Article
Pharmacology & Pharmacy
Zheng Zhou, Keying Li, Yongchao Chu, Chao Li, Tongyu Zhang, Peixin Liu, Tao Sun, Chen Jiang
Summary: Epilepsy is a neurological disorder characterized by abnormal synchronized discharging of neurons. It is also influenced by non-neuronal elements in the altered microenvironment. Current anti-epileptic drugs mainly target neuronal circuits, but are often insufficient. Therefore, there is a need for comprehensive strategies in medication to address over-exciting neurons, activated glial cells, oxidative stress, and chronic inflammation.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Environmental Sciences
Madhuri Grover, Tapan Behl, Simona Bungau, Lotfi Aleya
Summary: This study focuses on investigating the anti-inflammatory properties of vetiver, revealing that its plant extract can stimulate the antioxidant enzyme system network, reduce oxidative stress, exhibit antimicrobial activity, and have a CNS depressant effect, showing potential benefits in treating inflammation-related disorders.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Chen Chen, Xiao Yang, Shu-jing Li, Chao Zhang, Yu-ning Ma, Yu-xia Ma, Peng Gao, Shu-zhong Gao, Xiao-jun Huang
Summary: The TATA supramolecular hydrogel, synthesized through ring-opening polymerization, possesses self-healing and injectable properties, and has been successfully used for skin wound healing and burn wound infection treatment. XPS confirmed successful intermolecular crosslinking, showcasing its potential as a surgical antibacterial bioadhesive.
Article
Chemistry, Multidisciplinary
Man Fan, Le Jia, Minghui Pang, Xiangliang Yang, Yajiang Yang, Samir Kamel Elyzayati, Yonggui Liao, Hong Wang, Yanhong Zhu, Qin Wang
Summary: The study presents a novel injectable adhesive hydrogel loaded with MnO2 nanoparticles that induce immunogenic cell death and release tumor protein antigens to stimulate the immune response, effectively inhibiting tumor growth.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Chou-Yuan Ko, Po-Chang Shih, Po-Wei Huang, Yi-Hsin Lee, Yen-Fu Chen, Ming-Hong Tai, Chi-Hao Liu, Zhi-Hong Wen, Hsiao-Mei Kuo
Summary: Sinularin was found to effectively inhibit the growth of hepatocellular carcinoma SK-HEP-1 cells at a concentration of 10 μM, inducing DNA fragmentation and apoptosis, as well as affecting cell migration and colony formation. Additionally, it altered the expression levels of various proteins related to cell signaling and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Shaoquan Bian, Liuzhi Hao, Xin Qiu, Jun Wu, Hao Chang, Guan-Ming Kuang, Sheng Zhang, Xiaohua Hu, Yakang Dai, Zhiyong Zhou, Fangli Huang, Chun Liu, Xuenong Zou, Wenguang Liu, Willima W. Lu, Haobo Pan, Xiaoli Zhao
Summary: The study successfully developed an injectable hydrogel with rapid adhesion and anti-swelling properties. The hydrogel can quickly adhere to wet tissues and maintains its volume stability during degradation. It demonstrates fast hemostasis in various bleeding models and has good biocompatibility with low risk of hemolysis.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Medicinal
Qifang Chen, Peilin Gu, Xuemei Liu, Shaohua Hu, Hong Zheng, Ting Liu, Chongyi Li
Summary: Nanoparticle-based drug delivery systems, specifically gold nanoparticles containing resveratrol, have been designed to delay cataracts and mitigate oxidative stress damage in lens epithelial cells. These nanosystems exhibit the ability to reduce cellular senescence and postpone cataract development through the activation of the Sirt1/Nrf2 signaling pathway.
Article
Plant Sciences
Liping Chen, Di Feng, Yafang Qian, Xiao Cheng, Huizhu Song, Yifan Qian, Xu Zhang, Yali Wu, Huawei Lv, Qi Liu, Gang Cheng, Bo Yang, Mancang Gu
Summary: Valtrate exhibits anti-cancer activity against pancreatic cancer cells by directly targeting Stat3 through a covalent linkage to inhibit Stat3 activity, leading to apoptosis and cell cycle arrest.
Article
Biochemistry & Molecular Biology
Masaya Sano, Daisuke Akagi, Mitsuru Naito, Katsuyuki Hoshina, Kanjiro Miyata, Kazunori Kataoka, Soichiro Ishihara
Summary: This study used nanomedicine to deliver miR146a-5p in a rat carotid artery balloon injury model and found that it can inhibit inflammatory response and vascular smooth muscle cell migration, as well as reduce reactive oxygen species production and proinflammatory cytokine gene expression. In a rat model, miR146a-5p attenuated NIH and vessel remodeling by reducing proinflammatory cytokine gene expression in injured arteries and monocyte/macrophage infiltration into the vascular wall.
