Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway
出版年份 2018 全文链接
标题
Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway
作者
关键词
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出版物
SCIENCE
Volume 361, Issue 6405, Pages eaao3048
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2018-08-31
DOI
10.1126/science.aao3048
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- An immediate–late gene expression module decodes ERK signal duration
- (2017) Florian Uhlitz et al. Molecular Systems Biology
- MAPK kinase signalling dynamics regulate cell fate decisions and drug resistance
- (2016) Nora Rauch et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Interrogating cellular perception and decision making with optogenetic tools
- (2016) Lukasz J. Bugaj et al. JOURNAL OF CELL BIOLOGY
- Schedule-dependent interaction between anticancer treatments
- (2016) Sheng-hong Chen et al. SCIENCE
- BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition
- (2015) Zhan Yao et al. CANCER CELL
- Noise Facilitates Transcriptional Control under Dynamic Inputs
- (2015) Ryan A. Kellogg et al. CELL
- Receptor Level Mechanisms Are Required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) Activity Pulses
- (2015) Breanne Sparta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RAF inhibitors that evade paradoxical MAPK pathway activation
- (2015) Chao Zhang et al. NATURE
- Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin
- (2015) Toru Hiratsuka et al. eLife
- Vemurafenib in patients with BRAFV600 mutated metastatic melanoma: an open-label, multicentre, safety study
- (2014) James Larkin et al. LANCET ONCOLOGY
- Light-Mediated Kinetic Control Reveals the Temporal Effect of the Raf/MEK/ERK Pathway in PC12 Cell Neurite Outgrowth
- (2014) Kai Zhang et al. PLoS One
- Accurate information transmission through dynamic biochemical signaling networks
- (2014) J. Selimkhanov et al. SCIENCE
- Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module
- (2013) Jared E. Toettcher et al. CELL
- The Dynamics of Signaling as a Pharmacological Target
- (2013) Marcelo Behar et al. CELL
- Encoding and Decoding Cellular Information through Signaling Dynamics
- (2013) Jeremy E. Purvis et al. CELL
- Stochastic ERK Activation Induced by Noise and Cell-to-Cell Propagation Regulates Cell Density-Dependent Proliferation
- (2013) Kazuhiro Aoki et al. MOLECULAR CELL
- Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks
- (2012) Michael J. Lee et al. CELL
- Raf Inhibitors Target Ras Spatiotemporal Dynamics
- (2012) Kwang-jin Cho et al. CURRENT BIOLOGY
- Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals
- (2012) John G. Albeck et al. MOLECULAR CELL
- RASMutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
- (2012) Fei Su et al. NEW ENGLAND JOURNAL OF MEDICINE
- p53 Dynamics Control Cell Fate
- (2012) J. E. Purvis et al. SCIENCE
- Light-based feedback for controlling intracellular signaling dynamics
- (2011) Jared E Toettcher et al. NATURE METHODS
- Signal-dependent dynamics of transcription factor translocation controls gene expression
- (2011) Nan Hao et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
- (2011) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
- (2010) Sonja J. Heidorn et al. CELL
- RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
- (2010) Poulikos I. Poulikakos et al. NATURE
- RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
- (2010) Georgia Hatzivassiliou et al. NATURE
- Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
- (2010) Gideon Bollag et al. NATURE
- Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
- (2010) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- Impact of Feedback Phosphorylation and Raf Heterodimerization on Normal and Mutant B-Raf Signaling
- (2009) D. A. Ritt et al. MOLECULAR AND CELLULAR BIOLOGY
- Dynamics and Variability of ERK2 Response to EGF in Individual Living Cells
- (2009) Cellina Cohen-Saidon et al. MOLECULAR CELL
- A dimerization-dependent mechanism drives RAF catalytic activation
- (2009) Thanashan Rajakulendran et al. NATURE
- Pulsatile Stimulation Determines Timing and Specificity of NF- B-Dependent Transcription
- (2009) L. Ashall et al. SCIENCE
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