Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis

GW0742, a High Affinity PPAR-β/δ Agonist Reduces Lung Inflammation Induced by Bleomycin Instillation in Mice

(2017) M. Galuppo et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

PPARα-Deficient ob/ob Obese Mice Become More Obese and Manifest Severe Hepatic Steatosis Due to Decreased Fatty Acid Oxidation

(2015) Qian Gao et al.   AMERICAN JOURNAL OF PATHOLOGY

Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis

(2015) Jingang Huang et al.   ANNALS OF THE RHEUMATIC DISEASES

Comparative Analysis of the Expression of Surface Markers on Fibroblasts and Fibroblast-Like Cells Isolated from Different Human Tissues

(2015) A. Yu. Lupatov et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Systemic sclerosis: Recent insights

(2015) Muriel Elhai et al.   JOINT BONE SPINE

CD90 + Human Dermal Stromal Cells Are Potent Inducers of FoxP3 + Regulatory T Cells

(2015) Karin Pfisterer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis

(2015) Katrin Palumbo-Zerr et al.   NATURE MEDICINE

Advances in cohort enrichment shape future of trial design

(2015) Yannick Allanore et al.   Nature Reviews Rheumatology

Combined effect of genetic background and gender in a mouse model of bleomycin-induced skin fibrosis

(2015) Nadira Ruzehaji et al.   ARTHRITIS RESEARCH & THERAPY

Inhibitory Effects of PPARγ Ligands on TGF-β1–Induced Corneal Myofibroblast Transformation

(2014) Kye-Im Jeon et al.   AMERICAN JOURNAL OF PATHOLOGY

Fibrosis—a lethal component of systemic sclerosis

(2014) Yuen Yee Ho et al.   Nature Reviews Rheumatology

Transforming growth factor β—at the centre of systemic sclerosis

(2014) Robert Lafyatis   Nature Reviews Rheumatology

Targeting IL-6 by both passive or active immunization strategies prevents bleomycin-induced skin fibrosis

(2014) Lucille Desallais et al.   ARTHRITIS RESEARCH & THERAPY

The Nuclear Receptor Constitutive Androstane Receptor/NR1I3 Enhances the Profibrotic Effects of Transforming Growth Factor β and Contributes to the Development of Experimental Dermal Fibrosis

(2014) Jérôme Avouac et al.   Arthritis & Rheumatology

Attenuation of flightless I improves wound healing and enhances angiogenesis in a murine model of type 1 diabetes

(2013) Nadira Ruzehaji et al.   DIABETOLOGIA

Preclinical Studies of a Specific PPARγ Modulator in the Control of Skin Inflammation

(2013) Arianna Mastrofrancesco et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

(2013) Miki Okada-Iwabu et al.   NATURE

The Influence of Flightless I on Toll-Like-Receptor-Mediated Inflammation in a Murine Model of Diabetic Wound Healing

(2013) Nadira Ruzehaji et al.   Biomed Research International

Critical role of the adhesion receptor DNAX accessory molecule-1 (DNAM-1) in the development of inflammation-driven dermal fibrosis in a mouse model of systemic sclerosis

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Evaluation of the antifibrotic effect of fenofibrate and rosiglitazone on bleomycin-induced pulmonary fibrosis in rats

(2012) M. Samah et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Flightless, secreted through a late endosome/lysosome pathway, binds LPS and dampens cytokine secretion

(2012) N. Lei et al.   JOURNAL OF CELL SCIENCE

TGF-β signaling in fibrosis

(2011) Anna Biernacka et al.   GROWTH FACTORS

Animal models of systemic sclerosis: Prospects and limitations

(2010) Christian Beyer et al.   ARTHRITIS AND RHEUMATISM

PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

(2010) Jun Wei et al.   PLoS One

Rosiglitazone Abrogates Bleomycin-Induced Scleroderma and Blocks Profibrotic Responses Through Peroxisome Proliferator-Activated Receptor-γ

(2009) Minghua Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Peroxisome proliferator-activated receptor-γ abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator

(2009) Asish K. Ghosh et al.   FASEB JOURNAL

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Peroxisome Proliferator Activator Receptor Alpha/Delta Agonists Linoleic Acid and Bezafibrate Upregulate Osteoblast Differentiation and Induce Periosteal Bone Formation In Vivo

(2008) Karen Still et al.   CALCIFIED TISSUE INTERNATIONAL

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Pioglitazone, a Peroxisome Proliferator-Activated Receptor Gamma Ligand, Suppresses Bleomycin-Induced Acute Lung Injury and Fibrosis

(2008) Yasuhiro Aoki et al.   RESPIRATION