Review
Chemistry, Multidisciplinary
Mithun Rajendra Dethe, A. Prabakaran, Hafiz Ahmed, Mukta Agrawal, Upal Roy, Amit Alexander
Summary: Stimuli-responsive hydrogels have been extensively studied in biomedical applications due to their biodegradability and biocompatibility. The emergence of in situ stimuli-responsive hydrogels is the result of advancements in synthetic chemistry and materials science. The copolymer PCL-PEG, recognized by the FDA, can form thermosensitive injectable hydrogels that exhibit rapid and reversible gelation behavior.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Mohammad Norouzi, Javad Firouzi, Niloufar Sodeifi, Marzieh Ebrahimi, Donald W. Miller
Summary: Local drug delivery approaches using Pluronic and PLGA-PEG-PLGA copolymers for salinomycin in the treatment of glioblastoma showed that Pluronic exhibited better efficacy, biocompatibility, drug release profile, and cytotoxicity enhancement compared to PLGA-PEG-PLGA. Animal studies further demonstrated a significant reduction in tumor growth using Pluronic + salinomycin hydrogel, suggesting its potential as a localized treatment option for glioblastoma.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Analytical
Tong-dai Huang, Yu-yu Cao, Yun-jing Jiang, Bei-bei Zhai, Rong-xian Bai, Jie Wu, Xiang-yu You, Hong-mei Sun
Summary: The development of a smart hydrogel platform with shape adaptability and excellent antibacterial activity for treating bacteria-infected wound is highly demanded. An injectable thermosensitive hydrogel with adhesive and photothermal antibacterial activity was prepared by combining biocompatible chitosan (CS), β-sodium glycerophosphate (β-GP), and polydopamine nanoparticles (PDA NPs) via hydrogen bonding and Schiff base bond. The as-prepared CHI-C/β-GP/PDA hydrogel with good biocompatibility, excellent photothermal conversion ability, and fantastic antibacterial effect could be injected directly in the irregular wounds of mice to form the hydrogel in situ, showing great potential for promoting bacteria-infected wound healing.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Ru Zhang, Cuiwen Liu, Chengmeng Wei, Jingtao Huang, Xiaohui Zou, Yanxian Feng, Song Ang, Suqin Guo, Jinqing Qu, Ning Qing, Chengcheng Tang, Xiaoqing Zhou, Min Chen, Liuyan Tang
Summary: Here, a series of hydrogels (CT-hydrogels) with charge transfer complex are designed and synthesized. These hydrogels have rapid self-healing property, injectability, thermosensitivity, good adhesive strength on skin, and excellent antibacterial performance. They also exhibit high wound healing rate and promote neovascularization in diabetic wound healing.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Seung Hun Park, Richard S. Kim, Wesley R. Stiles, Minjoo Jo, Lingxue Zeng, Sunghoon Rho, Yoonji Baek, Jonghan Kim, Moon Suk Kim, Homan Kang, Hak Soo Choi
Summary: Deferoxamine (DFO) is an FDA-approved iron-chelating agent with good therapeutic efficacy, but its short blood half-life poses challenges for patients who require frequent administrations. By integrating crosslinked hyaluronic acid and Pluronic F127 into an injectable hydrogel formulation, a prolonged release of DFO nanochelators is achieved, significantly extending the half-life and demonstrating potential for the treatment of iron overload disorders.
Article
Pharmacology & Pharmacy
Mirian A. Gonzalez-Ayon, Jacob Licea-Rodriguez, Eugenio R. Mendez, Angel Licea-Claverie
Summary: Dual-function nanogels synthesized via surfactant-free emulsion polymerization can act as smart carriers for synergistic chemo- and photothermal therapy. Galacto-functionalized nanogels exhibit efficient drug release ability in in vitro experiments. Additionally, the presence of gold nanorods leads to enhanced drug release under laser irradiation.
Article
Pharmacology & Pharmacy
Hanmei Li, Qi Tang, Yao Wang, Mao Li, Yannan Wang, Hong Zhu, Fang Geng, Di Wu, Lianxin Peng, Gang Zhao, Liang Zou, Sanjun Shi
Summary: By encapsulating ropivacaine into liposomes and loading them into Poloxamer 407-based thermosensitive hydrogels, a system has been developed to prolong local anesthesia after a single injection. This system shows promising results in in vitro and in vivo studies, demonstrating small initial burst release, long-term nerve blockade, and good biocompatibility.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Applied
Phuong Anh Dang, Carla Palomino-Durand, Mohamed Elsafi Mabrouk, Pierre Marquaille, Clement Odier, Sophie Norvez, Emmanuel Pauthe, Laurent Corte
Summary: This study presents a rational design of injectable thermosensitive chitosan systems for cell encapsulation and delivery using mixtures of two phosphate salts. The gelation kinetics can be finely tuned through adjusting pH and salt-glucosamine ratios. The formulations with physiological pH and osmolarity demonstrated a liquid state for over 2 hours at 20 degrees C and formed a porous gel within 2 minutes at 37 degrees C.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Medicinal
Chih-Hao Chen, Hao-Hsi Kao, Yen-Chen Lee, Jyh-Ping Chen
Summary: In this study, a thermosensitive hyaluronic acid-g-poly(N-isopropylacrylamide) copolymer was synthesized and found to have sol-to-gel phase transition temperatures suitable for use as a scaffold for chondrocyte delivery. In vitro cell culture experiments showed that cells could proliferate in the polymer scaffold with full retention of cell viability and exhibit the phenotypic morphology of chondrocytes. In vivo studies confirmed the formation of ectopic cartilage when the polymer was used as a cell delivery vehicle. These findings suggest the promising potential of the thermosensitive hydrogel in cartilage tissue engineering applications.
Article
Engineering, Environmental
Jiating Liu, Yueyun Zhou, Jiawei Lu, Rong Cai, Tian Zhao, Ying Chen, Mengxue Zhang, Xiang Lu, Yi Chen
Summary: This study proposes a zwitterionic strategy to improve the 3D printing of high-strength hydrogel by electrostatic reversible interaction, resulting in a dual network hydrogel with high strength, ductility, and multiple functionalities. The developed hydrogel also exhibits impressive strain sensitivity, making it suitable for flexible sensor applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Adam Kasinski, Monika Zielinska-Pisklak, Sebastian Kowalczyk, Andrzej Plichta, Anna Zgadzaj, Ewa Oledzka, Marcin Sobczak
Summary: The paper developed injectable, thermosensitive smart hydrogel local drug delivery systems releasing the model antitumour drug 5-fluorouracil (5-FU). The biodegradable triblock copolymers synthesized through ring opening polymerization showed a sharp sol-gel transition at physiological temperature, with good mechanical properties at 37°C. In vitro release kinetics characterization indicated good control, with a total drug release time of approximately 12 hours.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Jomarien Garcia-Couce, Timo Schomann, Chih Kit Chung, Ivo Que, Carla Jorquera-Cordero, Gaston Fuentes, Amisel Almirall, Alan Chan, Luis J. Cruz
Summary: In recent years, there has been significant interest in intra-articular drug administration and modified drugs for the treatment of osteoarthritis. This study successfully prepared injectable-thermosensitive hydrogels for intra-articular administration of Etanercept (ETA) and demonstrated their cytocompatibility and controlled release of ETA. In vivo studies also showed their potential for localized treatment of joints in osteoarthritic mice.
Article
Nanoscience & Nanotechnology
Han Huang, Yan Su, Chenxi Wang, Bing Lei, Xuejiao Song, Wenjun Wang, Pan Wu, Xiyu Liu, Xiaochen Dong, Liping Zhong
Summary: The development of hydrogel dressings with injectability, adhesion, antibacterial properties, and wound healing promotion is urgently needed. The design of multifunctional injectable hydrogels based on Ag-doped Mo2C-derived polyoxometalate (AgPOM) nanoparticles, urea, gelatin, and tea polyphenols (TPs) has been presented for antibacterial and wound healing acceleration. The hydrogel exhibits excellent tissue adhesion after injection due to the in situ formation triggered by recombination of TPs and gelatin chains. AgPOM in the hydrogel acts as an antimicrobial agent by generating singlet oxygen and sterilizing under near-infrared light. In vitro studies demonstrate high bactericidal ability against drug-resistant Staphylococcus aureus and facilitate wound healing through synergistic photothermal/chemodynamic therapy. Therefore, the injectable hydrogel with AgPOM offers a novel therapeutic agent for drug-resistant bacteria-infected wounds and wound healing promotion.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Pritiranjan Mondal, Indranil Chakraborty, Kaushik Chatterjee
Summary: Injectable bioadhesives have advantages in surgery. This review summarizes the key features, design requirements, gelation mechanism, synthesis routes, and role of adhesion mechanisms and strategies in different biomedical applications of polymeric injectable hydrogels as bioadhesives or sealants. Deep understanding of the underlying materials chemistry principles can facilitate the translation of bioadhesive technologies into clinically-relevant products.
Article
Polymer Science
Xiaoran Wang, Zizhen Yang, Zhaowei Meng, Shao-Kai Sun
Summary: The study proposed a flexible and adjustable strategy to transform commercial metal sulfides into injectable hydrogels for local photothermal therapy. By dispersing CuS powders as photoabsorbers in a hydrogel, a CuS hydrogel with good injectability and low cost was synthesized. In vitro experiments showed that the hydrogel has good photothermal heating ability and can effectively destroy tumor cells under 1064 nm laser irradiation.