Article
Cardiac & Cardiovascular Systems
Alan J. Mouton, Elizabeth R. Flynn, Sydney P. Moak, Xuan Li, Alexandre A. da Silva, Zhen Wang, Jussara M. do Carmo, Michael E. Hall, John E. Hall
Summary: Obesity alone does not cause cardiac injury or exacerbate hypertension-induced cardiac dysfunction. After MI, obese-normotensive mice had lower survival rates compared with chow-fed mice, and this was further decreased by hypertension. Surviving obese-normotensive mice displayed improved post-MI cardiac function and metabolism, while these favorable changes were attenuated by hypertension when it accompanied obesity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Athira Anilkumar Sudharma, Sivaramakrishna Siginam, Gulam M. Husain, Surekha Venkata Mullapudi, Ayesha Ismail
Summary: Vitamin D deficiency leads to cardiac atrophy and dysfunction, characterized by cardiac arrhythmia, decreased heart weight, increased apoptosis, and interstitial fibrosis. It reduces protein synthesis and increases protein degradation through the activation of proteolytic systems while suppressing the mTOR pathway. This results in decreased expression of myosin heavy chain and troponin genes, as well as decreased activities of metabolic enzymes. The heart responds to VDD by activating all three proteolytic systems.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Nutrition & Dietetics
Lucia Melguizo-Rodriguez, Victor J. Costela-Ruiz, Enrique Garcia-Recio, Elvira De Luna-Bertos, Concepcion Ruiz, Rebeca Illescas-Montes
Summary: The prevalence of hypovitaminosis D has been increasing in developed countries due to lifestyle changes and unhealthy habits. Scientific evidence shows an inverse relationship between vitamin D deficiency and metabolic syndrome (MetS), with supplementation helping improve outcomes in individuals with MetS. Maintaining optimal vitamin D concentrations is proposed as a preventive strategy against MetS.
Review
Oncology
Mingzhou Jiang, Xi Fan, Yiqing Wang, Xiaotian Sun
Summary: Oxygen is essential for cardiomyocyte metabolism, and hypoxia may lead to metabolic remodeling and heart failure. Hypoxia-inducible factors (HIFs) are implicated in regulating hypoxia-induced metabolic changes and have potential therapeutic implications for heart failure. Understanding the effects of hypoxic pathways on heart failure can provide new treatment options.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Prachi Umbarkar, Anand P. Singh, Sultan Tousif, Qinkun Zhang, Palaniappan Sethu, Hind Lal
Summary: Nintedanib (NTB) is an FDA-approved tyrosine kinase inhibitor for pulmonary fibrosis, and study shows its potential in reducing cardiac fibrosis and improving cardiac function in a murine heart failure model, suggesting its promising application in treating HF patients.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Emilie Dubois-Deruy, Yara El Masri, Annie Turkieh, Philippe Amouyel, Florence Pinet, Jean-Sebastien Annicotte
Summary: Lysine acetylation is a conserved mechanism that affects various biological processes, and its dysregulation is associated with cardiac dysfunction. This review summarizes the regulation of cardiac acetylation and its roles in both physiological and pathological conditions, highlighting its importance in cardiovascular diseases and suggesting KATs and KDACs as potential therapeutic targets for heart failure.
Article
Cardiac & Cardiovascular Systems
Yijun Yang, Justin Kurian, Giana Schena, Jaslyn Johnson, Hajime Kubo, Joshua G. Travers, Chunya Kang, Anna Maria Lucchese, Deborah M. Eaton, Maoting Lv, Na Li, Lorianna G. Leynes, Daohai Yu, Fengzhen Yang, Timothy A. McKinsey, Raj Kishore, Mohsin Khan, Sadia Mohsin, Steven R. Houser
Summary: The study suggests that metabolic syndrome in obese pregnant women may lead to pathological cardiac remodeling, increasing the risk of chronic heart disorders.
Article
Cardiac & Cardiovascular Systems
Alberto Preda, Luca Liberale, Fabrizio Montecucco
Summary: Metabolic syndrome (MetS) leads to cardiovascular disease and diabetes, often resulting in adverse cardiac remodeling and myocardial dysfunction. Factors such as altered cardiomyocyte function, increased neurohormonal tone, and interstitial fibrosis are implicated in the development of adverse cardiac remodeling. Early detection and optimal treatment strategies are crucial in preventing progression to symptomatic phase.
HEART FAILURE REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Xiaonan Sun, Jalen Alford, Hongyu Qiu
Summary: Mitochondrial remodeling is crucial for maintaining normal cellular function and dysregulation can lead to complex diseases. Understanding the molecular basis and regulatory network of mitochondrial remodeling is important for elucidating the pathogenesis of cardiac diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Danilo Martins, Leonardo Rufino Garcia, Diego Aparecido Rios Queiroz, Taline Lazzarin, Carolina Rodrigues Tonon, Paola da Silva Balin, Bertha Furlan Polegato, Sergio Alberto Rupp de Paiva, Paula Schmidt Azevedo, Marcos Ferreira Minicucci, Leonardo Zornoff
Summary: Cardiac remodeling refers to a series of molecular, cellular, and interstitial changes in the heart that occur after different stimuli, manifesting clinically as changes in size, mass, geometry, and function. Remodeling plays a crucial pathophysiological role in the onset and progression of ventricular dysfunction. The role of oxidative stress as a therapeutic target for cardiac remodeling has been gaining attention in recent years.
Article
Food Science & Technology
Chaohua Tang, Shuang Li, Kai Zhang, Jing Li, Yunsheng Han, Qingyu Zhao, Xiaoqing Guo, Yuchang Qin, Jingdong Yin, Junmin Zhang
Summary: A study using a pig model investigates the effects of selenium deficiency on the heart. The study reveals that selenium deficiency leads to cardiac oxidative stress, disordered energy production, lipid metabolic vulnerabilities, and inflammation initiation pathways. These findings provide potential targets for treating cardiac diseases induced by redox imbalance.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Endocrinology & Metabolism
Peizhen Zhang, Dan Guo, Bingyan Xu, Chensihan Huang, Shunyu Yang, Weiwei Wang, Wenhui Liu, Yajuan Deng, Kangli Li, Deying Liu, Jiayang Lin, Xueyun Wei, Yan Huang, Huijie Zhang
Summary: This study highlights the importance of monitoring and correcting vitamin D deficiency in the prevention of cardiovascular disease (CVD) and mortality among individuals with prediabetes and diabetes.
Article
Cardiac & Cardiovascular Systems
Hongmei Zhao, Hongqin Yang, Chi Geng, Yang Chen, Junling Pang, Ting Shu, Meijun Zhao, Yaqin Tang, Zhiwei Li, Baicun Li, Cuiliu Hou, Xiaomin Song, Aoxue Wu, Xiaoxiao Guo, Si Chen, Bin Liu, Chen Yan, Jing Wang
Summary: The study found that IgE plays a causative role in pathological cardiac remodeling, at least partially through activating IgE-Fc epsilon R1 signaling in cardiomyocytes and cardiac fibroblasts. Therapeutic strategies targeting the IgE-Fc epsilon R1 axis may be effective for managing IgE-mediated cardiac remodeling.
Review
Biology
Asmaa Carla Hagau, Amalia Puscas, Rodica Toganel, Iolanda Muntean
Summary: Recent studies have shown a link between vitamin D levels and heart failure. Vitamin D deficiency is associated with increased cardiovascular morbidity and mortality, as well as a higher risk of developing heart failure. This systematic review aimed to analyze recent studies on the relationship between vitamin D deficiency and heart failure in adult and pediatric populations.
Review
Endocrinology & Metabolism
Zahra Hajhashemy, Farnaz Shahdadian, Elham Moslemi, Fateme Sadat Mirenayat, Parvane Saneei
Summary: The systematic review and meta-analysis showed an inverse association between serum vitamin D levels and risk of metabolic syndrome in adults, with higher vitamin D levels associated with decreased odds of MetS. However, prospective studies did not show a significant relation, indicating a need for further research to confirm causality.
Article
Pharmacology & Pharmacy
Yogesh Kumar, Kaushik Kuche, Rajan Swami, Sameer S. Katiyar, Dasharath Chaudhari, Parmeshwar B. Katare, Sanjay K. Banerjee, Sanyog Jain
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Cell Biology
Sima Kumari, Parmeshwar B. Katare, R. Elancheran, Hina L. Nizami, Bugga Paramesha, Sudheer Arava, Partha Pratim Sarma, Roshan Kumar, Dinesh Mahajan, Yashwant Kumar, Rajlakshmi Devi, Sanjay K. Banerjee
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Chemistry, Organic
Ramesh Mukkamala, Roshan Kumar, Sanjay K. Banerjee, Indrapal Singh Aidhen
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Genetics & Heredity
Suruchi Aggarwal, Sanjay K. Banerjee, Narayan Chandra Talukdar, Amit Kumar Yadav
FRONTIERS IN GENETICS
(2020)
Review
Pharmacology & Pharmacy
Sanjay Kumar Dey, Manisha Saini, Pankaj Prabhakar, Suman Kundu
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2020)
Article
Medicine, Research & Experimental
Ramesh Chandra Rai, Pankaj K. Bagul, Sanjay Kumar Banerjee
Article
Cell Biology
Soheb Anwar Mohammed, Bugga Paramesha, Yashwant Kumar, Ubaid Tariq, Sudheer Kumar Arava, Sanjay Kumar Banerjee
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Review
Pharmacology & Pharmacy
Ubaid Tariq, Shravan K. Uppulapu, Sanjay K. Banerjee
Summary: Glycogen synthase kinase 3 (GSK-3) is a widely expressed serine/threonine kinase that plays a crucial role in regulating various cellular processes, especially in cardiac biology. While its inhibition can promote cardiomyocyte proliferation and cardiac regeneration, it may also lead to hypertrophic myopathy. Therefore, GSK-3 inhibitors are considered a double-edged sword due to their beneficial and off-target effects in heart disease treatment.
CURRENT DRUG TARGETS
(2021)
Review
Pharmacology & Pharmacy
Pankaj Prabhakar, Giriyapura Srikantachar Pavankumar, Shamprasad Varija Raghu, Suresh Rao, Krishna Prasad, Thomas George, Manjeshwar Shrinath Baliga
Summary: The World Health Organization predicts a 70% increase in cancer incidents in developing nations over the next decade, making it the second leading cause of death worldwide. Traditional plant-based medicine systems, particularly indigenous fruits in India, have shown beneficial effects in preventing and treating cancer. These fruits are non-toxic, easily accepted, and have been a part of the diet in India for a long time.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Materials Science, Multidisciplinary
Hadi Ebrahimi-Darkhaneh, Zeshaan Shamsi, Martin G. R. Banda, Manuel Quevedo-Lopez, Luigi Colombo, Sanjay K. Banerjee
Summary: This article proposes a novel design approach for lateral Schottky barrier diodes using a wide bandgap oxide semiconductor on silicon. The fabricated device's structural and electrical properties are reported and compared. Due to the low-temperature process, simplicity of fabrication steps, and high figure-of-merit, the proposed diode shows great potential for power electronics applications.
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2022)
Article
Cell Biology
Hina L. Nizami, Parmeshwar B. Katare, Pankaj Prabhakar, Ramu Adela, Soumalya Sarkar, Sudheer Arava, Praloy Chakraborty, Subir K. Maulik, Sanjay K. Banerjee
Summary: The study demonstrates that paricalcitol can reverse cardiac dysfunction in rats with metabolic syndrome by enhancing mitochondrial fusion.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Navya Malladi, Md Jahangir Alam, Subir K. Maulik, Sanjay K. Banerjee
Summary: Platelets play a crucial role in thrombosis and the progression of many diseases. In non-alcoholic fatty liver disease (NAFLD), platelets are highly activated and contribute to disease progression by promoting a pro-thrombotic and pro-inflammatory state. Various platelet parameters have been found to be associated with NAFLD. Furthermore, platelets are involved in the development of cardiovascular complications in NAFLD. Modulating platelet function using medications like aspirin, ticlopidine, and cilostazol has shown potential in controlling NAFLD progression. Future research should focus on antiplatelet therapy to control platelet activation and reduce cardiovascular risk in NAFLD.
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2023)