Article
Materials Science, Multidisciplinary
Xiaoning Shan, Sam Aspinall, Daulet B. Kaldybekov, Fhataheya Buang, Adrian C. Williams, Vitaliy V. Khutoryanskiy
Summary: The successful synthesis of methacrylated PEOZ was confirmed, and its temperature-responsive properties were found to be dependent on the degree of methacrylation. Three soluble MAPEOZ derivatives with different degrees of methacrylation showed no significant cytotoxicity in cell toxicity studies. A slug mucosal irritation assay demonstrated that PEOZ and MAPEOZ do not cause mucosal irritation, and the mucoadhesive properties of these polymers were enhanced by the presence of methacryloyl groups and residual amines. These poly(2-ethyl-2-oxazoline) derivatives show excellent potential as mucoadhesive materials for drug delivery via mucosal routes.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Simise S. Sikhondze, Pedzisai A. Makoni, Roderick B. Walker, Sandile M. M. Khamanga
Summary: In this study, a once-daily-dosed chitosan-coated metronidazole (MTZ)-loaded solid lipid nanoparticles (SLNs) for ocular delivery were developed to improve the residence time and release of the drug in the eye, which may reduce patient non-adherence.
Article
Biochemistry & Molecular Biology
Mariacristina Gagliardi, Sara Chiarugi, Chiara De Cesari, Giulia Di Gregorio, Alessandra Diodati, Laura Baroncelli, Marco Cecchini, Ilaria Tonazzini
Summary: The study presents a method to obtain stable and cytocompatible crosslinked chitosan nanoparticles for intranasal drug delivery. The nanoparticles showed a stable size and surface charge, and exhibited good cytocompatibility in vitro. This synthetic system has potential as a drug carrier for intranasal delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Adaeze L. Onugwu, Anthony A. Attama, Petra O. Nnamani, Sabastine O. Onugwu, Ebele B. Onuigbo, Vitaliy V. Khutoryanskiy
Summary: This study developed and evaluated solid lipid nanoparticles coated with poly(2-ethyl-2-oxazoline) and chitosan for ocular delivery of ciprofloxacin. The optimized formulation showed good particle size and encapsulation efficiency, and chitosan-coated solid lipid nanoparticles exhibited higher mucoadhesion and retention on corneal tissues compared to poly(2-ethyl-2-oxazoline) formulation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Ridhdhi S. Dave, Taylor C. Goostrey, Maya Ziolkowska, Sofia Czerny-Holownia, Todd Hoare, Heather Sheardown
Summary: There is a growing demand for effective treatments for ocular conditions, with topical administration being the preferred method despite its drawbacks. Nanoparticles with tunable mucoadhesion and/or mucopenetration show potential to overcome these drawbacks and improve ocular bioavailability, reduce toxicity, and increase ocular retention. Recent advances in developing nanocarriers with tunable mucoadhesion and mucopenetration for drug delivery to the eye are highlighted in the current review.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Renas Rzgar Jalal, Twana Mohammed M. Ways, Mahmoud H. Abu Elella, Diyar Ahmed Hassan, Vitaliy V. Khutoryanskiy
Summary: Mucoadhesive nanoparticles based on methacrylated chitosan (MeCHI) were designed and compared with unmodified chitosan nanoparticles for the delivery of ciprofloxacin. The MeCHI nanoparticles showed smaller particle size, lower polydispersity index, higher encapsulation efficiency, and sustained drug release compared to their chitosan counterpart. The mucoadhesion study also demonstrated that the ciprofloxacin-loaded MeCHI nanoparticles had better retention on the mucosal surface.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Beatriz Silva, Lidia M. Goncalves, Berta Sao Braz, Esmeralda Delgado
Summary: This study investigates the delivery of EPO beta to the eye through subconjunctival administration of chitosan-hyaluronic acid-EPO beta nanoparticles. The results show that these nanoparticles can efficiently deliver EPO beta into the retina without adverse effects. This nanoformulation could be a promising tool for treating retinopathies.
Article
Polymer Science
Semira Bener, Ewa Pavlova, Hynek Benes, Ondrej Sedlacek
Summary: Intelligent redox-responsive polymers have great potential in biomedical applications. This study successfully synthesized thioether-containing PAOx through a simple post-polymerization modification and demonstrated its oxidation-responsive behavior by self-assembling into micelles.
Article
Polymer Science
Dilshad Qureshi, Ayasharani Sahoo, Biswaranjan Mohanty, Arfat Anis, Viktoryia Kulikouskaya, Kseniya Hileuskaya, Vladimir Agabekov, Preetam Sarkar, Sirsendu Sekhar Ray, Samarendra Maji, Kunal Pal
Summary: This study developed novel blend films based on PVA and COS, with varying COS concentration impacting properties such as color, crystallinity, mechanical stability, and antimicrobial activity of the films.
Article
Chemistry, Applied
Mai Bay Stie, Heidi Oblom, Anders Christian Norgaard Hansen, Jette Jacobsen, Ioannis S. Chronakis, Jukka Rantanen, Hanne Morck Nielsen, Natalja Genina
Summary: The study designed a multi-layered nanofiber-on-foam-on-film (NFF) drug delivery system with mucoadhesive properties and saliva-repelling ability, which improved drug absorption and permeability through oral mucosa. This system has great potential for non-invasive drug administration.
CARBOHYDRATE POLYMERS
(2023)
Review
Polymer Science
Aleksandra Lusina, Tomasz Nazim, Michal Ceglowski
Summary: Poly(2-oxazoline)s are synthetic polymers that are obtained through cationic ring-opening polymerization of 2-oxazoline monomers. They have various advantageous properties, such as biocompatibility, stability, and high functionalization possibilities, making them widely used in biomedical applications. The development of stimuli-responsive poly(2-oxazoline)s is of great importance in personalized treatment and biomedical engineering, as they can respond to specific environmental stimuli. This review article highlights recent discoveries in this field by Polish scientists and compares them with findings reported by other renowned specialists.
Article
Pharmacology & Pharmacy
Roman Moiseev, Fraser Steele, Vitaliy V. Khutoryanskiy
Summary: As drug delivery to the eye has advanced, researchers have focused on finding better treatments for ocular diseases. This study evaluated different polyaphron formulations and found that the 3% polyquaternium 10-based formulation had the best corneal retention, while the 10% poloxamer 188 and 1% polyquaternium 10-based formulations were the most stable. Toxicological evaluations showed that all four formulations had good biocompatibility with ocular tissues. These drug delivery systems have great potential for ocular drug delivery.
Article
Pharmacology & Pharmacy
Nitjawan Sahatsapan, Theerasak Rojanarata, Tanasait Ngawhirunpat, Praneet Opanasopit, Prasopchai Patrojanasophon
Summary: This study synthesized dual-functional mucoadhesive nanoparticles for intravesical chemotherapy, demonstrating effective drug delivery and potent inhibitory effects against cancer cells, showing potential clinical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Peter J. Haddow, Marcelo A. da Silva, Daulet B. Kaldybekov, Cecile A. Dreiss, Ewelina Hoffman, Victoria Hutter, Vitaliy V. Khutoryanskiy, Stewart B. Kirton, Najet Mahmoudi, William J. McAuley, Michael T. Cook
Summary: Thermoreversible gels transitioning between liquid-like and solid-like states have enabled breakthroughs in novel healthcare technologies. This study synthesized ABA copolymers with varying molecular weights of PDEA and PEG blocks, revealing the necessity of high molecular weight PEG blocks for forming solid-like thermoreversible gels. Optimization led to a mucoadhesive, stable, and non-toxic thermoreversible gel with controlled release of hydrophobic drugs, showcasing high promise for healthcare applications.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Polymer Science
Muhammad Umar Aslam Khan, Zahida Yaqoob, Mohamed Nainar Mohamed Ansari, Saiful Izwan Abd Razak, Mohsin Ali Raza, Amna Sajjad, Sajjad Haider, Fauzi Mh Busra
Summary: Composite hydrogels of CS/PVA and GO/CS/PVA were successfully synthesized and analyzed using various techniques, showing good swelling and drug release properties. The study also revealed better antibacterial and cell viability behaviors of the composite materials, indicating their potential as biomaterials in biomedical applications.
Article
Pharmacology & Pharmacy
Laura E. Agibayeva, Daulet B. Kaldybekov, Natalia N. Porfiryeva, Venera R. Garipova, Rauash A. Mangazbayeva, Rouslan Moustafine, Irina I. Semina, Grigoriy A. Mun, Sarkyt E. Kudaibergenov, Vitaliy V. Khutoryanskiy
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Chemistry, Physical
Guzel K. Abilova, Daulet B. Kaldybekov, Galiya S. Irmukhametova, Diara S. Kazybayeva, Zhanar A. Iskakbayeva, Sarkyt E. Kudaibergenov, Vitaliy V. Khutoryanskiy
Article
Biochemistry & Molecular Biology
Peter J. Haddow, Marcelo A. da Silva, Daulet B. Kaldybekov, Cecile A. Dreiss, Ewelina Hoffman, Victoria Hutter, Vitaliy V. Khutoryanskiy, Stewart B. Kirton, Najet Mahmoudi, William J. McAuley, Michael T. Cook
Summary: Thermoreversible gels transitioning between liquid-like and solid-like states have enabled breakthroughs in novel healthcare technologies. This study synthesized ABA copolymers with varying molecular weights of PDEA and PEG blocks, revealing the necessity of high molecular weight PEG blocks for forming solid-like thermoreversible gels. Optimization led to a mucoadhesive, stable, and non-toxic thermoreversible gel with controlled release of hydrophobic drugs, showcasing high promise for healthcare applications.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Polymer Science
D. S. Kazybayeva, G. S. Irmukhametova, V. V. Khutoryanskiy
Summary: This review focuses on the synthesis of novel organic compounds and polymer materials using click chemistry concept, specifically highlighting thiol-ene reactions and their diverse applications in biocompatible materials, cell culture, block copolymer synthesis, degradable materials, and various functionalized systems.
POLYMER SCIENCE SERIES B
(2022)
Article
Materials Science, Multidisciplinary
Xiaoning Shan, Sam Aspinall, Daulet B. Kaldybekov, Fhataheya Buang, Adrian C. Williams, Vitaliy V. Khutoryanskiy
Summary: The successful synthesis of methacrylated PEOZ was confirmed, and its temperature-responsive properties were found to be dependent on the degree of methacrylation. Three soluble MAPEOZ derivatives with different degrees of methacrylation showed no significant cytotoxicity in cell toxicity studies. A slug mucosal irritation assay demonstrated that PEOZ and MAPEOZ do not cause mucosal irritation, and the mucoadhesive properties of these polymers were enhanced by the presence of methacryloyl groups and residual amines. These poly(2-ethyl-2-oxazoline) derivatives show excellent potential as mucoadhesive materials for drug delivery via mucosal routes.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Roman V. Moiseev, Daulet B. Kaldybekov, Sergey K. Filippov, Aurel Radulescu, Vitaliy V. Khutoryanskiy
Summary: Liposomes with different modifications were formulated and their physicochemical characteristics and retention on ex vivo eye tissues were evaluated. The maleimide-decorated liposomes showed the best retention performance on bovine conjunctiva compared to other liposomal formulations.
Article
Chemistry, Multidisciplinary
Emma E. Brotherton, Thomas J. Neal, Daulet B. Kaldybekov, Mark J. Smallridge, Vitaliy V. Khutoryanskiy, Steven P. Armes
Summary: A series of thermoresponsive diblock copolymer worm gels with adjustable aldehyde content were prepared using RAFT aqueous dispersion polymerization. The aldehyde-functional worm gels showed comparable mucoadhesion performance to chitosan, a widely regarded positive control. The optimum degree of aldehyde functionality was found to be around 30%.
Article
Metallurgy & Metallurgical Engineering
R. A. Shulen, D. S. Kazybayeva
Summary: This study focuses on the synthesis and characterization of a new type of gel through thiol-ene click polymerization. The properties of the gels were analyzed and correlated with the composition of the initial monomer mixture (IMM). The results showed that the physicochemical properties of the gels varied with the IMM composition, and the gels exhibited different elastic properties and crosslinking densities. Additionally, the gels displayed a certain degree of degradation in a hydrogen peroxide solution, making them potential candidates for targeted drug delivery systems with prolonged release.
KOMPLEKSNOE ISPOLZOVANIE MINERALNOGO SYRA
(2022)
Article
Metallurgy & Metallurgical Engineering
El-Sayed Negim, A. M. Konysbay, G. Irmukhametova, S. N. Kalugin
Summary: The grafting copolymers prepared using polypropylene glycol (PPG) and styrene (St) showed improved thermal stability with an increasing ratio of styrene, while the glass transition temperature (Tg) decreased with the increasing ratio of styrene.
KOMPLEKSNOE ISPOLZOVANIE MINERALNOGO SYRA
(2021)
Article
Polymer Science
Diara S. Kazybayeva, Galiya S. Irmukhametova, Vitaliy V. Khutoryanskiy
Summary: The structure and properties of polymeric degradable networks prepared using thiol-ene click reactions were studied, as well as their degradation in different media. Slow hydrolytic degradation was observed in phosphate buffer, while faster degradation was observed in hydrogen peroxide solutions.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Meeting Abstract
Chemistry, Multidisciplinary
Vitaliy Khutoryanskiy, Anastasiya Victorova, Rouslan Moustafine, Guzel Abilova, Daulet Kaldybekov, Galiya Irmukhametova, Twana Ways, Wing Man Lau, Edward Mansfield, Leire Ruiz-Rubio
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Polymer Science
Mustafa Kalay, Abidin Esidir, Mahmut Ruzi, N. Burak Kiremitler, Mustafa Serdar Onses
Summary: This study proposes stable and addressable polymer PUFs, utilizing a cross-linkable polymer system, which demonstrates high stochastic characteristics and low-cost production. The performance of the polymer features is evaluated through various analyses, and direct image authentication is achieved using feature matching algorithms.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Jingyu Jin, Guoqiang Lu, Jun Nie, Xiaoqun Zhu
Summary: Photopolymerization technology is limited in the fields of food packaging and biomedicine due to the high migration of small molecules from photoinitiators. In this study, a polymerizable 2-vinyl thioxanthone (ETX) was synthesized to improve the migration stability of photoinitiators. Macromolecular photoinitiators (PPI1, PPI2) were also prepared to further reduce migration. The results showed that the ETX/TEOA system had higher initiation performance and PPI2 displayed favorable initiation ability. Additionally, the migration of ETX, PPI1, and PPI2 in photocured film was significantly reduced. These low-migration photoinitiators have potential applications in the fields of food packaging and biological materials.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Weijie Li, Jun Nie, Yingying Zhao, Xiaoqun Zhu
Summary: This study focuses on the development of high-performance, low-migration photoinitiators. A polymerizable photoinitiator (VBP) was synthesized by introducing an ethylene group into benzophenone, and three different molecular weight single-component photoinitiators (PVBN1-3) were synthesized based on VBP. The results show that these new photoinitiators have stronger absorption ability compared to benzophenone and significantly reduce the migration of initiators and co-initiators, addressing the safety concerns caused by migration.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Seira Morimune-Moriya, Yuki Iwahashi, Mitsuru Nakamura, Daisuke Ogawa, Keiji Nakamura
Summary: This study investigates the effect of plasma treatment on carbon nanotubes (CNTs) and the structure/properties of polyimide (PI) nanocomposites with ultra-low content of CNTs. The results show that plasma treatment introduces isocyanate groups on the surface of CNTs and enhances the interfacial interaction between PI and treated CNTs. This leads to a significant improvement in the mechanical properties of the nanocomposites, with even a small addition of treated CNTs showing a substantial increase in Young's modulus, tensile strength and toughness.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Yuanlong Li, Chaojie Chen, Guoqing Cui, Li Liu, Chao Zhou, Guangfeng Wu
Summary: In this study, a novel ion-conducting hydrogel was fabricated using a straightforward approach. The hydrogel showed excellent tensile properties and high toughness due to physical interactions and covalent binding. Additionally, the introduction of hydroxyethyl cellulose and lithium chloride improved the biocompatibility, mechanical properties, electrical conductivity, and frost resistance of the hydrogel, demonstrating its potential for cold climate applications.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Dengwei Yan, Jinxian Yang, Xuejun Pan, Xiaozheng Duan, Lianwei Li, Mo Zhu
Summary: The influence of backbone length on grafting efficiency during the graft-onto reaction process was investigated. It was found that the polydispersity effect of backbone length does not affect the final grafting efficiency, indicating that the local dynamics of chain segments dominate the graft-onto process.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Zhaoyi Luo, Xianjie Pan, Fanqi Liu, Quanxi Yi, Yanning Zeng, Yunhua Chen, Chaoyang Wang
Summary: This study provides a method to prepare high-performance epoxy materials with good malleability and thermal stability. The materials have self-healing and welding capabilities, thanks to the addition of specific chemical bonds and network structures. They exhibit mechanical properties comparable to commercial epoxy resins and show great potential for sustainable industrial development.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Chaoji Xiong, Hao Wang, Lihua Deng, Kun Liang, Chunhua Wu, Wei Wu, Qian Chen
Summary: In this study, four polyamides were synthesized and their adsorption performances for Hg2+ in aqueous systems were investigated. The polyamides exhibited high adsorption capacities and excellent reusability, with the involvement of sulfur, nitrogen, and oxygen in the chemical adsorption process of Hg2+.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Siim Laanesoo, Olivier Bonjour, Rauno Sedrik, Iris Tamsalu, Patric Jannasch, Lauri Vares
Summary: The insertion of rigid aliphatic or aromatic building blocks in polymer structures is an effective way to synthesize high -Tg polymer materials. In this study, a series of isosorbide-2-aryl carboxylate-5-methacrylate monomers (ArIMAs) were synthesized by functionalizing isosorbide 5-methacrylate with various aromatic lignin-inspired esters. These monomers were polymerized to obtain high molecular-weight poly(aryl carboxylate isosorbide methacrylates) (PArIMAs). The resulting polymers showed high glass transition temperatures and thermal stability, making them suitable for use as high-performance plastics and coatings.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Yuqian Wu, Weijie Xu, Jianliang Li, Zhangfeng Zhong, Liqing Huang, Shengke Li, Huaping Tan
Summary: This study investigates the improvement of degradation and drug release characteristics of dynamic Schiff base-mediated natural polysaccharide hydrogels using tannic acid (TA), leading to enhanced stability and functionality.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Xi Zhang, Xiangli Kong, Xin Zhou, Yiyan Gao, Yibo Sun, Guanghui Gao, Wei Liu, Kai Shi
Summary: Conductive hydrogels have great development prospects in flexible strain sensors, but long-term direct contact with human skin can cause bacterial infection. A hydrogel with antibacterial, biocompatibility, and toughness was designed and manufactured using a freeze-thaw method. The hydrogel maintains tensile properties and fatigue resistance at low temperatures and is resistant to bacteria. Therefore, hydrogel sensors can be used to monitor human movements.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Wei Zhang, Jiangang Yu, Mingyang Wu, Rui Li, Anqiang Zhang, Yaling Lin
Summary: In this study, polyacrylamide containing quaternary ammonium salts (PAM-X) were synthesized and found to effectively inhibit soil-borne pathogenic fungi while maintaining the balance of microbial population in soil. PAM-X also showed low toxicity to earthworms and fish, providing a new method for the prevention and control of soil-borne fungal diseases.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Jiawen He, Haojie Yu, Li Wang, Jian Yang, Yanhui Zhang, Wenbing Huang, Chenguang Ouyang
Summary: This review discusses the use of polymeric hydrogels for atmospheric water harvesting (AWH), including the mechanism of water sorption, fabrication methods, and strategies for optimizing the structure of hydrogels. The extended applications of hygroscopic photothermal hydrogels, such as agricultural irrigation and dehumidification, are also explored. The challenges and prospects of using polymeric hydrogels for AWH are summarized.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Ying Du, Shuaishuai Lu, Yuanna Sun, Qingshan Li, Xinhai He
Summary: This study introduces a method to improve the performance of hydrogels by incorporating proline, resulting in hydrogels with excellent stretchability, high conductivity, and long-term stability. The hydrogel remains flexible and conductive even at ultra-low temperatures.
EUROPEAN POLYMER JOURNAL
(2024)
