Article
Materials Science, Multidisciplinary
Xiaoning Shan, Sam Aspinall, Daulet B. Kaldybekov, Fhataheya Buang, Adrian C. Williams, Vitaliy V. Khutoryanskiy
Summary: The successful synthesis of methacrylated PEOZ was confirmed, and its temperature-responsive properties were found to be dependent on the degree of methacrylation. Three soluble MAPEOZ derivatives with different degrees of methacrylation showed no significant cytotoxicity in cell toxicity studies. A slug mucosal irritation assay demonstrated that PEOZ and MAPEOZ do not cause mucosal irritation, and the mucoadhesive properties of these polymers were enhanced by the presence of methacryloyl groups and residual amines. These poly(2-ethyl-2-oxazoline) derivatives show excellent potential as mucoadhesive materials for drug delivery via mucosal routes.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Polymer Science
Janni Lavikainen, Moldir Dauletbekova, Gaukhar Toleutay, Maria Kaliva, Maria Chatzinikolaidou, Sarkyt E. Kudaibergenov, Andrey Tenkovtsev, Vitaliy V. Khutoryanskiy, Maria Vamvakaki, Vladimir Aseyev
Summary: Gellan gum (GG) was chemically modified with PEtOx chains to prepare graft copolymers for prolonged drug delivery on the eye surface. The synthesized copolymers showed enhanced diffusion coefficient but maintained high biocompatibility with increased viability and proliferation of cultured cells at various concentrations. The study suggests potential applications for these graft copolymers in ocular drug delivery systems.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Medicine, Research & Experimental
Dhruti Avlani, Avichal Kumar, H. N. Shivakumar
Summary: TDF-loaded bioadhesive chitosan microparticles (CM) were successfully developed using an emulsification internal gelation technique. These microparticles demonstrated high drug entrapment efficiency and sustained drug release. They were incorporated into dispersible tablets (DT-TCM) to create a promising novel drug delivery platform for pre-exposure prophylaxis against HIV.
MOLECULAR PHARMACEUTICS
(2023)
Article
Polymer Science
Sebastian Halupczok, Maria Pfister, Annemarie Ringhand, Corinna Fetsch, Alevtina Cubukova, Antje Appelt-Menzel, Robert Luxenhofer
Summary: The partial reduction of poly(2-ethyl-2-oxazoline) was investigated, and a series of polymers were synthesized using different reduction methods. The reduction degree can be controlled by reaction time or stoichiometry, impacting the materials properties significantly.
Article
Polymer Science
Aline-Sarah Glaive, Catherine Amiel, Gisele Volet
Summary: This study describes a biocompatible platform of double hydrophilic graft copolymers based on poly(2-alkyl-2-oxazoline), which can form stimuli-responsive self-assemblies. The copolymers showed self-assembly behavior in aqueous solution, forming spherical structures. In addition, the copolymers exhibited temperature-responsive behavior.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Muhammad Umar Aslam Khan, Zahida Yaqoob, Mohamed Nainar Mohamed Ansari, Saiful Izwan Abd Razak, Mohsin Ali Raza, Amna Sajjad, Sajjad Haider, Fauzi Mh Busra
Summary: Composite hydrogels of CS/PVA and GO/CS/PVA were successfully synthesized and analyzed using various techniques, showing good swelling and drug release properties. The study also revealed better antibacterial and cell viability behaviors of the composite materials, indicating their potential as biomaterials in biomedical applications.
Article
Polymer Science
Semira Bener, Ewa Pavlova, Hynek Benes, Ondrej Sedlacek
Summary: Intelligent redox-responsive polymers have great potential in biomedical applications. This study successfully synthesized thioether-containing PAOx through a simple post-polymerization modification and demonstrated its oxidation-responsive behavior by self-assembling into micelles.
Article
Polymer Science
David Pizzi, Ayaat M. Mahmoud, Tobias Klein, Joshua P. Morrow, James Humphries, Zachary H. Houston, Nicholas L. Fletcher, Craig A. Bell, Kristofer J. Thurecht, Kristian Kempe
Summary: PEtOx bottlebrushes, a type of biocompatible polymer, show great potential as therapeutic carriers due to their low fouling nature and good biocompatibility. Increasing the backbone or side-chain length of PEtOx bottlebrushes leads to decreased cellular association in vitro and longer blood circulation times in vivo. This insight may be beneficial for designing next-generation PEtOx bottlebrushes with customized profiles for specific applications.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Catia G. Alves, Rita Lima-Sousa, Bruna L. Melo, Paula Ferreira, Andre F. Moreira, Ilidio J. Correia, Duarte de Melo-Diogo
Summary: The authors developed a novel nanoparticle that can be triggered by laser light for anticancer therapy. In vitro assays showed that the nanoparticle effectively reduced the viability of cancer models when exposed to laser light, while no cytotoxicity was observed without laser light. This on-demand effect may help reduce side effects, and the nanoparticle also exhibited good stability for future translation.
Article
Nanoscience & Nanotechnology
Honglin Zhu, Tiangang Yang, Sunni Chen, Xinhao Wang, Jie He, Yangchao Luo
Summary: In this study, chitosan-based double-network antibacterial hydrogels with excellent mechanical and antibacterial properties were developed. The hydrogels exhibited high compression resistance and excellent shape recovery, and showed significant antibacterial efficacy against both Gram-positive and Gram-negative bacteria.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Article
Polymer Science
Michael Dirauf, Nicole Fritz, Michael Gottschaldt, Christine Weber, Ulrich S. Schubert
Summary: In this study, the incorporation of an amino group into a bifunctional initiator for cationic ring-opening polymerization was achieved through a two-step reaction, resulting in well-defined polymers with molar masses of about 2000 g/mol. Post-polymerization modification steps were successful, including deprotection of the phthalimide moiety to introduce a cyclooctyne group for subsequent strain-promoted alkyne-azide click reactions with a commonly used binding motif. Characterization using electrospray ionization mass spectrometry confirmed the success of all modification steps.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Polymer Science
Peter Cernoch, Alessandro Jager, Zulfiya Cernochova, Vladimir Sincari, Lindomar J. C. Albuquerque, Rafal Konefal, Ewa Pavlova, Fernando C. Giacomelli, Eliezer Jager
Summary: A novel amphiphilic block copolymer based on PMeOx and PDPA was synthesized using a two-step approach, and hydrodynamic flow focusing nanoprecipitation microfluidics was utilized to manufacture block copolymer self-assemblies of different morphologies.
Article
Polymer Science
Danelya N. Makhayeva, Sergey K. Filippov, Sanzhar S. Yestemes, Galiya S. Irmukhametova, Vitaliy V. Khutoryanskiy
Summary: The study found that poly(2-ethyl-2-oxazoline) has a greater ability to bind iodine compared to poly(N-vinylpyrrolidone), but the iodophors formed by these two polymers exhibit similar antimicrobial properties.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Helton Jose Wiggers, Pascale Chevallier, Francesco Copes, Fernanda Heloisa Simch, Felipe da Silva Veloso, Giovana Maria Genevro, Diego Mantovani
Summary: Natural polymer-based films, specifically chitosan films, have been extensively studied as coatings for biomedical applications due to their favorable biological and mechanical properties. In this study, chitosan films crosslinked with quercetin were used as controlled release systems for the antibiotic drug trimethoprim. The results show that quercetin increases the crosslinking degree of chitosan films in a dose-dependent manner, affecting the release kinetics of the loaded drug while maintaining its antibacterial effects. This work demonstrates the potential of quercetin-crosslinked chitosan films as antibiotic-releasing coatings for biomedical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Nils Luedecke, Marek Bekir, Stephan Eickelmann, Matthias Hartlieb, Helmut Schlaad
Summary: Inspired by mussel proteins, a platform for protein-repellent macromolecules based on poly(2-ethyl-2-oxazoline) carrying catechol and cationic functional groups was developed. The polymers with catechol units showed a strong tendency to form surface-bound layers on different substrates, while the ones with additional cationic units were able to form defined and durable polymer films. These coatings prevented the attachment of model proteins, offering a biomimetic approach to nonfouling surface coatings.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Danelya N. Makhayeva, Sergey K. Filippov, Sanzhar S. Yestemes, Galiya S. Irmukhametova, Vitaliy V. Khutoryanskiy
Summary: The study found that poly(2-ethyl-2-oxazoline) has a greater ability to bind iodine compared to poly(N-vinylpyrrolidone), but the iodophors formed by these two polymers exhibit similar antimicrobial properties.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Adaeze Linda Onugwu, Chinekwu Sherridan Nwagwu, Obinna Sabastine Onugwu, Adaeze Chidiebere Echezona, Chinazom Precious Agbo, Stella Amarachi Ihim, Prosper Emeh, Petra Obioma Nnamani, Anthony Amaechi Attama, Vitaliy V. Khutoryanskiy
Summary: Diseases affecting the anterior segment of the eye are a major cause of vision impairment and blindness worldwide. Drug delivery to the eye through the topical ocular route is challenging due to structural and physiological constraints. Nanotechnology-based drug delivery systems have been investigated as effective alternatives to conventional ocular delivery systems for treating anterior segment diseases. This review discusses different nanotechnology-based delivery systems and their prospects in clinical use.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Sam R. Aspinall, Vitaliy V. Khutoryanskiy
Summary: This study synthesized and tested a range of functionalized silica particles and found that the particles with modified surfaces can significantly improve the retention of oral care formulations on oral mucosal surfaces.
Article
Polymer Science
Fhataheya Buang, Afroditi Chatzifragkou, Mohd Cairul Iqbal Mohd Amin, Vitaliy V. V. Khutoryanskiy
Summary: Non-ionic hydroxyethylcellulose (HEC) was chemically modified with glycidyl methacrylate to enhance its mucoadhesive properties. The modification was confirmed by H-1 NMR and FTIR spectroscopy, and quantification of methacryloyl groups was done using HPLC. Toxicity studies showed no toxicological effects of the modified HEC. Mucoadhesive wafers developed from the modified HEC exhibited significantly better mucoadhesive properties compared to unmodified HEC.
Article
Pharmacology & Pharmacy
Nadezda E. Kashapova, Ruslan R. Kashapov, Albina Y. Ziganshina, Dmitry O. Nikitin, Irina I. Semina, Vadim V. Salnikov, Vitaliy V. Khutoryanskiy, Rouslan I. Moustafine, Lucia Y. Zakharova
Summary: A water-soluble form of haloperidol was obtained by coaggregation with calix[4]resorcinol to form vesicular nanoparticles. The nanoparticles showed mucoadhesive and thermosensitive properties, making them potentially effective drug delivery systems. In pharmacological studies, haloperidol formulated with calix[4]resorcinol exhibited a cataleptogenic effect in rats both when administered intranasally and intraperitoneally.
Article
Polymer Science
Regina R. Vildanova, Svetlana F. Petrova, Sergey V. Kolesov, Vitaliy V. Khutoryanskiy
Summary: Preparation of stable hydrogels using charge-complementary polyelectrolyte chains offers practical advantages over the use of organic crosslinking agents. This study utilizes natural polyelectrolytes-chitosan and pectin-with their biocompatibility and biodegradability. Different molecular weights of pectin are used to prepare hydrogels with varying rheological characteristics and swelling kinetics. These polyelectrolyte hydrogels can release the cytostatic drug cisplatin over an extended period, potentially improving the effectiveness of cancer treatment.
Article
Pharmacology & Pharmacy
Fhataheya Buang, Manfei Fu, Afroditi Chatzifragkou, Mohd Cairul Iqbal Mohd Amin, Vitaliy V. Khutoryanskiy
Summary: Hydroxyethylcellulose (HEC) is a water-soluble polymer with poor mucoadhesive properties. This study explores the modification of HEC by conjugation with maleimide groups to improve its mucoadhesive properties. The modified HEC exhibits superior mucoadhesive properties compared to unmodified HEC, forming a strong bond with mucin. The safety and efficacy of the newly synthesized polymer derivatives were also evaluated.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Aigerim Ayazbayeva, Vikram Baddam, Alexey Shakhvorostov, Iskander Gussenov, Vladimir Aseyev, Mubarak Yermaganbetov, Sarkyt Kudaibergenov
Summary: In this study, amphoteric nano- and microgels were prepared and their properties were investigated. The effect of monomer composition on the size and swelling capacity of the gels was studied, and the potential application of one microgel in oil recovery was tested.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Polymer Science
Iskander Gussenov, Alexey Shakhvorostov, Aigerim Ayazbayeva, Nargiz Gizatullina, Alexey Klivenko, Sarkyt Kudaibergenov
Summary: Preformed particle gels (PPGs) based on acrylamide, (3-acrylamidopropyl) trimethylammonium chloride, and 2-acrylamido-2-methyl-1-propanesulfonic acid sodium salt were synthesized. The swelling behavior of PPGs depending on various factors was studied, and it was found that adding clay mineral improved the mechanical properties and allowed control over the Young's modulus and swelling degree of the samples.
Article
Chemistry, Physical
Dina N. Akbayeva, Indira A. Smagulova, Kuralay S. Maksotova, Botagoz S. Bakirova, Gulnur S. Tatykhanova, Sarkyt E. Kudaibergenov
Summary: This study investigated the biocatalytic oxidation of ethanol to acetaldehyde using a catalase entrapped within a monolithic polyampholyte cryogel as the catalyst. The polyampholyte cryogels with varying amounts of catalase were synthesized in situ by cryo-polymerization of anionic monomer AMPS and cationic monomer APTAC. Under optimal conditions (temperature 10-20°C, pH 6.9-7.1, ethanol to hydrogen peroxide volume ratio 50:50), high yields of acetaldehyde from ethanol were achieved.
Article
Chemistry, Physical
Saul J. Hunter, Mahmoud H. Abu Elella, Edwin C. Johnson, Laura Taramova, Emma E. Brotherton, Steven P. Armes, Vitaliy V. Khutoryanskiy, Mark J. Smallridge
Summary: Spherical aldehyde-functionalized nanoparticles were prepared through aqueous emulsion polymerization, and when combined with oil droplets, formed nanoemulsions. The aldehyde-functionalized nanoparticles showed stronger adhesion to sheep nasal mucosal tissue due to the formation of imine bonds.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Zhiwei Huang, Roman V. Moiseev, Solomon S. Melides, Wooli Bae, Izabela Jurewicz, Vitaliy V. Khutoryanskiy, Joseph L. Keddie
Summary: This study evaluated the use of nanoparticles-stabilised Pickering emulsions for the confinement of organic components in ocular drug delivery. The results showed that these emulsions had good stability and mucoadhesive properties, and were non-toxic to tissues. These emulsions have distinct advantages for ocular drug delivery and could serve as a reference for future formulation design for drug delivery.
Article
Chemistry, Multidisciplinary
Sergey K. Filippov, Ramil Khusnutdinov, Anastasiia Murmiliuk, Wali Inam, Lucia Ya. Zakharova, Hongbo Zhang, Vitaliy V. Khutoryanskiy
Summary: This focus article provides a detailed analysis of transmission electron microscopy (TEM) and dynamic light scattering (DLS) as two common methods for studying nanoparticle sizes in pharmaceutics and drug delivery. The article highlights the importance of controlling nanoparticle size and shape in biomedical systems and discusses the discrepancies in size measurements obtained from TEM and DLS. The authors convincingly demonstrate that properly conducted experimental procedures and careful analysis of results can eliminate or reduce the mismatch between DLS and TEM data.
MATERIALS HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
A. Ye Ayazbayeva, A. Shakhvorostov, S. E. Kudaibergenov
Summary: Three nanogels with anionic, cationic, and amphoteric character were synthesized and their temperature and salt responsive properties were studied.
BULLETIN OF THE UNIVERSITY OF KARAGANDA-CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Emma E. Brotherton, Thomas J. Neal, Daulet B. Kaldybekov, Mark J. Smallridge, Vitaliy V. Khutoryanskiy, Steven P. Armes
Summary: A series of thermoresponsive diblock copolymer worm gels with adjustable aldehyde content were prepared using RAFT aqueous dispersion polymerization. The aldehyde-functional worm gels showed comparable mucoadhesion performance to chitosan, a widely regarded positive control. The optimum degree of aldehyde functionality was found to be around 30%.
