Article
Food Science & Technology
Kariyawasam Majuwana Gamage Menaka Menike Kariyawam, Na-Kyoung Lee, Hyun-Dong Paik
Summary: This study aimed to develop a functional synbiotic yoghurt enriched with L. brevis KU200019 and FOS, which showed high antioxidant and immunomodulatory activities after storage. The supplementation of probiotics or FOS did not have adverse effects and could be used to improve the health benefits and quality of dairy products.
Review
Pharmacology & Pharmacy
Yumin Wang, Shuang Wu, Qiang Li, Weihong Lang, Wenjing Li, Xiaodong Jiang, Zhirong Wan, Jichao Chen, Hongquan Wang
Summary: This review summarizes the recent updates and knowledge of the molecular mechanisms underlying the neuroprotective effects of epigallocatechin 3-gallate (EGCG) derived from green tea extract in Parkinson's disease (PD). The review highlights the pleiotropic effects of EGCG, including anti-apoptotic, anti-oxidative stress, anti-inflammatory, modulation of dopamine production, and inhibition of alpha-synuclein aggregation, which make it a promising neuroprotective compound for the treatment of PD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Cristian Parra-Sepulveda, Kimberly Sanchez-Alonzo, Joaquin Olivares-Munoz, Cristian Gutierrez-Zamorano, Carlos T. Smith, Romina Carvajal, Katia Saez-Carrillo, Carlos Gonzalez, Apolinaria Garcia-Cancino
Summary: This study shows that consuming the L. fermentum UCO-979C strain can significantly reduce H. pylori infection, with an efficacy of 92.6% in non-infected individuals.
Article
Neurosciences
Mizuho Uchino, Yukito Sashide, Mamoru Takeda
Summary: Local administration of (-)-epigallocatechin-3-gallate (EGCG), the main polyphenolic compound in green tea, can inhibit the excitability of nociceptive sensory neurons by inhibiting voltage-gated sodium channels and opening voltage-gated potassium channels. Thus, using EGCG as a local anesthetic may provide relief from trigeminal nociceptive pain without side effects.
Article
Food Science & Technology
Ajay Kumar, Shaik Abdul Hussain, Writdhama Prasad, Ashish Kumar Singh, R. R. B. Singh
Summary: The study found that adding HMP stabilizer to Aloe vera synbiotic lassi (ASL) can enhance pH and viscosity, reduce acidity and serum separation, and improve consistency and sensory attributes. Conversely, adding CMC increases whey syneresis, decreases viscosity, and negatively affects sensory attributes. Copper addition effectively reduces serum separation and increases oxidation, while probiotic count remains stable. Overall, both the stabilizers and copper contribute to the storage stability and quality of ASL.
Article
Plant Sciences
Narendra Vijay Tirpude, Anamika Sharma, Monika Kumari, Neha Bhardwaj
Summary: The study demonstrates that vitexin can alleviate allergic asthma through regulating oxidative stress, autophagy, and apoptosis. It shows protective effects in various aspects and has a potential therapeutic value.
Review
Immunology
Arbind Kumar, Aashish Sharma, Narendra Vijay Tirpude, Suresh Sharma, Yogendra S. Padwad, Sanjay Kumar
Summary: This article discusses the severity and risk factors of hypercytokinemia in COVID-19 patients, with a special emphasis on prospective immunomodulatory therapies. Timely administration of immunomodulatory drugs may help mitigate the severity of the disease, reduce hospital stay, and lower mortality rate.
INFLAMMOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Deepika Nag, Abhishek Goel, Yogendra Padwad, Dharam Singh
Summary: The study evaluated the probiotic potential of yeast PCH397 isolated from yak milk, showing its tolerance to GI tract conditions, strong cell surface hydrophobicity, and autoaggregation ability. PCH397 demonstrated beneficial effects on insulin sensitisation, anti-adipogenic properties, and anti-colon cancer potential, indicating its therapeutic value against obesity, T2D, and colon cancer.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Chemistry, Applied
Ranjana Sharma, Shiv Kumar, Smita Kapoor, Yogendra Padwad, Dinesh Kumar
Summary: A comprehensive chemical analysis of underutilized parts of Camellia sinensis was performed using NMR techniques, identifying and quantifying fifty-seven metabolites across the tissues. HPLCDAD analysis revealed differences in the levels of catechins, caffeine, and theanine among different parts of C. sinensis. Additionally, cytotoxicity studies showed anticancer potentials in tea tissues against colorectal cancer cell lines.
Article
Immunology
Narendra Vijay Tirpude, Anamika Sharma, Neha Bhardwaj
Summary: This study found that agnuside has a preventive effect on allergic asthma by suppressing inflammatory cell infiltration, congestion, fibrosis, airway remodeling, and alveolar collapse. Agnuside also reduces the expression of allergic inflammatory mediators and oxidative stress molecules, and modulates myeloid cell activation and Tregs in allergic asthma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jyoti Chhimwal, Abhishek Goel, Mahesh Sukapaka, Vikram Patial, Yogendra Padwad
Summary: Nonalcoholic fatty liver disease (NAFLD) is a growing global health concern, and alterations in cellular redox homeostasis and autophagy play a critical role in its progression. This study found that phloretin can effectively attenuate NAFLD progression by upregulating autophagy-mediated lipid breakdown and inhibiting oxidative damage, hepatic inflammation, and fibrosis.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Rohit Sharma, Ravi Kumar, Anamika Sharma, Abhishek Goel, Yogendra Padwad
Summary: Cellular senescence is a major hallmark of aging, and chronic consumption of green tea catechin epigallocatechin gallate (EGCG) can mitigate the progression of cellular senescence in adipose and intestinal tissues. EGCG attenuates DNA damage, inflammation, immunosenescence, and gut dysbiosis associated with aging, while promoting nutrient signaling mediators and preserving microbial diversity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Immunology
Anamika Sharma, Narendra Vijay Tirpude, Neha Bhardwaj, Dinesh Kumar, Yogendra Padwad
Summary: The present study investigated the anti-arthritic efficacy and molecular mechanism of BLFE and its phytoconstituents berberine and rutin. The findings showed that BLFE, rutin and berberine effectively reduced disease severity index, articular damage, immune cell influx, and pannus formation. They also regulated levels of various cytokines, enzymes, and signaling molecules involved in inflammation. These phytoconstituents exert their effects through the modulation of multiple molecular pathways.
INFLAMMOPHARMACOLOGY
(2022)
Article
Biology
Prateek Singh, Rajat Ujjainiya, Satyartha Prakash, Salwa Naushin, Viren Sardana, Nitin Bhatheja, Ajay Pratap Singh, Joydeb Barman, Kartik Kumar, Saurabh Gayali, Raju Khan, Birendra Singh Rawat, Karthik Bharadwaj Tallapaka, Mahesh Anumalla, Amit Lahiri, Susanta Kar, Vivek Bhosale, Mrigank Srivastava, Madhav Nilakanth Mugale, C. P. Pandey, Shaziya Khan, Shivani Katiyar, Desh Raj, Sharmeen Ishteyaque, Sonu Khanka, Ankita Rani, Promila, Jyotsna Sharma, Anuradha Seth, Mukul Dutta, Nishant Saurabh, Murugan Veerapandian, Ganesh Venkatachalam, Deepak Bansal, Dinesh Gupta, Prakash M. Halami, Muthukumar Serva Peddha, Ravindra P. Veeranna, Anirban Pal, Ranvijay Kumar Singh, Suresh Kumar Anandasadagopan, Parimala Karuppanan, Syed Nasar Rahman, Gopika Selvakumar, Subramanian Venkatesan, Malay Kumar Karmakar, Harish Kumar Sardana, Anamika Kothari, Devendra Singh Parihar, Anupma Thakur, Anas Saifi, Naman Gupta, Yogita Singh, Ritu Reddu, Rizul Gautam, Anuj Mishra, Avinash Mishra, Iranna Gogeri, Geethavani Rayasam, Yogendra Padwad, Vikram Patial, Vipin Hallan, Damanpreet Singh, Narendra Tirpude, Partha Chakrabarti, Sujay Krishna Maity, Dipyaman Ganguly, Ramakrishna Sistla, Narender Kumar Balthu, Kiran A. Kumar, Siva Ranjith, B. Vijay Kumar, Piyush Singh Jamwal, Anshu Wali, Sajad Ahmed, Rekha Chouhan, Sumit G. Gandhi, Nancy Sharma, Garima Rai, Faisal Irshad, Vijay Lakshmi Jamwal, Masroor Ahmad Paddar, Sameer Ullah Khan, Fayaz Malik, Debashish Ghosh, Ghanshyam Thakkar, S. K. Barik, Prabhanshu Tripathi, Yatendra Kumar Satija, Sneha Mohanty, Md Tauseef Khan, Umakanta Subudhi, Pradip Sen, Rashmi Kumar, Anshu Bhardwaj, Pawan Gupta, Deepak Sharma, Amit Tuli, Saumya Ray Chaudhuri, Srinivasan Krishnamurthi, L. Prakash, Ch Rao, B. N. Singh, Arvindkumar Chaurasiya, Meera Chaurasiya, Mayuri Bhadange, Bhagyashree Likhitkar, Sharada Mohite, Yogita Patil, Mahesh Kulkarni, Rakesh Joshi, Vaibhav Pandya, Sachin Mahajan, Amita Patil, Rachel Samson, Tejas Vare, Mahesh Dharne, Ashok Giri, Sachin Mahajan, Shilpa Paranjape, G. Narahari Sastry, Jatin Kalita, Tridip Phukan, Prasenjit Manna, Wahengbam Romi, Pankaj Bharali, Dibyajyoti Ozah, RaviKumar Sahu, Prachurjya Dutta, Moirangthem Goutam Singh, Gayatri Gogoi, Yasmin Begam Tapadar, Elapavalooru V. S. S. K. Babu, Rajeev K. Sukumaran, Aishwarya R. Nair, Anoop Puthiyamadam, Prajeesh Kooloth Valappil, Adrash Velayudhan Pillai Prasannakumari, Kalpana Chodankar, Samir Damare, Ved Varun Agrawal, Kumardeep Chaudhary, Anurag Agrawal, Shantanu Sengupta, Debasis Dash
Summary: Data science has played a crucial role in the COVID-19 pandemic response, and this study demonstrates how a statistical and machine learning approach can be used to discriminate between SARS-CoV-2 infection and immune response to a whole virion vaccine. By analyzing serial antibody data and incorporating an ensemble ML model, the researchers were able to accurately classify potential infections and validate their findings through neutralization assays. This study highlights the importance of real-world vaccine effectiveness assessments for whole virion vaccines.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Arbind Kumar, Aashish Sharma, Narendra Vijay Tirpude, Yogendra Padwad, Vipin Hallan, Sanjay Kumar
Summary: The SARS-CoV-2 outbreak has presented numerous challenges to the global healthcare and socioeconomic systems. Plant-derived immune adjuvants can enhance vaccine effectiveness and stimulate the necessary immune response to combat COVID-19.
PHARMACOLOGICAL REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Abhishek Goel, Yamini, Chitralekha Gusain, Bhanu Sharma, Rituraj Purohit, Pralay Das, Yogendra Padwad
Summary: Obesity and diabetes are major causes of death worldwide. Organic sulfone analogues have shown promise as insulin sensitizer and anti-adipogenic agents, but specific sulfone-derived anti-adipogenic agents are currently unavailable. In this study, different benzosuberene-alkyl sulfone (BSAS) analogues were synthesized and assessed for their binding to PPAR gamma and their anti-adipogenic potential. Among the tested compounds, BSAS-1 showed partial PPAR gamma agonist activity and effectively reduced adipogenesis. It also improved insulin sensitivity and glucose uptake in L6 myotubes. Our findings suggest that BSAS-1 has the potential to treat obesity and obesity-induced insulin resistance.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Cell Biology
Smita Kapoor, Yogendra S. Padwad
Summary: Ulcerative colitis is an inflammatory bowel disease associated with an increased risk of colorectal cancer. This study investigated the anti-inflammatory potential of phloretin, a compound found in fruits like apple, pear, and strawberries, using an in vitro gut inflammation model. The findings suggest that phloretin has anti-inflammatory effects and may be beneficial in preventing colitis and colorectal cancer.
CELLULAR IMMUNOLOGY
(2023)
Article
Materials Science, Biomaterials
Jyoti Chhimwal, Rakesh Kumar Dhritlahre, Prince Anand, Vikram Ruchika, Vikram Patial, Ankit Saneja, Yogendra S. Padwad
Summary: The amorphous solid dispersion of phloretin (Ph-SD) showed potential therapeutic effects in the treatment of non-alcoholic fatty liver disease (NAFLD). The formulation improved the solubility and oral bioavailability of phloretin and reduced fibrotic changes in the liver tissues by blocking the mTOR/SREBP-1c pathway.
BIOMATERIALS ADVANCES
(2023)