Article
Pharmacology & Pharmacy
Sara Gea-Botella, Bryan Moreno-Chamba, Laura de la Casa, Julio Salazar-Bermeo, Nuria Marti, Maria Concepcion Martinez-Madrid, Manuel Valero, Domingo Saura
Summary: Persimmon fruits are a rich source of carotenoids, which have protective effects against UV radiation. An acetone extract rich in carotenoids derived from persimmon byproducts was found to have photoprotective and regenerative effects on UV-irradiated HaCaT cells, showing potential for use in skincare products.
Article
Engineering, Biomedical
Pijush Giri, Devendra Verma
Summary: Post-surgical tissue adhesions are a serious clinical concern, but a novel dual crosslinking hydrogel has been developed using albumin. This hydrogel has preserved its microstructure and demonstrated excellent mechanical strength, self-healing characteristics, and quick gelling time. With its promising features, the dual crosslinked injectable hydrogel has potential applications in biomedicine for preventing post-surgical adhesions.
BIOMEDICAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Swathi Balaji, Walker D. Short, Benjamin W. Padon, Jorge A. Belgodere, Sarah E. Jimenez, Naresh T. Deoli, Anna C. Guidry, Justin C. Green, Tanuj J. Prajapati, Fayiz Farouk, Aditya Kaul, Dongwan Son, Olivia S. Jung, Carlos E. Astete, Myungwoong Kim, Jangwook P. Jung
Summary: In this study, functionalized lignin was used to provide antioxidation to the extracellular microenvironments of wounds and deliver oxygen for enhanced vascularization and healing. Lignin composites with oxygen-generating nanoparticles were found to release a significant amount of oxygen per day for at least 7 days. The in situ formation of these composites enhanced tissue granulation, blood vessel formation, and fibroblast infiltration, and remodeled collagen architecture after 28 days.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Tullia Maraldi, Cristina Angeloni, Cecilia Prata, Silvana Hrelia
Summary: This review highlights the role of NOX-derived ROS in stem cell biology and functions, focusing on the positive and negative effects triggered by the activity of different NOX isoforms. Recent findings on downstream molecular targets of NOX-ROS signaling that can modulate stem cell homeostasis and lineage commitment are discussed, along with implications in ex vivo expansion and in vivo engraftment, function, and longevity. The pivotal role of NOX as a regulator of several stem cell populations is underscored, and further studies on the effects of pharmacological modulation of NOX in human stem cells are deemed imperative.
Article
Engineering, Biomedical
Chen Shi, Ying Zhang, Guanfu Wu, Zhangyu Zhu, Haiping Zheng, Ximeng Sun, Yongyuan Heng, Shaowei Pan, Haonan Xiu, Jing Zhang, Zhaowei Yin, Ziyi Yu, Bin Liang
Summary: This study developed a reactive oxygen species (ROS)-responsive multifunctional injectable hydrogel for diabetic wound healing. The hydrogel effectively loaded and released curcumin liposomes and silver nanoparticles (AgNPs), promoting wound healing through ROS scavenging, bactericidal activity, anti-inflammatory effects, and angiogenesis. The hydrogel demonstrated favorable biocompatibility, degradability, and injectivity.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Md. Ataur Rahman, Kazi Rejvee Ahmed, Farzana Haque, Moon Nyeo Park, Bonglee Kim
Summary: Autophagy is a fundamental process for maintaining cellular homeostasis and survival. It involves the degradation of cellular components to generate energy and maintain stability. It has been found to play a crucial role in disease progression and maintaining redox equilibrium.
Article
Chemistry, Multidisciplinary
Kazuki Miyano, Horacio Cabral, Yutaka Miura, Yu Matsumoto, Yuki Mochida, Hiroaki Kinoh, Caname Iwata, Osamu Nagano, Hideyuki Saya, Nobuhiro Nishiyama, Kazunori Kataoka, Tatsuya Yamasoba
JOURNAL OF CONTROLLED RELEASE
(2017)
Article
Clinical Neurology
Teru Kamogashira, Shinichi Iwasaki, Akinori Kashio, Akinobu Kakigi, Shotaro Karino, Yu Matsumoto, Tatsuya Yamasoba
OTOLOGY & NEUROTOLOGY
(2017)
Article
Multidisciplinary Sciences
Y. Anraku, H. Kuwahara, Y. Fukusato, A. Mizoguchi, T. Ishii, K. Nitta, Y. Matsumoto, K. Toh, K. Miyata, S. Uchida, K. Nishina, K. Osada, K. Itaka, N. Nishiyama, H. Mizusawa, T. Yamasoba, T. Yokota, K. Kataoka
NATURE COMMUNICATIONS
(2017)
Article
Medicine, Research & Experimental
Yuji Kiyama, Yayoi S. Kikkawa, Makoto Kinoshita, Yu Matsumoto, Kenji Kondo, Chisato Fujimoto, Shinichi Iwasaki, Tatsuya Yamasoba, Toshiya Manabe
LABORATORY INVESTIGATION
(2018)
Article
Biology
Shinji Urata, Tadatsune Iida, Masamichi Yamamoto, Yu Mizushima, Chisato Fujimoto, Yu Matsumoto, Tatsuya Yamasoba, Shigeo Okabe
Article
Biochemistry & Molecular Biology
Anqi Tao, George Lo Huang, Kazunori Igarashi, Taehun Hong, Suiyang Liao, Francesco Stellacci, Yu Matsumoto, Tatsuya Yamasoba, Kazunori Kataoka, Horacio Cabral
MACROMOLECULAR BIOSCIENCE
(2020)
Article
Multidisciplinary Sciences
Sumiyo Watanabe, Kotaro Hayashi, Kazuko Toh, Hyun Jin Kim, Xueying Liu, Hiroyuki Chaya, Shigeto Fukushima, Keisuke Katsushima, Yutaka Kondo, Satoshi Uchida, Satomi Ogura, Takahiro Nomoto, Hiroyasu Takemoto, Horacio Cabral, Hiroaki Kinoh, Hiroyoshi Y. Tanaka, Mitsunobu R. Kano, Yu Matsumoto, Hiroshi Fukuhara, Shunya Uchida, Masaomi Nangaku, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
NATURE COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Yuta Inoue, Yu Matsumoto, Kazuko Toh, Kazuki Miyano, Horacio Cabral, Kazunori Igarashi, Shinichi Iwasaki, Kazunori Kataoka, Tatsuya Yamasoba
Summary: Improving the efficiency of drug delivery systems by manipulating nano-eruptions is a major goal in polymeric micelle research. Compounds like a TGF-beta inhibitor and chloroquine were found to have beneficial effects on intratumoral distribution of DDSs through different mechanisms.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Clinical Neurology
Tsukasa Uranaka, Yu Matsumoto, Yujiro Hoshi, Shinichi Iwasaki, Akinobu Kakigi, Tatsuya Yamasoba
Summary: Preoperative CT scans can predict the variable surgical anatomy of the chorda tympani nerve, which can be classified into five types based on endoscopic tympanotomy. The EAC type can be predicted by preoperative CT, while the other four types can be predicted by binning into two groups with a sensitivity of 0.61 and specificity of 0.72.
OTOLOGY & NEUROTOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Kazunori Igarashi, Horacio Cabral, Taehun Hong, Yasutaka Anraku, Fotios Mpekris, Triantafyllos Stylianopoulos, Thahomina Khan, Akira Matsumoto, Kazunori Kataoka, Yu Matsumoto, Tatsuya Yamasoba
Summary: Recent research has highlighted the potential of dynamic bursting in tumor vasculature as a novel route for drug delivery, allowing for the transportation of sub-100 nm nanoparticles into tumors and possibly affecting the access of other blood-borne particles. Mathematical modeling and experimental comparisons have revealed the characteristics and sizes of burst vents in tumor vasculature, as well as different types of therapeutic drugs and cells that can utilize this phenomenon for transportation.
Article
Polymer Science
Yasuhiro Nakagawa, Kotaro Ushidome, Keita Masuda, Kazunori Igarashi, Yu Matsumoto, Tatsuya Yamasoba, Yasutaka Anraku, Madoka Takai, Horacio Cabral
Summary: Multi-arm star-shaped block copolymers consisting of poly(furfuryl glycidol) (PFG) and poly(ethylene glycol) (PEG) were developed for drug delivery. The block copolymers showed controlled sizes and effectively loaded and released model drugs. When injected intravenously, they exhibited prolonged blood circulation, indicating their potential as long-circulating nanocarriers.
Article
Materials Science, Biomaterials
Yukiya Kitayama, Takuya Yamada, Kentaro Kiguchi, Aoi Yoshida, Shuhei Hayashi, Hiroaki Akasaka, Kazunori Igarashi, Yuya Nishimura, Yu Matsumoto, Ryohei Sasaki, Eri Takano, Hirobumi Sunayama, Toshifumi Takeuchi
Summary: A novel stealth radiation sensitizer based on Au-embedded molecularly imprinted polymer nanogels (Au MIP-NGs) was developed for low-dose X-ray radiation therapy. It showed good affinity and selectivity towards human serum albumin, and improved the efficiency of pancreatic cancer treatment in mouse models.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Engineering, Biomedical
Qixian Chen, Kensuke Osada, Zhishen Ge, Satoshi Uchida, Theofilus A. Tockary, Anjaneyulu Dirisala, Akitsugu Matsui, Kazuko Toh, Kaori M. Takeda, Xueying Liu, Takahiro Nomoto, Tekihiko Ishii, Makoto Oba, Yu Matsumoto, Kazunori Kataoka
Article
Chemistry, Multidisciplinary
Junjie Li, Anjaneyulu Dirisala, Zhishen Ge, Yuheng Wang, Wei Yin, Wendong Ke, Kazuko Toh, Jinbing Xie, Yu Matsumoto, Yasutaka Anraku, Kensuke Osada, Kazunori Kataoka
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
Article
Chemistry, Multidisciplinary
Toshifumi Takeuchi, Yukiya Kitayama, Reo Sasao, Takuya Yamada, Kazuko Toh, Yu Matsumoto, Kazunori Kataoka
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.