Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome

Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions

(2018) Sophie Miquel et al.   AGEING RESEARCH REVIEWS

Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in aging C57BL/6J mice

(2018) Benthe van der Lugt et al.   Aging-US

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Feeding the developing brain: Juvenile rats fed diet rich in prebiotics and bioactive milk fractions exhibit reduced anxiety-related behavior and modified gene expression in emotion circuits

(2018) Agnieszka Mika et al.   NEUROSCIENCE LETTERS

Possible correlation between gut microbiota and immunity among healthy middle-aged and elderly people in southwest China

(2018) Xi Shen et al.   Gut Pathogens

Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations

(2018) Marcel van de Wouw et al.   JOURNAL OF PHYSIOLOGY-LONDON

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction

(2018) Laura K. Fonken et al.   NEUROBIOLOGY OF AGING

Butyrate and Dietary Soluble Fiber Improve Neuroinflammation Associated With Aging in Mice

(2018) Stephanie M. Matt et al.   Frontiers in Immunology

Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells

(2018) Monica Bodogai et al.   Science Translational Medicine

Gas chromatography – mass spectrometry data processing made easy

(2017) Lea G. Johnsen et al.   JOURNAL OF CHROMATOGRAPHY A

Cafeteria diet and probiotic therapy: cross talk among memory, neuroplasticity, serotonin receptors and gut microbiota in the rat

(2017) J E Beilharz et al.   MOLECULAR PSYCHIATRY

Interactions between the microbiota, immune and nervous systems in health and disease

(2017) Thomas C Fung et al.   NATURE NEUROSCIENCE

High-dimensional, single-cell characterization of the brain's immune compartment

(2017) Ben Korin et al.   NATURE NEUROSCIENCE

Feeding the microbiota-gut-brain axis: diet, microbiome, and neuropsychiatry

(2017) Kiran V. Sandhu et al.   Translational Research

Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

(2017) Patrick Smith et al.   eLife

Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

(2017) Floris Fransen et al.   Frontiers in Immunology

Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity

(2017) Claudio Franceschi et al.   Frontiers in Immunology

Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study

(2016) Toshitaka Odamaki et al.   BMC MICROBIOLOGY

Gut Microbiota and Extreme Longevity

(2016) Elena Biagi et al.   CURRENT BIOLOGY

Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration

(2016) Timothy G. Dinan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

(2016) Tuan Leng Tay et al.   JOURNAL OF PHYSIOLOGY-LONDON

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

(2016) Anthony J. Filiano et al.   NATURE

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

The Human Intestinal Microbiome in Health and Disease

(2016) Susan V. Lynch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-dependent differences in microglial responses to systemic inflammation are evident as early as middle age

(2016) Maria Nikodemova et al.   PHYSIOLOGICAL GENOMICS

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

(2016) Nicholas H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ly6Chi Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis

(2016) Luisa Möhle et al.   Cell Reports

Dietary Polyphenol Supplementation Prevents Alterations of Spatial Navigation in Middle-Aged Mice

(2016) Julien Bensalem et al.   Frontiers in Behavioral Neuroscience

Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age

(2016) Hirotaka Shoji et al.   Molecular Brain

Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists

(2016) Zhiwei Ang et al.   Scientific Reports

Bifidobacteria modulate cognitive processes in an anxious mouse strain

(2015) H.M. Savignac et al.   BEHAVIOURAL BRAIN RESEARCH

The prebiotics 3′Sialyllactose and 6′Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut–brain axis

(2015) Andrew J. Tarr et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents

(2015) Enrique Vázquez et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain

(2015) C.M. Sawicki et al.   NEUROSCIENCE

Adding fuel to the fire: the impact of stress on the ageing brain

(2015) Jack A. Prenderville et al.   TRENDS IN NEUROSCIENCES

Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy

(2014) João M.N. Duarte et al.   NEUROBIOLOGY OF AGING

Toll-like receptor 2-mediated alternative activation of microglia is protective after spinal cord injury

(2013) David P. Stirling et al.   BRAIN

Stress-Induced Recruitment of Bone Marrow-Derived Monocytes to the Brain Promotes Anxiety-Like Behavior

(2013) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Aging enhances classical activation but mitigates alternative activation in the central nervous system

(2013) Daniel C. Lee et al.   NEUROBIOLOGY OF AGING

Differential effects of duration and age on the consequences of neuroinflammation in the hippocampus

(2013) Isabelle Bardou et al.   NEUROBIOLOGY OF AGING

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: A putative model of gene×environment interaction

(2012) Lieve Desbonnet et al.   BRAIN BEHAVIOR AND IMMUNITY

Gut microbiota composition correlates with diet and health in the elderly

(2012) Marcus J. Claesson et al.   NATURE

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Dynamic 5-HT2C Receptor Editing in a Mouse Model of Obesity

(2012) Harriët Schellekens et al.   PLoS One

Stress-induced redistribution of immune cells—From barracks to boulevards to battlefields: A tale of three hormones – Curt Richter Award Winner

(2012) Firdaus S. Dhabhar et al.   PSYCHONEUROENDOCRINOLOGY

Regulation of Inflammation by Short Chain Fatty Acids

(2011) Marco A.R. Vinolo et al.   Nutrients

Search and clustering orders of magnitude faster than BLAST

(2010) Robert C. Edgar   BIOINFORMATICS

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

Analytical platform for metabolome analysis of microbial cells using methyl chloroformate derivatization followed by gas chromatography–mass spectrometry

(2010) Kathleen F Smart et al.   Nature Protocols

Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

(2010) Elena Biagi et al.   PLoS One

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

(2010) M. J. Claesson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of lifelong intervention with an oligofructose-enriched inulin in rats on general health and lifespan

(2008) Pascale Rozan et al.   BRITISH JOURNAL OF NUTRITION

Murine neutrophils present Class II restricted antigen

(2008) Shauna Culshaw et al.   IMMUNOLOGY LETTERS

Ly6c+“inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis

(2008) Daniel R. Getts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuroinflammation Associated with Aging Sensitizes the Brain to the Effects of Infection or Stress

(2008) Nathan L. Sparkman et al.   NEUROIMMUNOMODULATION

Detailed analysis of the behavior and memory performance of middle-aged male and female CD-1 mice in a 3D maze☆

(2007) A ENNACEUR et al.   BEHAVIOURAL BRAIN RESEARCH