Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

optiCall: a robust genotype-calling algorithm for rare, low-frequency and common variants

(2012) T. S. Shah et al.   BIOINFORMATICS

Convergence of the ZMIZ1 and NOTCH1 Pathways at C-MYC in Acute T Lymphoblastic Leukemias

(2012) L. A. Rakowski et al.   CANCER RESEARCH

Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro

(2012) Yoshiko Onozawa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Acidosis Promotes Bcl-2 Family-mediated Evasion of Apoptosis

(2012) Christopher Ryder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing

(2012) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

A 17q12 Allele Is Associated with Altered NK Cell Subsets and Function

(2012) Z. Xia et al.   JOURNAL OF IMMUNOLOGY

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

(2012) Adam P. Gregory et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Chromatin marks identify critical cell types for fine mapping complex trait variants

(2012) Gosia Trynka et al.   NATURE GENETICS

Interleukin-7-aggravated joint inflammation and tissue destruction in collagen-induced arthritis is associated with T-cell and B-cell activation

(2012) Sarita AY Hartgring et al.   ARTHRITIS RESEARCH & THERAPY

Enrichment of circulating interleukin-17-secreting interleukin-23 receptor-positive γ/δ T cells in patients with active ankylosing spondylitis

(2011) Tony J. Kenna et al.   ARTHRITIS AND RHEUMATISM

Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme

(2011) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Identification of IL6R and chromosome 11q13.5 as risk loci for asthma

(2011) Manuel AR Ferreira et al.   LANCET

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

(2011) Gosia Trynka et al.   NATURE GENETICS

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

(2011) Zhiming Lin et al.   NATURE GENETICS

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

FaST linear mixed models for genome-wide association studies

(2011) Christoph Lippert et al.   NATURE METHODS

A common functional variant of endoplasmic reticulum aminopeptidase 2 (ERAP2) that reduces major histocompatibility complex class I expression is not associated with ankylosing spondylitis

(2011) D. Harvey et al.   RHEUMATOLOGY

Promise and pitfalls of the Immunochip

(2011) Adrian Cortes et al.   ARTHRITIS RESEARCH & THERAPY

Analysis of IL-17+ cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response

(2011) Heiner Appel et al.   ARTHRITIS RESEARCH & THERAPY

Quantitative Trait Loci for CD4:CD8 Lymphocyte Ratio Are Associated with Risk of Type 1 Diabetes and HIV-1 Immune Control

(2010) Manuel A.R. Ferreira et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Different response to rituximab in tumor necrosis factor blocker-naive patients with active ankylosing spondylitis and in patients in whom tumor necrosis factor blockers have failed: A twenty-four-week clinical trial

(2010) I.-H. Song et al.   ARTHRITIS AND RHEUMATISM

LocusZoom: regional visualization of genome-wide association scan results

(2010) R. J. Pruim et al.   BIOINFORMATICS

HLA Class I and Genetic Susceptibility to Type 1 Diabetes: Results From the Type 1 Diabetes Genetics Consortium

(2010) J. A. Noble et al.   DIABETES

Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch

(2010) Akihiko Muto et al.   EMBO JOURNAL

MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes

(2010) Yun Li et al.   GENETIC EPIDEMIOLOGY

The Transcription Factor GATA3 Actively Represses RUNX3 Protein-Regulated Production of Interferon-γ

(2010) Ryoji Yagi et al.   IMMUNITY

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci

(2010) Nobuhisa Mizuki et al.   NATURE GENETICS

Genome-wide association study identifies variants in the MHC class I, IL10 and IL23R-IL12RB2 regions associated with Behçet's disease

(2010) Elaine F Remmers et al.   NATURE GENETICS

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

(2010) John D Reveille et al.   NATURE GENETICS

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

(2010) Jung-Hyun Park et al.   NATURE IMMUNOLOGY

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Evidence for Significant Overlap between Common Risk Variants for Crohn's Disease and Ankylosing Spondylitis

(2010) Debby Laukens et al.   PLoS One

Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation

(2010) Aida M. Andrés et al.   PLoS Genetics

Association of Variants at 1q32 and STAT3 with Ankylosing Spondylitis Suggests Genetic Overlap with Crohn's Disease

(2010) Patrick Danoy et al.   PLoS Genetics

Familial Association of Inflammatory Bowel Diseases With Other Autoimmune and Related Diseases

(2009) Kari Hemminki et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis

(2009) F. W. L. Tsui et al.   ANNALS OF THE RHEUMATIC DISEASES

Association ofERAP1, but notIL23R, with ankylosing spondylitis in a Han Chinese population

(2009) Stuart I. Davidson et al.   ARTHRITIS AND RHEUMATISM

Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor

(2009) Maria Ban et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Strong Evidence of a Combination Polymorphism of the Tyrosine Kinase 2 Gene and the Signal Transducer and Activator of Transcription 3 Gene as a DNA-Based Biomarker for Susceptibility to Crohn’s Disease in the Japanese Population

(2009) Kayoko Sato et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

(2009) Fernando Cruz-Guilloty et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

Anomalous Type 17 Response to Viral Infection by CD8+ T Cells Lacking T-bet and Eomesodermin

(2008) A. M. Intlekofer et al.   SCIENCE

A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs)

(2008) David Melzer et al.   PLoS Genetics

Les manifestations articulaires de la maladie de Behçet. À propos de 79 cas

(2007) M.A. Ait Badi et al.   REVUE DE MEDECINE INTERNE