Inhibition of amyloid-induced toxicity by ergothioneine in a transgenic Caenorhabditis elegans model

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

(2019) Suman De et al.   Nature Communications

Ergothioneine - a diet-derived antioxidant with therapeutic potential

(2018) Barry Halliwell et al.   FEBS LETTERS

Distribution and accumulation of dietary ergothioneine and its metabolites in mouse tissues

(2018) Richard Ming Yi Tang et al.   Scientific Reports

Why has therapy development for dementia failed in the last two decades?

(2016) Serge Gauthier et al.   Alzheimers & Dementia

Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration?

(2016) Irwin K. Cheah et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ergothioneine, an adaptive antioxidant for the protection of injured tissues? A hypothesis

(2016) Barry Halliwell et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Benchmarking of protein carbonylation analysis in Caenorhabditis elegans : specific considerations and general advice

(2016) S. Pyr dit Ruys et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Safety Evaluation of a Nature-Identical l-Ergothioneine in Sprague Dawley Rats

(2016) Palma Ann Marone et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

The Rapid Exchange of Zinc2+ Enables Trace Levels to Profoundly Influence Amyloid-β Misfolding and Dominates Assembly Outcomes in Cu2+/Zn2+ Mixtures

(2016) Christian J. Matheou et al.   JOURNAL OF MOLECULAR BIOLOGY

Metabolomic profiling of brain from infants who died from Sudden Infant Death Syndrome reveals novel predictive biomarkers

(2016) S F Graham et al.   Journal of Perinatology

Liver ergothioneine accumulation in a guinea pig model of non-alcoholic fatty liver disease. A possible mechanism of defence?

(2015) Irwin K. Cheah et al.   FREE RADICAL RESEARCH

Identification of novel biomarkers for Parkinson's disease by metabolomic technologies

(2015) Taku Hatano et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Ergothioneine and melatonin attenuate oxidative stress and protect against learning and memory deficits in C57BL/6J mice treated with D-galactose

(2014) T.-Y. Song et al.   FREE RADICAL RESEARCH

Clioquinol promotes the degradation of metal-dependent amyloid-  (A ) oligomers to restore endocytosis and ameliorate A  toxicity

(2014) K. E. S. Matlack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

Knockout of a putative ergothioneine transporter inCaenorhabditis elegansdecreases lifespan and increases susceptibility to oxidative damage

(2013) I. K. Cheah et al.   FREE RADICAL RESEARCH

Copper enhances APP dimerization and promotes Aβ production

(2013) Yasuha Noda et al.   NEUROSCIENCE LETTERS

Cu2+ Affects Amyloid-β (1–42) Aggregation by Increasing Peptide-Peptide Binding Forces

(2013) Francis Hane et al.   PLoS One

Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression

(2012) D. Allan Butterfield et al.   ANTIOXIDANTS & REDOX SIGNALING

Ergothioneine protects against neuronal injury induced by β-amyloid in mice

(2012) Nae-Cherng Yang et al.   FOOD AND CHEMICAL TOXICOLOGY

Cysteine as a sustainable sulfur reagent for the protecting-group-free synthesis of sulfur-containing amino acids: biomimetic synthesis of l-ergothioneine in water

(2012) Irene Erdelmeier et al.   GREEN CHEMISTRY

Mitochondria and Cell Bioenergetics: Increasingly Recognized Components and a Possible Etiologic Cause of Alzheimer's Disease

(2011) Russell H. Swerdlow   ANTIOXIDANTS & REDOX SIGNALING

Ergothioneine; antioxidant potential, physiological function and role in disease

(2011) Irwin K. Cheah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Effect of Ergothioneine on Clastogenic Potential and Mutagenic Activity

(2011) Alexander G. Schauss et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Brain Oligomeric β-Amyloid but Not Total Amyloid Plaque Burden Correlates With Neuronal Loss and Astrocyte Inflammatory Response in Amyloid Precursor Protein/Tau Transgenic Mice

(2011) Bibiana DaRocha-Souto et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The effect of dichloroacetate on health- and lifespan in C. elegans

(2010) S. Schaffer et al.   BIOGERONTOLOGY

Ergothioneine Prevents Copper-Induced Oxidative Damage to DNA and Protein by Forming a Redox-Inactive Ergothioneine−Copper Complex

(2010) Ben-Zhan Zhu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Ergothioneine protects against neuronal injury induced by cisplatin both in vitro and in vivo

(2010) Tuzz-Ying Song et al.   FOOD AND CHEMICAL TOXICOLOGY

Modulation of palmitic acid-induced cell death by ergothioneine: Evidence of an anti-inflammatory action

(2009) Incoronata Laurenza et al.   BIOFACTORS

Ageing in nematodes: do antioxidants extend lifespan in Caenorhabditis elegans?

(2009) Pamela Boon Li Pun et al.   BIOGERONTOLOGY

The unusual amino acid L-ergothioneine is a physiologic cytoprotectant

(2009) B D Paul et al.   CELL DEATH AND DIFFERENTIATION

Deceptively simple but simply deceptive -Caenorhabditis eleganslifespan studies: Considerations for aging and antioxidant effects

(2009) Jan Gruber et al.   FEBS LETTERS

The Caenorhabditis elegans Aβ1–42Model of Alzheimer Disease Predominantly Expresses Aβ3–42

(2009) Gawain McColl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification

(2009) Alicia N Minniti et al.   Molecular Neurodegeneration