Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

Dynamic microglial modulation of spatial learning and social behavior

(2016) Luisa Torres et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain

(2016) Nan Gu et al.   BRAIN BEHAVIOR AND IMMUNITY

Differential effects of stress on microglial cell activation in male and female medial prefrontal cortex

(2016) Justin L. Bollinger et al.   BRAIN BEHAVIOR AND IMMUNITY

Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress

(2016) Giampaolo Milior et al.   BRAIN BEHAVIOR AND IMMUNITY

Got worms? Perinatal exposure to helminths prevents persistent immune sensitization and cognitive dysfunction induced by early-life infection

(2016) Lauren L. Williamson et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuro-immune dysfunction during brain aging: new insights in microglial cell regulation

(2016) Stephanie M Matt et al.   CURRENT OPINION IN PHARMACOLOGY

Dark microglia: A new phenotype predominantly associated with pathological states

(2016) Kanchan Bisht et al.   GLIA

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina

(2016) E. G. O’Koren et al.   Scientific Reports

Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish

(2015) Jin Xu et al.   DEVELOPMENTAL CELL

miR-124Contributes to the functional maturity of microglia

(2015) Adam J. Svahn et al.   Developmental Neurobiology

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

(2015) T. Goldmann et al.   EMBO JOURNAL

Transient activation of microglia following acute alcohol exposure in developing mouse neocortex is primarily driven by BAX-dependent neurodegeneration

(2015) Katelin E. Ahlers et al.   GLIA

Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells

(2015) Jianpeng Sheng et al.   IMMUNITY

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Microglial numbers attain adult levels after undergoing a rapid decrease in cell number in the third postnatal week

(2015) Maria Nikodemova et al.   JOURNAL OF NEUROIMMUNOLOGY

Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus

(2015) R. A. Rice et al.   JOURNAL OF NEUROSCIENCE

A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone

(2015) A. L. Ribeiro Xavier et al.   JOURNAL OF NEUROSCIENCE

Modulation of Microglial Process Convergence Toward Neuronal Dendrites by Extracellular Calcium

(2015) U. B. Eyo et al.   JOURNAL OF NEUROSCIENCE

Selective Activation of Microglia Facilitates Synaptic Strength

(2015) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

Wild-type microglia do not reverse pathology in mouse models of Rett syndrome

(2015) Jieqi Wang et al.   NATURE

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Go with your gut: microbiota meet microglia

(2015) Kira Irving Mosher et al.   NATURE NEUROSCIENCE

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Microglia recapitulate a hematopoietic master regulator network in the aging human frontal cortex

(2015) Claudia C. Wehrspaun et al.   NEUROBIOLOGY OF AGING

Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia

(2015) Ruth M. Barrientos et al.   NEUROBIOLOGY OF AGING

Neuroinflammation in the normal aging hippocampus

(2015) R.M. Barrientos et al.   NEUROSCIENCE

Microglia: Dynamic Mediators of Synapse Development and Plasticity

(2015) Yuwen Wu et al.   TRENDS IN IMMUNOLOGY

Brain region-specific gene expression profiles in freshly isolated rat microglia

(2015) Karlijn J. Doorn et al.   Frontiers in Cellular Neuroscience

Origin of Microglia: Current Concepts and Past Controversies

(2015) Florent Ginhoux et al.   Cold Spring Harbor Perspectives in Biology

Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures

(2015) Sabine Hellwig et al.   Scientific Reports

Impact of age-related neuroglial cell responses on hippocampal deterioration

(2015) Joseph O. Ojo et al.   Frontiers in Aging Neuroscience

Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity

(2015) Nathalie Castanon et al.   Frontiers in Neuroscience

The role of microglia in human disease: therapeutic tool or target?

(2014) Nathalie Cartier et al.   ACTA NEUROPATHOLOGICA

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

What is microglia neurotoxicity (Not)?

(2014) Knut Biber et al.   GLIA

Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease

(2014) Diego Gómez-Nicola et al.   GLIA

Genetic targeting of microglia

(2014) Peter Wieghofer et al.   GLIA

Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis

(2014) Marcus Karlstetter et al.   Journal of Neuroinflammation

Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone

(2014) Y. Shigemoto-Mogami et al.   JOURNAL OF NEUROSCIENCE

Macroglia-Microglia Interactions via TSPO Signaling Regulates Microglial Activation in the Mouse Retina

(2014) M. Wang et al.   JOURNAL OF NEUROSCIENCE

Activation of Neuronal NMDA Receptors Triggers Transient ATP-Mediated Microglial Process Outgrowth

(2014) L. Dissing-Olesen et al.   JOURNAL OF NEUROSCIENCE

Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus

(2014) U. B. Eyo et al.   JOURNAL OF NEUROSCIENCE

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Maternal immune activation and abnormal brain development across CNS disorders

(2014) Irene Knuesel et al.   Nature Reviews Neurology

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Fractalkine regulation of microglial physiology and consequences on the brain and behavior

(2014) Rosa Chiara Paolicelli et al.   Frontiers in Cellular Neuroscience

Microglia change from a reactive to an age-like phenotype with the time in culture

(2014) Cláudia Caldeira et al.   Frontiers in Cellular Neuroscience

Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex

(2014) Benedetta Arnò et al.   Nature Communications

Microglia Modulate Wiring of the Embryonic Forebrain

(2014) Paola Squarzoni et al.   Cell Reports

Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis

(2014) Amanda Sierra et al.   NEURAL PLASTICITY

Homeostatic and injury-induced microglia behavior in the aging brain

(2013) Jasmin K. Hefendehl et al.   AGING CELL

Re-establishment of Anxiety in Stress-Sensitized Mice Is Caused by Monocyte Trafficking from the Spleen to the Brain

(2013) Eric S. Wohleb et al.   BIOLOGICAL PSYCHIATRY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Adaptive phenotype of microglial cells during the normal postnatal development of the somatosensory “Barrel” cortex

(2013) Isabelle Arnoux et al.   GLIA

Frank A. Beach Award: Programming of neuroendocrine function by early-life experience: A critical role for the immune system

(2013) Staci D. Bilbo   HORMONES AND BEHAVIOR

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

(2013) Ravid Shechter et al.   IMMUNITY

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

(2013) C. L. Cunningham et al.   JOURNAL OF NEUROSCIENCE

Microglia Are Essential to Masculinization of Brain and Behavior

(2013) K. M. Lenz et al.   JOURNAL OF NEUROSCIENCE

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

(2013) T Kreisel et al.   MOLECULAR PSYCHIATRY

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

(2013) Allison R Bialas et al.   NATURE NEUROSCIENCE

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Neuroinflammation in healthy aging: A PET study using a novel Translocator Protein 18kDa (TSPO) radioligand, [18F]-FEPPA

(2013) I. Suridjan et al.   NEUROIMAGE

Microglia: Scapegoat, Saboteur, or Something Else?

(2013) A. Aguzzi et al.   SCIENCE

Microglial control of neuronal activity

(2013) Catherine Béchade et al.   Frontiers in Cellular Neuroscience

Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation

(2013) Wai T. Wong   Frontiers in Cellular Neuroscience

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

Site-Specific Distribution of CD68-Positive Microglial Cells in the Brains of Human Midterm Fetuses: A Topographical Relationship with Growing Axons

(2013) Kwang Ho Cho et al.   Biomed Research International

Microglia: An Active Player in the Regulation of Synaptic Activity

(2013) Kyungmin Ji et al.   NEURAL PLASTICITY

Microglia and Synapse: Interactions in Health and Neurodegeneration

(2013) Zuzana Šišková et al.   NEURAL PLASTICITY

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

(2012) Ying Li et al.   DEVELOPMENTAL CELL

TGF-β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment

(2012) Shai Abutbul et al.   GLIA

Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices

(2012) Marie-Ève Tremblay et al.   GLIA

Regulation of microglia development and homeostasis

(2012) Melanie Greter et al.   GLIA

Microglia and neurodegeneration: The role of systemic inflammation

(2012) Colm Cunningham   GLIA

Complex invasion pattern of the cerebral cortex bymicroglial cells during development of the mouse embryo

(2012) Nina Swinnen et al.   GLIA

Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

(2012) Melanie Greter et al.   IMMUNITY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

(2012) Oleg Butovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

(2012) Guillaume Hoeffel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Postnatal Forebrain Amoeboid Microglial Cell Proliferation and Development by the Transcription Factor Runx1

(2012) M. Zusso et al.   JOURNAL OF NEUROSCIENCE

Microglia Proliferation Is Controlled by P2X7 Receptors in a Pannexin-1-Independent Manner during Early Embryonic Spinal Cord Invasion

(2012) C. Rigato et al.   JOURNAL OF NEUROSCIENCE

Deficiency of the Microglial Receptor CX3CR1 Impairs Postnatal Functional Development of Thalamocortical Synapses in the Barrel Cortex

(2012) M. Hoshiko et al.   JOURNAL OF NEUROSCIENCE

Wild-type microglia arrest pathology in a mouse model of Rett syndrome

(2012) Noël C. Derecki et al.   NATURE

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

IFN Regulatory Factor 8 Is a Key Constitutive Determinant of the Morphological and Molecular Properties of Microglia in the CNS

(2012) Carsten Minten et al.   PLoS One

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Evidence that Microglia Mediate the Neurobiological Effects of Chronic Psychological Stress on the Medial Prefrontal Cortex

(2011) M. Hinwood et al.   CEREBRAL CORTEX

Long Term Potentiation Is Impaired in Membrane Glycoprotein CD200-deficient Mice

(2011) Derek A. Costello et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Fractalkine Receptor but Not CCR2 Is Present on Microglia from Embryonic Development throughout Adulthood

(2011) M. Mizutani et al.   JOURNAL OF IMMUNOLOGY

Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment

(2011) Heather D VanGuilder et al.   Journal of Neuroinflammation

The Role of Microglia in the Healthy Brain

(2011) M.-E. Tremblay et al.   JOURNAL OF NEUROSCIENCE

CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity

(2011) J. T. Rogers et al.   JOURNAL OF NEUROSCIENCE

A role for glia in the progression of Rett’s syndrome

(2011) Daniel T. Lioy et al.   NATURE

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Microglial Morphology and Dynamic Behavior Is Regulated by Ionotropic Glutamatergic and GABAergic Neurotransmission

(2011) Aurora M. Fontainhas et al.   PLoS One

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

The initiation of blood flow and flow induced events in early vascular development

(2011) Elizabeth A.V. Jones   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

CX3CR1 deficiency alters hippocampal-dependent plasticity phenomena blunting the effects of enriched environment

(2011) Laura Maggi   Frontiers in Cellular Neuroscience

Age-related alterations in the dynamic behavior of microglia

(2010) Mausam R. Damani et al.   AGING CELL

Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice

(2010) Shau-Kwaun Chen et al.   CELL

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

Microglia in the developing brain: from immunity to behaviour

(2010) Timm Schlegelmilch et al.   CURRENT OPINION IN NEUROBIOLOGY

Rett Syndrome Microglia Damage Dendrites and Synapses by the Elevated Release of Glutamate

(2010) I. Maezawa et al.   JOURNAL OF NEUROSCIENCE

Microglia in the aging brain: relevance to neurodegeneration

(2010) Xiao-Guang Luo et al.   Molecular Neurodegeneration

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

Microglial activation in healthy aging

(2010) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

Dual Roles for Perivascular Macrophages in Immune-to-Brain Signaling

(2010) Jordi Serrats et al.   NEURON

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R)

(2009) Laura Maggi et al.   JOURNAL OF NEUROIMMUNOLOGY

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin

(2009) Karel Otero et al.   NATURE IMMUNOLOGY

Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

(2009) N. Cartier et al.   SCIENCE

Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo

(2008) Francesca Peri et al.   CELL

Glial responses, neuron death and lesion resolution after intracerebral hemorrhage in young vs. aged rats

(2008) Jason K. Wasserman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Steroid hormone receptor expression and function in microglia

(2008) Amanda Sierra et al.   GLIA

Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS

(2008) Alexander H. de Haas et al.   GLIA

Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system

(2008) Ryan N. Dilger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Prenatal Activation of Microglia Induces Delayed Impairment of Glutamatergic Synaptic Function

(2008) Anne Roumier et al.   PLoS One

Three-Dimensional Analysis of Vascular Development in the Mouse Embryo

(2008) Johnathon R. Walls et al.   PLoS One