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(2019) Xingrui He et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

A Sex-Stratified Genome-Wide Association Study of Tuberculosis Using a Multi-Ethnic Genotyping Array

(2019) Haiko Schurz et al.   Frontiers in Genetics

Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs

(2018) Massimo Gadina et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives

(2018) Laurent Abel et al.   LANCET INFECTIOUS DISEASES

Trends in tuberculosis in the UK

(2018) Philippe Glaziou et al.   THORAX

The Beaker phenomenon and the genomic transformation of northwest Europe

(2018) Iñigo Olalde et al.   NATURE

Phase 2 Trial of Selective Tyrosine Kinase 2 Inhibition in Psoriasis

(2018) Kim Papp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Management of Multidrug-Resistant Tuberculosis

(2018) Jose Caminero et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese

(2018) Ruijuan Zheng et al.   Nature Communications

Investigating the prevalence of latent Tuberculosis infection in a UK remand prison

(2018) Benjamin J Gray et al.   JOURNAL OF PUBLIC HEALTH

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

An atlas of genetic associations in UK Biobank

(2018) Oriol Canela-Xandri et al.   NATURE GENETICS

Discovery of susceptibility loci associated with tuberculosis in Han Chinese

(2017) Hui Qi et al.   HUMAN MOLECULAR GENETICS

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

(2017) Keertan Dheda et al.   Lancet Respiratory Medicine

A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals

(2016) Rafal S. Sobota et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A genome-wide association study of pulmonary tuberculosis in Morocco

(2016) A. V. Grant et al.   HUMAN GENETICS

HLA class II sequence variants influence tuberculosis risk in populations of European ancestry

(2016) Gardar Sveinbjornsson et al.   NATURE GENETICS

Whole-exome sequencing to analyze population structure, parental inbreeding, and familial linkage

(2016) Aziz Belkadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

(2016) C. A. Dendrou et al.   Science Translational Medicine

Primary Immunodeficiencies and Inflammatory Disease: A Growing Genetic Intersection

(2016) Nassima Fodil et al.   TRENDS IN IMMUNOLOGY

The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical Modelling

(2016) Rein M. G. J. Houben et al.   PLOS MEDICINE

Inherited and acquired immunodeficiencies underlying tuberculosis in childhood

(2015) Stéphanie Boisson-Dupuis et al.   IMMUNOLOGICAL REVIEWS

The Industrial Revolution and the decline in death rates from tuberculosis

(2015) J. F. Murray   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

(2015) Alexandra Y. Kreins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration

(2015) James Curtis et al.   NATURE GENETICS

The impact of host genetic variation on infection with HIV-1

(2015) Paul J McLaren et al.   NATURE IMMUNOLOGY

TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits

(2015) Dorothée Diogo et al.   PLoS One

Human genetic basis of interindividual variability in the course of infection

(2015) Jean-Laurent Casanova   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Severe infectious diseases of childhood as monogenic inborn errors of immunity

(2015) Jean-Laurent Casanova   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accuracy of Patient Self-Report of Stroke: A Systematic Review from the UK Biobank Stroke Outcomes Group

(2015) Rebecca Woodfield et al.   PLoS One

The ongoing challenge of latent tuberculosis

(2014) H. Esmail et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mendelian susceptibility to mycobacterial disease: Genetic, immunological, and clinical features of inborn errors of IFN-γ immunity

(2014) Jacinta Bustamante et al.   SEMINARS IN IMMUNOLOGY

Distilling Pathophysiology from Complex Disease Genetics

(2013) Aravinda Chakravarti et al.   CELL

Genome-wide association study of ancestry-specific TB risk in the South African Coloured population

(2013) E. R. Chimusa et al.   HUMAN MOLECULAR GENETICS

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

(2013) Adrian Cortes et al.   NATURE GENETICS

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

Simple Genetics for a Complex Disease

(2013) J. C. Cohen et al.   SCIENCE

A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians

(2012) Eileen Png et al.   BMC Medical Genetics

Genome-wide association studies of tuberculosis in Asians identify distinct at-risk locus for young tuberculosis

(2012) Surakameth Mahasirimongkol et al.   JOURNAL OF HUMAN GENETICS

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Common variants at 11p13 are associated with susceptibility to tuberculosis

(2012) Thorsten Thye et al.   NATURE GENETICS

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

(2012) Lam C Tsoi et al.   NATURE GENETICS

Totally Drug-Resistant Tuberculosis in India

(2011) Z. F. Udwadia et al.   CLINICAL INFECTIOUS DISEASES

The incubation period distribution of tuberculosis estimated with a molecular epidemiological approach

(2011) M. W. Borgdorff et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Lethal Tuberculosis in a Previously Healthy Adult with IL-12 Receptor Deficiency

(2011) Payam Tabarsi et al.   JOURNAL OF CLINICAL IMMUNOLOGY

IL-12Rβ1 Deficiency in Two of Fifty Children with Severe Tuberculosis from Iran, Morocco, and Turkey

(2011) Stéphanie Boisson-Dupuis et al.   PLoS One

Genetic Heterogeneity in Human Disease

(2010) Jon McClellan et al.   CELL

Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2

(2010) Thorsten Thye et al.   NATURE GENETICS

Rate of Latent Tuberculosis Infection Detected by Occupational Health Screening of Nurses New to a London Teaching Hospital

(2009) Priya Khanna et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY