Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists

Safety, pharmacokinetics and pharmacodynamics of GLPG0974, a potent and selective FFA2 antagonist, in healthy male subjects

(2016) Florence Namour et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

GPR41 and GPR43 in Obesity and Inflammation – Protective or Causative?

(2016) Zhiwei Ang et al.   Frontiers in Immunology

An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion

(2015) Medha Priyadarshini et al.   MOLECULAR ENDOCRINOLOGY

Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes

(2015) Cong Tang et al.   NATURE MEDICINE

The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes

(2015) Zhiwei Ang et al.   Scientific Reports

Commensal Gram-positive bacteria initiates colitis by inducing monocyte/macrophage mobilization

(2014) Y Nakanishi et al.   Mucosal Immunology

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells

(2014) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Arrestin 2 Mediates G Protein-Coupled Receptor 43 Signals to Nuclear Factor-κB

(2013) Su Ui Lee et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

G Protein-Coupled Receptor 43 Moderates Gut Inflammation Through Cytokine Regulation from Mononuclear Cells

(2013) Ryuta Masui et al.   INFLAMMATORY BOWEL DISEASES

Evaluation of the relationship between GPR43 and adiposity in human

(2013) Evelyne M Dewulf et al.   Nutrition & Metabolism

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

(2012) C C Bain et al.   Mucosal Immunology

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

HLA-DRhi and CCR9 Define a Pro-Inflammatory Monocyte Subset in IBD

(2012) Ludvig Linton et al.   Clinical and Translational Gastroenterology

Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets

(2012) Trond Ulven   Frontiers in Endocrinology

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Mouse and human intestinal immunity: same ballpark, different players; different rules, same score

(2011) D L Gibbons et al.   Mucosal Immunology

SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor

(2011) Marco A. R. Vinolo et al.   PLoS One

Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet

(2010) Mikael Bjursell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Blockade of Dendritic Cell Development by Bacterial Fermentation Products Butyrate and Propionate through a Transporter (Slc5a8)-dependent Inhibition of Histone Deacetylases

(2010) Nagendra Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gq-coupled Purinergic Receptors Inhibit Insulin-like Growth Factor-I/Phosphoinositide 3-Kinase Pathway-dependent Keratinocyte Migration

(2010) Salma Taboubi et al.   MOLECULAR BIOLOGY OF THE CELL

The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators

(2009) Yingcai Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Comparison of gene expression profiles between human and mouse monocyte subsets

(2009) M. A. Ingersoll et al.   BLOOD

GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

(2009) M. Thangaraju et al.   CANCER RESEARCH

Short chain fatty acids exchange across the gut and liver in humans measured at surgery

(2009) Johanne G. Bloemen et al.   CLINICAL NUTRITION

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Fine-tuning of GPCR activity by receptor-interacting proteins

(2009) Stefanie L. Ritter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

Short-chain fatty acids act as antiinflammatory mediatorsby regulating prostaglandin E2 and cytokines

(2009) Mary Ann Cox et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications

(2008) T Weichhart et al.   ANNALS OF THE RHEUMATIC DISEASES

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

(2008) Tomohiro Kawamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

G Protein–Coupled Receptor Connectivity to NF-κB in Inflammation and Cancer

(2008) Christopher C. Fraser   INTERNATIONAL REVIEWS OF IMMUNOLOGY