Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras

(2017) Ken Peeters et al.   Nature Communications

Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism

(2016) P. Lito et al.   SCIENCE

Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State

(2016) M. P. Patricelli et al.   Cancer Discovery

Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth

(2015) Lingtao Jin et al.   CANCER CELL

Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy

(2015) Bingshe Han et al.   CANCER CELL

Analysis of KRAS and NRAS Gene Mutations in Arab Asian Children With Acute Leukemia: High Frequency of RAS Mutations in Acute Lymphoblastic Leukemia

(2015) Lika'a Fasih Y. Al-Kzayer et al.   PEDIATRIC BLOOD & CANCER

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

(2015) J. Yun et al.   SCIENCE

Comparative analysis of KRAS codon 12, 13, 18, 61 and 117 mutations using human MCF10A isogenic cell lines

(2015) Britta Stolze et al.   Scientific Reports

A Novel Ras Inhibitor (MDC-1016) Reduces Human Pancreatic Tumor Growth in Mice

(2015) Gerardo G Mackenzie et al.   NEOPLASIA

Dragging Ras Back in the Ring

(2014) Andrew G. Stephen et al.   CANCER CELL

Small-molecule modulation of Ras signaling

(2014) Jochen Spiegel et al.   Nature Chemical Biology

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Small-molecule Bax agonists for cancer therapy

(2014) Meiguo Xin et al.   Nature Communications

LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

(2013) David B. Shackelford et al.   CANCER CELL

Novel Small-Molecule Inhibitors of Bcl-XL to Treat Lung Cancer

(2013) D. Park et al.   CANCER RESEARCH

Frequency of KRAS mutations in adult Korean patients with acute myeloid leukemia

(2013) Mi-Jung Park et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Prognostic value of K-RAS mutations in patients with non-small cell lung cancer: A systematic review with meta-analysis

(2013) Daquan Meng et al.   LUNG CANCER

Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer

(2013) S. You et al.   MOLECULAR CANCER THERAPEUTICS

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

(2013) Jonathan M. Ostrem et al.   NATURE

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

(2013) F. Shima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of Amino Acids in the Escherichia coli Octaprenyl Diphosphate Synthase Active Site Probed by Structure-Guided Site-Directed Mutagenesis

(2012) Keng-Ming Chang et al.   BIOCHEMISTRY

Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models

(2012) Ryan B. Corcoran et al.   CANCER CELL

Activating K-Ras mutations outwith ‘hotspot’ codons in sporadic colorectal tumours – implications for personalised cancer medicine

(2010) G Smith et al.   BRITISH JOURNAL OF CANCER

Somatic mutations of signaling genes in non-small-cell lung cancer

(2010) Heather R. Sanders et al.   CANCER GENETICS AND CYTOGENETICS

Genomic and Biological Characterization of Exon 4 KRAS Mutations in Human Cancer

(2010) M. Janakiraman et al.   CANCER RESEARCH

Death pathways triggered by activated Ras in cancer cells

(2010) Jean et al.   Frontiers in Bioscience-Landmark

Induction of Nonapoptotic Cell Death by Activated Ras Requires Inverse Regulation of Rac1 and Arf6

(2010) Haymanti Bhanot et al.   MOLECULAR CANCER RESEARCH

KRAS gene mutations in lung cancer: Particulars established and issues unresolved

(2010) Koji Okudela et al.   PATHOLOGY INTERNATIONAL

Active Ras Triggers Death in Glioblastoma Cells through Hyperstimulation of Macropinocytosis

(2008) J. H. Overmeyer et al.   MOLECULAR CANCER RESEARCH

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE