Key roles of Rho GTPases, YAP, and Mutant P53 in anti‐neoplastic effects of statins

Simvastatin and atorvastatin as inhibitors of proliferation and inducers of apoptosis in human cholangiocarcinoma cells

(2016) Benjaporn Buranrat et al.   LIFE SCIENCES

Statin Use and Its Impact on Survival in Pancreatic Cancer Patients

(2016) Hee Seung Lee et al.   MEDICINE

Statins improve outcomes of nonsurgical curative treatments in hepatocellular carcinoma patients

(2016) Li-Li Wu et al.   MEDICINE

DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway

(2016) Alejandro Parrales et al.   NATURE CELL BIOLOGY

Clinicopathological and prognostic significance of Yes-associated protein expression in hepatocellular carcinoma and hepatic cholangiocarcinoma

(2016) Hao Wu et al.   TUMOR BIOLOGY

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

A randomised, double-blind, placebo-controlled multi-centre phase III trial of XELIRI/FOLFIRI plus simvastatin for patients with metastatic colorectal cancer

(2015) S H Lim et al.   BRITISH JOURNAL OF CANCER

Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis

(2015) Masatsugu Hiraki et al.   CHEMISTRY & BIOLOGY

Mevalonate Pathway Antagonist Suppresses Formation of Serous Tubal Intraepithelial Carcinoma and Ovarian Carcinoma in Mouse Models

(2015) Y. Kobayashi et al.   CLINICAL CANCER RESEARCH

YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins

(2015) Silvia Di Agostino et al.   EMBO REPORTS

Approaches of targeting Rho GTPases in cancer drug discovery

(2015) Yuan Lin et al.   Expert Opinion on Drug Discovery

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

(2015) Toshiro Moroishi et al.   GENES & DEVELOPMENT

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors

(2015) Patricia Marti et al.   HEPATOLOGY

The Hippo Pathway Effector YAP Regulates Motility, Invasion, and Castration-Resistant Growth of Prostate Cancer Cells

(2015) Lin Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

The Hippo transducer TAZ promotes epithelial to mesenchymal transition and cancer stem cell maintenance in oral cancer

(2015) Zhongwu Li et al.   Molecular Oncology

Cancer metastases: challenges and opportunities

(2015) Xiangming Guan   Acta Pharmaceutica Sinica B

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Hippo Signaling Mediates Proliferation, Invasiveness, and Metastatic Potential of Clear Cell Renal Cell Carcinoma

(2014) Ute Schütte et al.   Translational Oncology

Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53

(2013) Nan Bai et al.   CANCER BIOLOGY & THERAPY

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Suppression of interactions between prostate tumor cell-surface integrin and endothelial ICAM-1 by simvastatin inhibits micrometastasis

(2013) Belal AL-Husein et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Statin Use and Reduced Cancer-Related Mortality

(2012) Sune F. Nielsen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Simvastatin stimulates apoptosis in cholangiocarcinoma by inhibition of Rac1 activity

(2011) Timothy Miller et al.   DIGESTIVE AND LIVER DISEASE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Rac and Rho GTPases in cancer cell motility control

(2010) Matteo Parri et al.   Cell Communication and Signaling

Mapping proteolytic cancer cell-extracellular matrix interfaces

(2008) Katarina Wolf et al.   CLINICAL & EXPERIMENTAL METASTASIS