Review
Neurosciences
Sean L. Johnson, Wei-Ling Tsou, Matthew V. Prifti, Autumn L. Harris, Sokol V. Todi
Summary: The presence and aggregation of misfolded proteins have harmful effects on the nervous system, specifically in the family of polyglutamine (polyQ) disorders. These disorders are caused by the abnormal elongation of a polyQ repeat in different proteins, leading to misfolding, aggregation, cellular dysfunction, and diseases. However, each disease is distinct due to the surrounding regions, interacting proteins, and posttranslational modifications. This overview focuses on the control of pathogenicity in the expanded polyQ repeat by non-polyQ regions and explores shared processes and therapeutic entry points for these incurable disorders.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Chemistry, Analytical
Xin Wang, Wenxiu Zhou, Zhenye Gao, Xiaoyuan Lv
Summary: This review summarizes the application of mass spectrometry techniques in the analysis of protein S-nitrosylation, including sample preparation techniques and qualitative and quantitative strategies. The roles of protein S-nitrosylation in human diseases are discussed, with an emphasis on current limitations and future research directions.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Genetics & Heredity
Anna Schmuecker, Bingkun Lei, Zdravko J. Lorkovic, Matias Capella, Sigurd Braun, Pierre Bourguet, Olivier Mathieu, Karl Mechtler, Frederic Berger
Summary: The selection of C-terminal motifs contributes to the evolution of distinct histone H2A variants, with cell cycle dependent kinases playing a crucial role. Interference between the functions carried by these motifs led to their mutual exclusion and the evolution of different classes of H2A variants.
Review
Biochemistry & Molecular Biology
Laura Ghezzi, Claudia Cantoni, Emanuela Rotondo, Daniela Galimberti
Summary: The gut-brain axis (GBA) is a complex network that connects the gut and the brain through bidirectional communication. The gut microbiome plays a crucial role in the GBA and its alterations have been associated with GBA dysfunction, CNS inflammation, and degeneration. Small clinical and preclinical trials have shown promising outcomes by manipulating the microbial composition, but larger randomized control trials are needed.
Review
Pharmacology & Pharmacy
Xingru Yang, Xianjing Song, Zhibo Li, Ning Liu, Youyou Yan, Bin Liu
Summary: Extracellular vesicles are crucial carriers of biological information between cells in the diagnosis and treatment of cardiovascular diseases, with their biogenesis closely linked to autophagy. There is significant crosstalk between extracellular vesicles and autophagy, playing important roles in cardiovascular pathophysiology.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cell Biology
Rehab F. F. Abdelhamid, Seiichi Nagano
Summary: The global population is aging rapidly, leading to an increased burden of age-related health issues. On the other hand, premature aging has become a problem with younger individuals experiencing aging-related symptoms. Advanced aging is influenced by various factors including lifestyle, diet, external and internal factors, as well as oxidative stress (OS). OS not only contributes to aging but also plays a significant role in neurodegenerative diseases such as ALS, FTD, AD, and PD. This review focuses on discussing the relationship between aging and OS, the impact of OS on neurodegenerative disorders, and potential therapeutic approaches to alleviate neurodegenerative symptoms associated with pro-oxidative conditions.
Review
Biology
Koyo Harada, Simon M. Carr, Amit Shrestha, Nicholas B. La Thangue
Summary: Post-translational modifications play a crucial role in disease pathogenesis and progression. Protein arginine citrullination, a type of modification catalyzed by peptidylarginine deiminases (PADs), is emerging as a potential therapeutic target in cancer. This review discusses the functions of PADs in cancer biology and their interplay with other types of modifications, shedding light on downstream biological events.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Cell Biology
Suqi Wu, Ketong Liu, Bingyan Zhou, Suwen Wu
Summary: Placenta, as a medium connecting pregnant women, environment, and fetus, plays a crucial role in regulating gene expression and maintaining cellular homeostasis through powerful and delicate epigenetic processes. N6-methyladenosine (m(6)A), the most prevalent RNA modification, shows dynamic reversibility and sensitivity to environmental stimuli, suggesting its significance in placental development and maternal-fetal crosstalk. Disturbance in proper m(6)A modifications due to environmental factors can lead to abnormal placentation, compromised function, and potential consequences of gestational diseases, fetal growth, and adult disease susceptibility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Songzhe He, Fushun Wang, Ken Kin Lam Yung, Shiqing Zhang, Shaogang Qu
