The Autism and Angelman Syndrome Protein Ube3A/E6AP: The Gene, E3 Ligase Ubiquitination Targets and Neurobiological Functions

UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

(2018) Jiandong Sun et al.   eLife

Adult Ube3a Gene Reinstatement Restores the Electrophysiological Deficits of Prefrontal Cortex Layer 5 Neurons in a Mouse Model of Angelman Syndrome

(2018) Diana C. Rotaru et al.   JOURNAL OF NEUROSCIENCE

Ube3a reinstatement mitigates epileptogenesis in Angelman syndrome model mice

(2018) Bin Gu et al.   JOURNAL OF CLINICAL INVESTIGATION

The Autism Protein Ube3A/E6AP Remodels Neuronal Dendritic Arborization via Caspase-Dependent Microtubule Destabilization

(2017) Natasha Khatri et al.   JOURNAL OF NEUROSCIENCE

Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1

(2017) Vaishnav Krishnan et al.   NATURE

Fundamental Elements in Autism: From Neurogenesis and Neurite Growth to Synaptic Plasticity

(2017) James Gilbert et al.   Frontiers in Cellular Neuroscience

Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency mice

(2017) Heather A. Born et al.   Scientific Reports

GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility

(2016) Matthew C. Judson et al.   NEURON

Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation

(2016) Janet Berrios et al.   Nature Communications

Angelman syndrome-derived neurons display late onset of paternal UBE3A silencing

(2016) Jana Stanurova et al.   Scientific Reports

The Emerging Picture of Autism Spectrum Disorder: Genetics and Pathology

(2015) Jason A. Chen et al.   Annual Review of Pathology-Mechanisms of Disease

An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A

(2015) Jason J. Yi et al.   CELL

Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model

(2015) Sara Silva-Santos et al.   JOURNAL OF CLINICAL INVESTIGATION

A coding-independent function of an alternative Ube3a transcript during neuronal development

(2015) Jeremy Valluy et al.   NATURE NEUROSCIENCE

Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders

(2015) Sacha B. Nelson et al.   NEURON

Seizure-like activity in a juvenile Angelman syndrome mouse model is attenuated by reducingArcexpression

(2015) Caleigh Mandel-Brehm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UBE3A Regulates Synaptic Plasticity and Learning and Memory by Controlling SK2 Channel Endocytosis

(2015) Jiandong Sun et al.   Cell Reports

Toward a Broader View of Ube3a in a Mouse Model of Angelman Syndrome: Expression in Brain, Spinal Cord, Sciatic Nerve and Glial Cells

(2015) Mark D. Grier et al.   PLoS One

Natural Neural Projection Dynamics Underlying Social Behavior

(2014) Lisa A. Gunaydin et al.   CELL

Activity-dependent changes in MAPK activation in the Angelman Syndrome mouse model

(2014) I. Filonova et al.   LEARNING & MEMORY

Allelic specificity of Ube3a Expression In The Mouse Brain During Postnatal Development

(2013) Matthew C. Judson et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The Angelman Syndrome Protein Ube3a/E6AP Is Required for Golgi Acidification and Surface Protein Sialylation

(2013) K. H. Condon et al.   JOURNAL OF NEUROSCIENCE

The Angelman Syndrome Protein Ube3a Is Required for Polarized Dendrite Morphogenesis in Pyramidal Neurons

(2013) S. Miao et al.   JOURNAL OF NEUROSCIENCE

Role of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein Arc

(2013) S. Kuhnle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Truncation of Ube3a-ATS Unsilences Paternal Ube3a and Ameliorates Behavioral Defects in the Angelman Syndrome Mouse Model

(2013) Linyan Meng et al.   PLoS Genetics

Pathway-specific dopaminergic deficits in a mouse model of Angelman syndrome

(2012) Thorfinn T. Riday et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of CaMKII action in long-term potentiation

(2012) John Lisman et al.   NATURE REVIEWS NEUROSCIENCE

Maternal Loss of Ube3a Produces an Excitatory/Inhibitory Imbalance through Neuron Type-Specific Synaptic Defects

(2012) Michael L. Wallace et al.   NEURON

Decreased Tonic Inhibition in Cerebellar Granule Cells Causes Motor Dysfunction in a Mouse Model of Angelman Syndrome

(2012) K. Egawa et al.   Science Translational Medicine

Small-Conductance Ca2+-Activated K+ Channels: Form and Function

(2011) John P. Adelman et al.   Annual Review of Physiology

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

(2011) Hsien-Sung Huang et al.   NATURE

Increased Gene Dosage of Ube3a Results in Autism Traits and Decreased Glutamate Synaptic Transmission in Mice

(2011) S. E. P. Smith et al.   Science Translational Medicine

Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes

(2011) Angela M. Mabb et al.   TRENDS IN NEUROSCIENCES

EphB-Mediated Degradation of the RhoA GEF Ephexin5 Relieves a Developmental Brake on Excitatory Synapse Formation

(2010) Seth S. Margolis et al.   CELL

The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc

(2010) Paul L. Greer et al.   CELL

‘Puppet’ Children A Report on Three Cases

(2010) Harry Angelman   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Functional impact of global rare copy number variation in autism spectrum disorders

(2010) Dalila Pinto et al.   NATURE

Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome

(2010) Richard M. Gustin et al.   NEUROBIOLOGY OF DISEASE

Genomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene Ube3a

(2010) M. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain

(2009) Frederico A.C. Azevedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Psychiatric Disorders in Children With Autism Spectrum Disorders: Prevalence, Comorbidity, and Associated Factors in a Population-Derived Sample

(2009) Emily Simonoff et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Autism

(2009) Susan E Levy et al.   LANCET

Molecular regulation of neuronal migration during neocortical development

(2009) Zhen Huang   MOLECULAR AND CELLULAR NEUROSCIENCE

Ube3a is required for experience-dependent maturation of the neocortex

(2009) Koji Yashiro et al.   NATURE NEUROSCIENCE

Autism and Brain Development

(2008) Christopher A. Walsh et al.   CELL

Think locally: control of ubiquitin-dependent protein degradation in neurons

(2008) Alexandra Segref et al.   EMBO REPORTS

The Drosophila homologue of the Angelman syndrome ubiquitin ligase regulates the formation of terminal dendritic branches

(2008) Y. Lu et al.   HUMAN MOLECULAR GENETICS

SK2 channel plasticity contributes to LTP at Schaffer collateral–CA1 synapses

(2008) Mike T Lin et al.   NATURE NEUROSCIENCE

Bidirectional modulation of synaptic functions by Eph/ephrin signaling

(2008) Rüdiger Klein   NATURE NEUROSCIENCE

The comorbidity of autism with the genomic disorders of chromosome 15q11.2-q13

(2008) Amber Hogart et al.   NEUROBIOLOGY OF DISEASE

Autism: Definition, Neurobiology, Screening, Diagnosis

(2008) Isabelle Rapin et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Identifying Autism Loci and Genes by Tracing Recent Shared Ancestry

(2008) E. M. Morrow et al.   SCIENCE