GO-BODIPY can efficiently deplete intracellular GSH and generate reactive oxygen species, which significantly reduces cell viability after irradiation. The biocompatibility of GO and GO-BODIPY is also demonstrated in prostate adenocarcinoma cells.
Editorial Material
Biology
Emiliano Altamura, Michele Fiore
Article
Chemistry, Organic
Giacomo Biagiotti, Laura Legnani, Giusi Aresta, Maria A. Chiacchio, Barbara Richichi
Summary: This study describes the synthesis and reactivity of a new class of electron-poor heterodienes in an [4+2] inverse electron demand hetero Diels-Alder reaction. The highly reactive electrophiles allow for the selective synthesis of unprecedented benzo-thiazine glyco-fused derivatives. Experimental and computational data confirm the feasibility of the reaction.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Fryni Skorda, Carolina Chieffo, Michele Fiore
Summary: This article discusses the phenomenon of symmetry breaking between racemic mixtures and homo-chirality, and suggests using chemical models such as phospholipids to simulate conditions and study homo-chiral symmetry breaking.
Article
Chemistry, Medicinal
Jacopo Tricomi, Luca Landini, Valentina Nieddu, Ugo Cavallaro, Jillian G. Baker, Athanasios Papakyriakou, Barbara Richichi
Summary: Over the past decade, the biomedical applications of molecules that can modulate beta-adrenergic signaling have gained increasing attention, especially in cancer treatment. However, the identification of selective beta-adrenergic receptor (beta-AR) ligands for pharmacological studies and drug development remains a challenging task due to the complexity and specificity requirements of beta-ARs. In this study, we synthesized and evaluated a series of structurally diverse compounds (MC) based on the aryloxy-propanolamine scaffold of SR59230A, aiming to gain insights into the structure-activity relationships of the three beta-AR subtypes. The results provide valuable information on key structural elements and substituents that control the activity and selectivity of these compounds, which could facilitate the development of selective beta-AR drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Heitor Gobbi Sebinelli, Luiz Henrique Silva Andrilli, Bruno Zoccaratto Favarin, Marcos Aantonio Eufrasio Cruz, Mayte Bolean, Michele Fiore, Carolina Chieffo, David Magne, Andrea Magrini, Ana Paula Ramos, Jose Luis Millan, Saida Mebarek, Rene Buchet, Massimo Bottini, Pietro Ciancaglini
Summary: The study indicates that Na,K-ATPase (NKA) may play a role in mineral formation inside Matrix vesicles (MVs), while tissue-nonspecific alkaline phosphatase (TNAP) serves as the main ATP hydrolyzing enzyme. Various inhibitors have different effects on ATP hydrolysis in MVs, affecting mineralization to some extent, with TNAP playing a major role in mineral formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Giacomo Reina, Giovanni Mariano Beneventi, Ramandeep Kaur, Giacomo Biagiotti, Alejandro Cadranel, Cecilia Menard-Moyon, Yuta Nishina, Barbara Richichi, Dirk M. Guldi, Alberto Bianco
Summary: Covalent functionalization of graphene oxide (GO) with boron dipyrromethenes (BODIPYs) was achieved, resulting in two different GO-BODIPY conjugates with different properties. The use of a long, flexible spacer led to strong electronic GO-BODIPY interactions, affecting light absorption and excitation. On the other hand, a short, rigid spacer resulted in minor electronic interactions and selective excitation of PBA-BODIPY, allowing the investigation of excited state interactions. Additionally, reversible covalent linkage between GO and PBA-BODIPY enabled slow release and imaging.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Irene Herrera-Gonzalez, Manuel Gonzalez-Cuesta, Michel Thepaut, Eugenie Laigre, David Goyard, Javier Rojo, Jose M. Garcia Fernandez, Franck Fieschi, Olivier Renaudet, Pedro M. Nieto, Carmen Ortiz Mellet
Summary: The carbohydrate chemical mimicry of sp2-iminosugars enables the synthesis of high-mannose-type oligosaccharide analogs whose solution and lectin bound conformations match those of the natural partners. The ability to finely modulate the binding affinity and selectivity towards specific lectins by incorporating the OMJ sp2-iminosugar caps offers potential applications in various fields.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
David Goyard, Angela Martin-Serrano Ortiz, Didier Boturyn, Olivier Renaudet
Summary: This review summarizes the synthetic strategies of using click chemistry to decorate synthetic multivalent scaffolds with glycans. It discusses the potential of multiple copies of glycans conjugated to cyclopeptide scaffolds (multivalent glycocyclopeptides) to interact with carbohydrate binding proteins and stimulate immunity against tumor cells.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Kyle C. Martin, Jacopo Tricomi, Francisco Corzana, Ana Garcia-Garcia, Laura Ceballos-Laita, Thomas Hicks, Serena Monaco, Jesus Angulo, Ramon Hurtado-Guerrero, Barbara Richichi, Robert Sackstein
Summary: Custom-modifying cell surface glycans shows promise in selectively inhibiting specific sugar displays, offering potential for innovative disease treatments. Surprising STD NMR studies indicate that the mimetic does not compete with GDP-fucose at the enzymatic binding site.
CHEMICAL COMMUNICATIONS
(2021)