Summary: This review summarizes the structure, physiological function, and effects of post-translational modifications on alpha-syn aggregation, which may elucidate mechanisms for Parkinson's disease pathogenesis and lay a theoretical foundation for clinical treatment.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Ana Rita de Oliveira dos Santos, Barbara de Oliveira Zanuso, Vitor Fernando Bordin Miola, Sandra Maria Barbalho, Patricia C. Santos Bueno, Uri Adrian Prync Flato, Claudia Rucco P. Detregiachi, Daniela Vieira Buchaim, Rogerio Leone Buchaim, Ricardo Jose Tofano, Claudemir Gregorio Mendes, Viviane Alessandra Capelluppi Tofano, Jesselina F. dos Santos Haber
Summary: Adipokines, myokines, and hepatokines are endocrine markers produced by adipose, skeletal, and hepatic muscle tissues, respectively, which can have harmful or beneficial effects on an organism. The interactions between these markers in the body can contribute to the development of various physiological disorders, such as type 2 diabetes, obesity, metabolic syndrome, and cardiovascular diseases. The understanding of these interactions may provide insights into potential therapeutic targets for diagnosing and treating metabolic syndrome and cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Natalia Ogonowski, Hernando Santamaria-Garcia, Sandra Baez, Andrea Lopez, Andres Laserna, Elkin Garcia-Cifuentes, Paola Ayala-Ramirez, Ignacio Zarante, Fernando Suarez-Obando, Pablo Reyes, Marcelo Kauffman, Nick Cochran, Michael Schulte, Daniel W. Sirkis, Salvatore Spina, Jennifer S. Yokoyama, Bruce L. Miller, Kenneth S. Kosik, Diana Matallana, Agustin Ibanez
Summary: In this study, three unrelated families with frontotemporal dementia (FTD) and the heterozygous p.H157Y variant of TREM2 were reported. The patients showed early behavioral changes, greater impairments in general cognition and executive function, and brain atrophy in FTD characteristic areas. The results provide the first evidence of an FTD presentation potentially associated with the p.H157Y variant with exacerbated neurocognitive impairments.
JOURNAL OF MEDICAL GENETICS
(2023)
Review
Pharmacology & Pharmacy
Tian Zhang, Shuai Guo, Fangzhou Li, Xinmiao Lan, Yaru Jia, Jinchao Zhang, Yuanyu Huang, Xing-Jie Liang
Summary: This review emphasizes the importance of timely and accurate assessment and diagnosis for various diseases, introduces the application of molecular imaging technology in disease diagnosis and treatment, and aims to promote the development of related technologies and fields.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Xiaoxiao Zhang, Jiaming Zhang, Yuchuan Wang, Minji Wang, Man Tang, Yuhan Lin, Qiuyun Liu
Summary: Methylations in living cells involve methyl groups attached to various molecules, potentially leading to changes in chemical bonds and interactions with other compounds. These modifications could play a role in the pathogenesis of neurodegenerative diseases by affecting the structure and function of molecules in cells.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Nutrition & Dietetics
Umair Shabbir, Muhammad Sajid Arshad, Aysha Sameen, Deog-Hwan Oh
Summary: The gut microbiota can influence brain immune homeostasis through the microbiota-gut-brain axis and play a key role in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Modulating GM through diet, probiotics, or fecal microbiota transplantation may represent potential therapeutic strategies in treating AD.
Review
Immunology
Yinwei Chen, Jinghua Zhou, Li Wang
Summary: The human gut microbiome plays a crucial role in human health, and dysbiosis may lead to various chronic diseases. The mechanisms of its impact on neurodegenerative diseases, cardiovascular diseases, metabolic diseases, and gastrointestinal diseases are extremely complex.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Chemistry, Organic
Ramesh Mukkamala, Roshan Kumar, Sanjay K. Banerjee, Indrapal Singh Aidhen
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Medicine, Research & Experimental
Ramesh Chandra Rai, Pankaj K. Bagul, Sanjay Kumar Banerjee
Review
Pharmacology & Pharmacy
Ubaid Tariq, Shravan K. Uppulapu, Sanjay K. Banerjee
Summary: Glycogen synthase kinase 3 (GSK-3) is a widely expressed serine/threonine kinase that plays a crucial role in regulating various cellular processes, especially in cardiac biology. While its inhibition can promote cardiomyocyte proliferation and cardiac regeneration, it may also lead to hypertrophic myopathy. Therefore, GSK-3 inhibitors are considered a double-edged sword due to their beneficial and off-target effects in heart disease treatment.
CURRENT DRUG TARGETS
(2021)
Article
Biotechnology & Applied Microbiology
Kiran Bala Sharma, Simran Chhabra, Suruchi Aggarwal, Aarti Tripathi, Arup Banerjee, Amit Kumar Yadav, Sudhanshu Vrati, Manjula Kalia
Summary: Advances in proteomics have provided a comprehensive understanding of host-pathogen interactions, with a specific focus on Japanese encephalitis virus (JEV) infection-driven changes in mouse embryonic fibroblast (MEF) proteomes. The study identified alterations in innate immune sensing, interferon responses, inflammation, and other biological pathways in response to JEV infection. Functional validation demonstrated the crucial role of anti-viral innate immune proteins in restricting viral replication and the impact of TLR2 signaling in modulating inflammatory cytokine production. Additionally, the study revealed significant downregulation of proteins related to cell adhesion, transport, and lipid biosynthesis in infected cells.
JOURNAL OF GENERAL VIROLOGY
(2021)
Article
Biology
Manish Pandey, Sakshi Bansal, Sudipta Bar, Amit Kumar Yadav, Nicholas S. Sokol, Jason M. Tennessen, Pankaj Kapahi, Geetanjali Chawla
Summary: In fruit flies, two neuronally enriched and highly conserved microRNAs, miR-125 and let-7, have been shown to mediate the response to dietary restriction (DR) that extends lifespan. MiR-125 functions in neurons, while its target gene chinmo modulates fat metabolism and longevity in both neurons and the fat body. Chinmo exerts its DR effects by regulating the expression of several proteins, indicating a potential avenue for miR-125 and its downstream effectors as drug candidates for late-onset diseases and biomarkers for healthy aging in humans.
Article
Biology
Zaigham Abbas Rizvi, Rajdeep Dalal, Srikanth Sadhu, Akshay Binayke, Jyotsna Dandotiya, Yashwant Kumar, Tripti Shrivastava, Sonu Kumar Gupta, Suruchi Aggarwal, Manas Ranjan Tripathy, Deepak Kumar Rathore, Amit Kumar Yadav, Guruprasad R. Medigeshi, Amit Kumar Pandey, Sweety Samal, Shailendra Asthana, Amit Awasthi
Summary: Using a hamster model, researchers found that early SARS-CoV-2 infection leads to acute inflammatory response and lung pathology, while late-stage infection causes cardiovascular complications characterized by ventricular wall thickening and interstitial coronary fibrosis. Molecular profiling showed elevated levels of cardiac troponin I, cholesterol, low-density lipoprotein, and long-chain fatty acid triglycerides in the infected hamsters' serum. Metabolomics profiling identified N-acetylneuraminate as a common metabolic marker between infected hamsters and COVID-19 patients. The study suggests that hamsters are a suitable animal model for studying cardiovascular complications associated with post-COVID sequelae.
Review
Biochemical Research Methods
Suruchi Aggarwal, Anurag Raj, Dhirendra Kumar, Debasis Dash, Amit Kumar Yadav
Summary: Proteogenomics integrates genome and proteome analysis to improve genome annotation and discover new insights by controlling error rates. However, challenges arise due to database size inflation, leading to reduced sensitivity and specificity in proteogenomic studies. Understanding key factors and applying modified strategies can enhance interpretation of mass spectrometry data and effectively manage false positives and negatives.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Materials Science, Multidisciplinary
Hadi Ebrahimi-Darkhaneh, Zeshaan Shamsi, Martin G. R. Banda, Manuel Quevedo-Lopez, Luigi Colombo, Sanjay K. Banerjee
Summary: This article proposes a novel design approach for lateral Schottky barrier diodes using a wide bandgap oxide semiconductor on silicon. The fabricated device's structural and electrical properties are reported and compared. Due to the low-temperature process, simplicity of fabrication steps, and high figure-of-merit, the proposed diode shows great potential for power electronics applications.
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2022)
Editorial Material
Genetics & Heredity
Amit Kumar Yadav, Sanjay Kumar Banerjee, Bhabatosh Das, Kumardeep Chaudhary
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Hina L. Nizami, Parmeshwar B. Katare, Pankaj Prabhakar, Ramu Adela, Soumalya Sarkar, Sudheer Arava, Praloy Chakraborty, Subir K. Maulik, Sanjay K. Banerjee
Summary: The study demonstrates that paricalcitol can reverse cardiac dysfunction in rats with metabolic syndrome by enhancing mitochondrial fusion.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Letter
Oncology
Aleksha Panwar, Rinki Kumar, Renu Goel, Suruchi Aggarwal, Shweta Saraswat, Priyanka Bansal, Zaozianlungliu Gonmei, Gurudyal Toteja, Amit Yadav, Rakesh Lodha, Nirpendra Singh, Guruprasad Medigeshi
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Navya Malladi, Md Jahangir Alam, Subir K. Maulik, Sanjay K. Banerjee
Summary: Platelets play a crucial role in thrombosis and the progression of many diseases. In non-alcoholic fatty liver disease (NAFLD), platelets are highly activated and contribute to disease progression by promoting a pro-thrombotic and pro-inflammatory state. Various platelet parameters have been found to be associated with NAFLD. Furthermore, platelets are involved in the development of cardiovascular complications in NAFLD. Modulating platelet function using medications like aspirin, ticlopidine, and cilostazol has shown potential in controlling NAFLD progression. Future research should focus on antiplatelet therapy to control platelet activation and reduce cardiovascular risk in NAFLD.
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2023)