Divergent Dynamics and Functions of ERK MAP Kinase Signaling in Development, Homeostasis and Cancer: Lessons from Fluorescent Bioimaging

TNFRSF19 inhibits TGFβ signaling through interaction with TGFβ receptor type I to promote tumorigenesis

(2018) Chengcheng Deng et al.   CANCER RESEARCH

A Switch-like Activation Relay of EGFR-ERK Signaling Regulates a Wave of Cellular Contractility for Epithelial Invagination

(2018) Yosuke Ogura et al.   DEVELOPMENTAL CELL

Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine

(2018) Yu Muta et al.   Nature Communications

Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway

(2018) L. J. Bugaj et al.   SCIENCE

ERK Activity Dynamics during Zebrafish Embryonic Development

(2018) Kah-Loon Wong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

EGFL6 promotes breast cancer by simultaneously enhancing cancer cell metastasis and stimulating tumor angiogenesis

(2018) Jingnan An et al.   ONCOGENE

Live-cell imaging of cell signaling using genetically encoded fluorescent reporters

(2017) Qiang Ni et al.   FEBS Journal

Antagonistic Interactions between Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and Retinoic Acid Receptor Signaling in Colorectal Cancer Cells

(2017) Masamichi Imajo et al.   MOLECULAR AND CELLULAR BIOLOGY

A Novel Signaling Complex between TROY and EGFR Mediates Glioblastoma Cell Invasion

(2017) Zonghui Ding et al.   MOLECULAR CANCER RESEARCH

Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control

(2017) Maxwell Z. Wilson et al.   MOLECULAR CELL

Spatial and Temporal Regulation of Receptor Tyrosine Kinase Activation and Intracellular Signal Transduction

(2016) John J.M. Bergeron et al.   Annual Review of Biochemistry

EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH + Ovarian Cancer Cells

(2016) Shoumei Bai et al.   CANCER RESEARCH

Negative feedback regulation of the ERK1/2 MAPK pathway

(2016) David Lake et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanisms of resistance to anti-EGFR therapy in colorectal cancer

(2016) Ben Zhao et al.   Oncotarget

Abstract 118: EGFL6, a potential novel ligand of EGFR, play roles in Nasopharyngeal cacinoma metastasis through establishing invasive and long-distant metastatic niche by paracrine and autocrine

(2015) Jinna Chen et al.   CANCER RESEARCH

Receptor Level Mechanisms Are Required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) Activity Pulses

(2015) Breanne Sparta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Spies for Bioimaging—Fluorescent Protein-Based Probes

(2015) Atsushi Miyawaki et al.   MOLECULAR CELL

Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin

(2015) Toru Hiratsuka et al.   eLife

High-Sensitivity Measurements of Multiple Kinase Activities in Live Single Cells

(2014) Sergi Regot et al.   CELL

In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines

(2014) Rei Mizuno et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

Fluorescence resonance energy transfer imaging of cell signaling fromin vitrotoin vivo: Basis of biosensor construction, live imaging, and image processing

(2013) Kazuhiro Aoki et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

TROY (TNFRSF19) Promotes Glioblastoma Survival Signaling and Therapeutic Resistance

(2013) Joseph C. Loftus et al.   MOLECULAR CANCER RESEARCH

Stochastic ERK Activation Induced by Noise and Cell-to-Cell Propagation Regulates Cell Density-Dependent Proliferation

(2013) Kazuhiro Aoki et al.   MOLECULAR CELL

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

(2012) Anne E. Powell et al.   CELL

Live Imaging of Protein Kinase Activities in Transgenic Mice Expressing FRET Biosensors

(2012) Yuji Kamioka et al.   CELL STRUCTURE AND FUNCTION

Expression of LRIG1 and LRIG3 correlates with human papillomavirus status and patient survival in cervical adenocarcinoma

(2012) SUSANNE MULLER et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals

(2012) John G. Albeck et al.   MOLECULAR CELL

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

(2012) Vivian W. Y. Wong et al.   NATURE CELL BIOLOGY

Development of an optimized backbone of FRET biosensors for kinases and GTPases

(2011) Naoki Komatsu et al.   MOLECULAR BIOLOGY OF THE CELL

Feedback regulation of EGFR signalling: decision making by early and delayed loops

(2011) Roi Avraham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TROY (TNFRSF19) Is Overexpressed in Advanced Glial Tumors and Promotes Glioblastoma Cell Invasion via Pyk2-Rac1 Signaling

(2010) V. M. Paulino et al.   MOLECULAR CANCER RESEARCH

Inhibition of LRIG3 gene expression via RNA interference modulates the proliferation, cell cycle, cell apoptosis, adhesion and invasion of glioblastoma cell (GL15)

(2009) Mingjun Cai et al.   CANCER LETTERS

Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning

(2009) Hiroshi Hanafusa et al.   NATURE CELL BIOLOGY

A genetically encoded fluorescent sensor of ERK activity

(2008) C. D. Harvey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA