Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells

The Tumor Suppressor PALB2: Inside Out

(2019) Mandy Ducy et al.   TRENDS IN BIOCHEMICAL SCIENCES

BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation

(2019) Dali Zong et al.   MOLECULAR CELL

Antiparallel Coiled-Coil Interactions Mediate the Homodimerization of the DNA Damage-Repair Protein PALB2

(2018) Fei Song et al.   BIOCHEMISTRY

Coupling of Homologous Recombination and the Checkpoint by ATR

(2017) Rémi Buisson et al.   MOLECULAR CELL

Rad52 Inverse Strand Exchange Drives RNA-Templated DNA Double-Strand Break Repair

(2017) Olga M. Mazina et al.   MOLECULAR CELL

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

(2017) Weixing Zhao et al.   NATURE

Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif

(2017) Joris Pauty et al.   NUCLEIC ACIDS RESEARCH

MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress

(2017) Jean-Yves Bleuyard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human RAD52 Captures and Holds DNA Strands, Increases DNA Flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination

(2017) Ineke Brouwer et al.   Cell Reports

A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation

(2017) Martijn S Luijsterburg et al.   eLife

Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry

(2015) Weixing Zhao et al.   MOLECULAR CELL

A mechanism for the suppression of homologous recombination in G1 cells

(2015) Alexandre Orthwein et al.   NATURE

Crystal structure of Hop2–Mnd1 and mechanistic insights into its role in meiotic recombination

(2015) Hyun-Ah Kang et al.   NUCLEIC ACIDS RESEARCH

Nuclear domain ‘knock-in’ screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing

(2015) Jordan Pinder et al.   NUCLEIC ACIDS RESEARCH

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

(2015) Rohit Prakash et al.   Cold Spring Harbor Perspectives in Biology

Exploring the roles of PALB2 at the crossroads of DNA repair and cancer

(2014) Joris Pauty et al.   BIOCHEMICAL JOURNAL

PALB2: The hub of a network of tumor suppressors involved in DNA damage responses

(2014) Jung-Young Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

RecO Protein Initiates DNA Recombination and Strand Annealing through Two Alternative DNA Binding Mechanisms

(2014) Mikhail Ryzhikov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2

(2014) A. R. Venkitaraman   SCIENCE

Breast Cancer Proteins PALB2 and BRCA2 Stimulate Polymerase η in Recombination-Associated DNA Synthesis at Blocked Replication Forks

(2014) Rémi Buisson et al.   Cell Reports

A dual role for mycobacterial RecO in RecA-dependent homologous recombination and RecA-independent single-strand annealing

(2013) Richa Gupta et al.   NUCLEIC ACIDS RESEARCH

Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair

(2013) J-Y Park et al.   ONCOGENE

A Classification Model for BRCA2 DNA Binding Domain Missense Variants Based on Homology-Directed Repair Activity

(2012) L. Guidugli et al.   CANCER RESEARCH

PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear Accumulation and Function

(2012) J. Ma et al.   MOLECULAR AND CELLULAR BIOLOGY

Direct imaging of RecA nucleation and growth on single molecules of SSB-coated ssDNA

(2012) Jason C. Bell et al.   NATURE

PALB2 self-interaction controls homologous recombination

(2012) Rémi Buisson et al.   NUCLEIC ACIDS RESEARCH

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding

(2011) Masayoshi Honda et al.   EMBO JOURNAL

ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair

(2011) Jean-Yves Bleuyard et al.   EMBO REPORTS

Vital Roles of the Second DNA-binding Site of Rad52 Protein in Yeast Homologous Recombination

(2011) Naoto Arai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of RecO recruitment to DNA by single-stranded DNA binding protein

(2011) Mikhail Ryzhikov et al.   NUCLEIC ACIDS RESEARCH

Plasticity of BRCA2 Function in Homologous Recombination: Genetic Interactions of the PALB2 and DNA Binding Domains

(2011) Nicolas Siaud et al.   PLoS Genetics

MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks

(2010) T. Hayakawa et al.   JOURNAL OF CELL SCIENCE

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

(2010) Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA

(2010) Tina Thorslund et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

(2010) Sophie Badie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

(2010) Rémi Buisson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2

(2010) Eloïse Dray et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52–ssDNA complexes

(2010) Jill M. Grimme et al.   NUCLEIC ACIDS RESEARCH

How the Fanconi Anemia Pathway Guards the Genome

(2009) George-Lucian Moldovan et al.   Annual Review of Genetics

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

(2009) Feng Zhang et al.   CURRENT BIOLOGY

Structural basis for recruitment of BRCA2 by PALB2

(2009) Antony W Oliver et al.   EMBO REPORTS

MRG15 Is a Novel PALB2-interacting Factor Involved in Homologous Recombination

(2009) Shirley M.-H. Sy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PALB2 Regulates Recombinational Repair through Chromatin Association and Oligomerization

(2009) Shirley M.-H. Sy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2

(2009) F. Zhang et al.   MOLECULAR CANCER RESEARCH

Second-End Capture in DNA Double-Strand Break Repair Promoted by Brh2 Protein of Ustilago maydis

(2009) Nayef Mazloum et al.   MOLECULAR CELL

Rad52 promotes second-end DNA capture in double-stranded break repair to form complement-stabilized joint molecules

(2009) A. V. Nimonkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

(2009) S. M. H. Sy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RecFOR and RecOR as Distinct RecA Loading Pathways

(2008) Akiko Sakai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction with RPA Is Necessary for Rad52 Repair Center Formation and for Its Mediator Activity

(2008) Iben Plate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Anatomy of the Recombination Mediator Function ofSaccharomyces cerevisiaeRad52

(2008) Changhyun Seong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Repair Synthesis Facilitates RAD52-Mediated Second-End Capture during DSB Repair

(2008) Michael J. McIlwraith et al.   MOLECULAR CELL

Mechanism of homologous recombination from the RecA–ssDNA/dsDNA structures

(2008) Zhucheng Chen et al.   NATURE