Cellular Senescence in the Kidney

Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells

(2019) Eliane Antonioli et al.   PLoS One

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

(2018) Athena Georgilis et al.   CANCER CELL

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

(2018) Akiko Takahashi et al.   Nature Communications

Metformin as geroprotector: experimental and clinical evidence

(2018) Veronika Piskovatska et al.   BIOGERONTOLOGY

Targeting of the C-Jun/BCL-XL/P21 Axis Accelerates the Switch from Senescence to Apoptosis Upon ROC1 Knockdown in Gastric Cancer Cells

(2018) Ping Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Aging, Cell Senescence, and Chronic Disease

(2018) Tamara Tchkonia et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Serum from patients with chronic obstructive pulmonary disease induces senescence-related phenotype in bronchial epithelial cells

(2018) Barbara Kuźnar-Kamińska et al.   Scientific Reports

F4/80+ Macrophages Contribute to Clearance of Senescent Cells in the Mouse Postpartum Uterus

(2017) Mahiro Egashira et al.   ENDOCRINOLOGY

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Calcitriol induces cell senescence of kidney cancer through JMJD3 mediated histone demethylation

(2017) Yongqing Shen et al.   Oncotarget

Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium

(2017) Paul J Brighton et al.   eLife

Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways

(2016) Lisa A. Lesniewski et al.   AGING CELL

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

(2016) Brian K. Kennedy et al.   Cell Metabolism

Conserved and novel functions of programmed cellular senescence during vertebrate development

(2016) Hongorzul Davaapil et al.   DEVELOPMENT

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

(2016) Marissa J. Schafer et al.   DIABETES

Renal Aging: Causes and Consequences

(2016) Eoin D. O’Sullivan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Questioning causal involvement of telomeres in aging

(2015) Mirre J.P. Simons   AGEING RESEARCH REVIEWS

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD

(2015) David A. Ferenbach et al.   Nature Reviews Nephrology

NK Cells of Kidney Transplant Recipients Display an Activated Phenotype that Is Influenced by Immunosuppression and Pathological Staging

(2015) Ulrike Hoffmann et al.   PLoS One

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-192 Induces G2/M Growth Arrest in Aristolochic Acid Nephropathy

(2014) Robert H. Jenkins et al.   AMERICAN JOURNAL OF PATHOLOGY

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice

(2014) Satomi Miwa et al.   Nature Communications

Immunosurveillance of senescent cells: the bright side of the senescence program

(2013) Adi Sagiv et al.   BIOGERONTOLOGY

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Senescence-associated protein p400 is a prognostic marker in renal cell carcinoma

(2013) STEPHAN MACHER-GOEPPINGER et al.   ONCOLOGY REPORTS

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer

(2012) C. M. Rudin et al.   CLINICAL CANCER RESEARCH

NF-κB inhibition delays DNA damage–induced senescence and aging in mice

(2012) Jeremy S. Tilstra et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular Senescence Limits Regenerative Capacity and Allograft Survival

(2012) H. Braun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Outcomes of Kidney Transplantation From Older Living Donors

(2012) Wai H. Lim et al.   TRANSPLANTATION

Donor Age-Specific Injury and Immune Responses

(2011) R. Oberhuber et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Phase I Study of Navitoclax (ABT-263), a Novel Bcl-2 Family Inhibitor, in Patients With Small-Cell Lung Cancer and Other Solid Tumors

(2011) Leena Gandhi et al.   JOURNAL OF CLINICAL ONCOLOGY

Cells Derived from Young Bone Marrow Alleviate Renal Aging

(2011) H.-C. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Accelerated senescence of renal tubular epithelial cells is associated with disease progression of patients with immunoglobulin A (IgA) nephropathy

(2011) Jun Liu et al.   Translational Research

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

WNT16B Is a New Marker of Cellular Senescence That Regulates p53 Activity and the Phosphoinositide 3-Kinase/AKT Pathway

(2009) R. Binet et al.   CANCER RESEARCH

Physical Exercise Prevents Cellular Senescence in Circulating Leukocytes and in the Vessel Wall

(2009) Christian Werner et al.   CIRCULATION

Cellular senescence in pretransplant renal biopsies predicts postoperative organ function

(2008) Liane M. McGlynn et al.   AGING CELL

Disparate Effects of Roscovitine on Renal Tubular Epithelial Cell Apoptosis and Senescence: Implications for Autosomal Dominant Polycystic Kidney Disease

(2008) Jin-Young Park et al.   AMERICAN JOURNAL OF NEPHROLOGY

Effects of Donor Age and Cell Senescence on Kidney Allograft Survival

(2008) A. Melk et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

(2008) Darren J. Baker et al.   NATURE CELL BIOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY