Optical control of sphingosine-1-phosphate formation and function

In Vivo Photopharmacology

(2018) Katharina Hüll et al.   CHEMICAL REVIEWS

An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel

(2018) Michaela Lichtenegger et al.   Nature Chemical Biology

Understanding the diversity of membrane lipid composition

(2018) Takeshi Harayama et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The signaling lipid sphingosine 1-phosphate regulates mechanical pain

(2018) Rose Z Hill et al.   eLife

Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function

(2018) Suihan Feng et al.   eLife

S1PR3 Mediates Itch and Pain via Distinct TRP Channel-Dependent Pathways

(2018) Rose Z. Hill et al.   JOURNAL OF NEUROSCIENCE

Light-Controlled Membrane Mechanics and Shape Transitions of Photoswitchable Lipid Vesicles

(2017) Carla Pernpeintner et al.   LANGMUIR

Selectivity determinants of GPCR–G-protein binding

(2017) Tilman Flock et al.   NATURE

Optical control of GPR40 signalling in pancreatic β-cells

(2017) James Allen Frank et al.   Chemical Science

Ligand chain length drives activation of lipid G protein-coupled receptors

(2017) Anastassia Troupiotis-Tsaïlaki et al.   Scientific Reports

Detection of genome-edited mutant clones by a simple competition-based PCR method

(2017) Takeshi Harayama et al.   PLoS One

Optical Control of Lipid Rafts with Photoswitchable Ceramides

(2016) James Allen Frank et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoswitchable diacylglycerols enable optical control of protein kinase C

(2016) James Allen Frank et al.   Nature Chemical Biology

Ablation of Sphingosine 1-Phosphate Receptor Subtype 3 Impairs Hippocampal Neuron Excitability In vitro and Spatial Working Memory In vivo

(2016) Daniela Weth-Malsch et al.   Frontiers in Cellular Neuroscience

A Roadmap to Success in Photopharmacology

(2015) Johannes Broichhagen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy

(2015) Richard L. Proia et al.   JOURNAL OF CLINICAL INVESTIGATION

Sources, metabolism, and regulation of circulating sphingosine-1-phosphate

(2015) Monika Książek et al.   JOURNAL OF LIPID RESEARCH

INGA: protein function prediction combining interaction networks, domain assignments and sequence similarity

(2015) Damiano Piovesan et al.   NUCLEIC ACIDS RESEARCH

Photoswitchable fatty acids enable optical control of TRPV1

(2015) James Allen Frank et al.   Nature Communications

Caged lipids as tools for investigating cellular signaling

(2014) Doris Höglinger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Fat & fabulous: Bifunctional lipids in the spotlight

(2014) Per Haberkant et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis

(2014) Aline Xavier da Silveira dos Santos et al.   MOLECULAR BIOLOGY OF THE CELL

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

Sphingosine-1-Phosphate-Induced Nociceptor Excitation and Ongoing Pain Behavior in Mice and Humans Is Largely Mediated by S1P3 Receptor

(2013) M. Camprubi-Robles et al.   JOURNAL OF NEUROSCIENCE

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis

(2011) Brady K Atwood et al.   BMC GENOMICS

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

(2011) N. Takasugi et al.   JOURNAL OF NEUROSCIENCE

Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses

(2011) Xianlin Han et al.   MASS SPECTROMETRY REVIEWS

TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch

(2011) Sarah R Wilson et al.   NATURE NEUROSCIENCE

Genetic Evidence for Involvement of Neuronally Expressed S1P1 Receptor in Nociceptor Sensitization and Inflammatory Pain

(2011) Norbert Mair et al.   PLoS One

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Lipidomics: New Tools and Applications

(2010) Markus R. Wenk   CELL

Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis

(2010) Jerold Chun et al.   CLINICAL NEUROPHARMACOLOGY

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

An update on sphingosine-1-phosphate and other sphingolipid mediators

(2010) Henrik Fyrst et al.   Nature Chemical Biology

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Functional Interactions between Sphingolipids and Sterols in Biological Membranes Regulating Cell Physiology

(2009) Xue Li Guan et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics

(2008) Vitali Matyash et al.   JOURNAL OF LIPID RESEARCH

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY