Crosstalk between Calcium and ROS in Pathophysiological Conditions

MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake

(2018) Maria Patron et al.   CELL DEATH AND DIFFERENTIATION

Calcium Signaling and Reactive Oxygen Species in Mitochondria

(2018) Edoardo Bertero et al.   CIRCULATION RESEARCH

Mitochondrial calcium uptake in organ physiology: from molecular mechanism to animal models

(2018) Cristina Mammucari et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Cryo-EM structure of a mitochondrial calcium uniporter

(2018) Jiho Yoo et al.   SCIENCE

X-ray and cryo-EM structures of the mitochondrial calcium uniporter

(2018) Chao Fan et al.   NATURE

Cryo-EM structure of a fungal mitochondrial calcium uniporter

(2018) Nam X. Nguyen et al.   NATURE

Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters

(2018) Rozbeh Baradaran et al.   NATURE

OSCP subunit of mitochondrial ATP synthase: role in regulation of enzyme function and of its transition to a pore

(2018) Valentina Giorgio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Akt‐mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth

(2018) Saverio Marchi et al.   EMBO JOURNAL

MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360

(2018) Melanie Paillard et al.   MOLECULAR CELL

Mitochondrial energetics and calcium coupling in the heart

(2017) Michael Kohlhaas et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondrial Ca 2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity

(2017) Zhiwei Dong et al.   MOLECULAR CELL

Antioxidant Treatment Reduces Formation of Structural Cores and Improves Muscle Function in RYR1Y522S/WT Mice

(2017) Antonio Michelucci et al.   Oxidative Medicine and Cellular Longevity

Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase

(2017) Jiuya He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase

(2017) Jiuya He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca 2+ Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU

(2017) Melanie Paillard et al.   Cell Reports

The Mitochondrial Voltage-Dependent Anion Channel 1, Ca2+ Transport, Apoptosis, and Their Regulation

(2017) Varda Shoshan-Barmatz et al.   Frontiers in Oncology

Enjoy the Trip: Calcium in Mitochondria Back and Forth

(2016) Diego De Stefani et al.   Annual Review of Biochemistry

Analysis of the structure and function of EMRE in a yeast expression system

(2016) Takenori Yamamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Molecular structure and pathophysiological roles of the Mitochondrial Calcium Uniporter

(2016) Cristina Mammucari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The mitochondrial permeability transition pore in AD 2016: An update

(2016) Lucia Biasutto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Alterations of calcium homeostasis in cancer cells

(2016) Saverio Marchi et al.   CURRENT OPINION IN PHARMACOLOGY

The mitochondrial calcium uniporter regulates breast cancer progression via HIF‐1α

(2016) Anna Tosatto et al.   EMBO Molecular Medicine

Unique Regulatory Properties of Heterotetrameric Inositol 1,4,5-Trisphosphate Receptors Revealed by Studying Concatenated Receptor Constructs

(2016) Rahul Chandrasekhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compartment-specific Control of Reactive Oxygen Species Scavenging by Antioxidant Pathway Enzymes

(2016) Swati Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A MICU1 Splice Variant Confers High Sensitivity to the Mitochondrial Ca 2+ Uptake Machinery of Skeletal Muscle

(2016) Denis Vecellio Reane et al.   MOLECULAR CELL

Architecture of the mitochondrial calcium uniporter

(2016) Kirill Oxenoid et al.   NATURE

Parkin and mitophagy in cancer

(2016) J P Bernardini et al.   ONCOGENE

Calcium, Reactive Oxygen Species, and Synaptic Plasticity

(2016) Cecilia Hidalgo et al.   PHYSIOLOGY

Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition

(2016) Dipayan Chaudhuri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes

(2016) Anna Raffaello et al.   TRENDS IN BIOCHEMICAL SCIENCES

MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload

(2016) Julia C. Liu et al.   Cell Reports

EMRE Is a Matrix Ca 2+ Sensor that Governs Gatekeeping of the Mitochondrial Ca 2+ Uniporter

(2016) Horia Vais et al.   Cell Reports

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors

(2015) Rahul Chandrasekhar et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

CCDC90A (MCUR1) Is a Cytochrome c Oxidase Assembly Factor and Not a Regulator of the Mitochondrial Calcium Uniporter

(2015) Vincent Paupe et al.   Cell Metabolism

The Ca2+-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca2+ Uptake

(2015) Carmelina Petrungaro et al.   Cell Metabolism

Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter

(2015) Y. Lee et al.   EMBO REPORTS

Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter

(2015) Kira M. Holmström et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury

(2015) Giampaolo Morciano et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The regulation of neuronal mitochondrial metabolism by calcium

(2015) I. Llorente-Folch et al.   JOURNAL OF PHYSIOLOGY-LONDON

The molecular era of the mitochondrial calcium uniporter

(2015) Kimberli J. Kamer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

(2015) Paolo Bernardi et al.   PHYSIOLOGICAL REVIEWS

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart

(2015) Tyler P. Rasmussen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mitochondrial uniporter controls fight or flight heart rate increases

(2015) Yuejin Wu et al.   Nature Communications

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Reports

Calcium and ROS: A mutual interplay

(2015) Agnes Görlach et al.   Redox Biology

Reperfusion injury and reactive oxygen species: The evolution of a concept

(2015) D. Neil Granger et al.   Redox Biology

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Unresolved questions from the analysis of mice lacking MCU expression

(2014) Elizabeth Murphy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuronal calcium signaling: function and dysfunction

(2014) Marisa Brini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake

(2014) L. Wang et al.   EMBO JOURNAL

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter

(2014) K. J. Kamer et al.   EMBO REPORTS

Channel Formation by Yeast F-ATP Synthase and the Role of Dimerization in the Mitochondrial Permeability Transition

(2014) Michela Carraro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial reactive oxygen species production and elimination

(2014) Alexander Nickel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

LTP and LTD in the Visual Cortex Require the Activation of NOX2

(2014) R. De Pasquale et al.   JOURNAL OF NEUROSCIENCE

MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

(2014) Maria Patron et al.   MOLECULAR CELL

Mitochondrial Ca2+ uniporter and CaMKII in heart

(2014) Francesca Fieni et al.   NATURE

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Reconstitution of the mitochondrial calcium uniporter in yeast

(2014) E. Kovacs-Bogdan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Management of malignant hyperthermia: diagnosis and treatment

(2014) Frank Schuster et al.   Therapeutics and Clinical Risk Management

Perturbed mitochondrial Ca2+signals as causes or consequences of mitophagy induction

(2013) Alessandro Rimessi et al.   Autophagy

Redox-Optimized ROS Balance and the relationship between mitochondrial respiration and ROS

(2013) Sonia Cortassa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

Oxidative Stress and Sarcomeric Proteins

(2013) Susan F. Steinberg   CIRCULATION RESEARCH

Nox4-Generated Superoxide Drives Angiotensin II-Induced Neural Stem Cell Proliferation

(2013) Elena Topchiy et al.   DEVELOPMENTAL NEUROSCIENCE

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

(2013) Anna Raffaello et al.   EMBO JOURNAL

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

(2013) Clare V Logan et al.   NATURE GENETICS

Reactive Oxygen Species and the Cardiovascular System

(2013) Yannick J. H. J. Taverne et al.   Oxidative Medicine and Cellular Longevity

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

(2013) Molly Plovanich et al.   PLoS One

Angiotensin II Increased Neuronal Stem Cell Proliferation: Role of AT2R

(2013) Jie Chao et al.   PLoS One

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

(2013) Jing Qiu et al.   Nature Communications

MT1-MMP–Dependent Remodeling of Cardiac Extracellular Matrix Structure and Function Following Myocardial Infarction

(2012) Gerald C. Koenig et al.   AMERICAN JOURNAL OF PATHOLOGY

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

(2012) Karthik Mallilankaraman et al.   CELL

Mitochondrial Ca2+ and neurodegeneration

(2012) Tito Calì et al.   CELL CALCIUM

Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25

(2012) Saverio Marchi et al.   CURRENT BIOLOGY

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

CaMKII determines mitochondrial stress responses in heart

(2012) Mei-ling A. Joiner et al.   NATURE

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes

(2012) I. Drago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity of the mitochondrial calcium uniporter varies greatly between tissues

(2012) Francesca Fieni et al.   Nature Communications

Direct regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patients

(2011) Hua She et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Reactive Oxygen Species Are Activated by mGluR5 through IP3 and Activate ERK and PKA to Increase Excitability of Amygdala Neurons and Pain Behavior

(2011) Z. Li et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Ca2+ Uptake Is Essential for Synaptic Plasticity in Pain

(2011) H. Y. Kim et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial calcium homeostasis as potential target for mitochondrial medicine

(2011) Carlotta Giorgi et al.   MITOCHONDRION

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

(2010) Cynthia A. Massaad et al.   ANTIOXIDANTS & REDOX SIGNALING

Ca2+-dependent autophagy is enhanced by the pharmacological agent PK11195

(2010) Annalisa Gastaldello et al.   Autophagy

Redox-optimized ROS balance: A unifying hypothesis

(2010) M.A. Aon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Voltage dependent anion channel-1 (VDAC-1) as an anti-cancer target

(2010) Saroj P. Mathupala et al.   CANCER BIOLOGY & THERAPY

Adverse Bioenergetic Consequences of Na + -Ca 2+ Exchanger–Mediated Ca 2+ Influx in Cardiac Myocytes

(2010) Michael Kohlhaas et al.   CIRCULATION

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Ca2+ Hot Spots on the Mitochondrial Surface Are Generated by Ca2+ Mobilization from Stores, but Not by Activation of Store-Operated Ca2+ Channels

(2010) Marta Giacomello et al.   MOLECULAR CELL

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

(2010) J. T. Lanner et al.   Cold Spring Harbor Perspectives in Biology

Ca2+ transfer from the ER to mitochondria: When, how and why

(2009) Rosario Rizzuto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

(2009) J M Vicencio et al.   CELL DEATH AND DIFFERENTIATION

Regulation of the Human Cardiac Mitochondrial Ca 2+ Uptake by 2 Different Voltage-Gated Ca 2+ Channels

(2009) Guido Michels et al.   CIRCULATION

A CaPful of mechanisms regulating the mitochondrial permeability transition

(2009) Fabio Di Lisa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Susceptibility to calcium dysregulation during brain aging

(2009) Ashok Kumar   Frontiers in Aging Neuroscience

RyR1 S-Nitrosylation Underlies Environmental Heat Stroke and Sudden Death in Y522S RyR1 Knockin Mice

(2008) William J. Durham et al.   CELL

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

(2008) Jeffrey R. Erickson et al.   CELL

Enhancing Mitochondrial Ca 2+ Uptake in Myocytes From Failing Hearts Restores Energy Supply and Demand Matching

(2008) Ting Liu et al.   CIRCULATION RESEARCH