标题
Risk Factors and Emerging Therapies in Amyotrophic Lateral Sclerosis
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 11, Pages 2616
出版商
MDPI AG
发表日期
2019-05-28
DOI
10.3390/ijms20112616
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Early post-marketing experience with edaravone in an unselected group of patients with ALS
- (2019) Alon Abraham et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Edaravone for the treatment of amyotrophic lateral sclerosis
- (2019) Hiide Yoshino Expert Review of Neurotherapeutics
- The molecular pathogenesis of superoxide dismutase 1-linked ALS is promoted by low oxygen tension
- (2019) Isil Keskin et al. ACTA NEUROPATHOLOGICA
- Targeting RNA-Mediated Toxicity in C9orf72 ALS and/or FTD by RNAi-Based Gene Therapy
- (2019) Raygene Martier et al. Molecular Therapy-Nucleic Acids
- Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation
- (2018) Faxiang Li et al. Autophagy
- SOD1 in Amyotrophic Lateral Sclerosis: “Ambivalent” Behavior Connected to the Disease
- (2018) Orietta Pansarasa et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Riluzole, disease stage and survival in ALS
- (2018) Thanuja Dharmadasa et al. LANCET NEUROLOGY
- Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study
- (2018) Ton Fang et al. LANCET NEUROLOGY
- Amyotrophic Lateral Sclerosis: An Update for 2018
- (2018) Björn Oskarsson et al. MAYO CLINIC PROCEEDINGS
- Motor neuron disease in 2017: Progress towards therapy in motor neuron disease
- (2018) Matthew C. Kiernan Nature Reviews Neurology
- Association between TBK1 mutations and risk of amyotrophic lateral sclerosis/frontotemporal dementia spectrum: a meta-analysis
- (2018) Rongrong Cui et al. NEUROLOGICAL SCIENCES
- MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: implications for familial ALS
- (2018) Neta Shvil et al. Cell Death & Disease
- “ALS reversals”: demographics, disease characteristics, treatments, and co-morbidities
- (2018) Daniel Harrison et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs
- (2018) Manoj Kumar Jaiswal MEDICINAL RESEARCH REVIEWS
- The link of organophosphorus pesticides with neurodegenerative and neurodevelopmental diseases based on evidence and mechanisms
- (2018) Sara Mostafalou et al. TOXICOLOGY
- Aggregated SOD1 causes selective death of cultured human motor neurons
- (2018) Chen Benkler et al. Scientific Reports
- Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1G93A ALS rat but has adverse side effects
- (2017) G M Thomsen et al. GENE THERAPY
- A Meta-Analysis on the Relationship of the PON Genes and Alzheimer Disease
- (2017) Yi Nie et al. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
- Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis
- (2017) Zhang-Yu Zou et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis
- (2017) Ming-Dong Wang et al. NEUROTOXICOLOGY
- Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation
- (2017) Tariq Afroz et al. Nature Communications
- ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment?
- (2017) Dmitry Petrov et al. Frontiers in Aging Neuroscience
- Edaravone and its clinical development for amyotrophic lateral sclerosis
- (2017) Koji Takei et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Disease-modifying and symptomatic treatment of amyotrophic lateral sclerosis
- (2017) Johannes Dorst et al. Therapeutic Advances in Neurological Disorders
- Non-neuronal Cells in ALS: Role of Glial, Immune cells and Blood-CNS Barriers
- (2016) Fabiola Puentes et al. BRAIN PATHOLOGY
- Pathogenesis of amyotrophic lateral sclerosis
- (2016) Sarah Morgan et al. BRITISH MEDICAL BULLETIN
- Stem cells therapy for ALS
- (2016) Letizia Mazzini et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Amyotrophic lateral sclerosis and environmental factors
- (2016) Virginia Bozzoni FUNCTIONAL NEUROLOGY
- Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies
- (2016) Roberta Cascella et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- GPNMB ameliorates mutant TDP-43-induced motor neuron cell death
- (2016) Yuki Nagahara et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration
- (2016) Brittany M. Edens et al. Frontiers in Cellular Neuroscience
- Riluzole exerts transient modulating effects on cortical and axonal hyperexcitability in ALS
- (2016) Nimeshan Geevasinga et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease
- (2015) Cyril Pottier et al. ACTA NEUROPATHOLOGICA
- Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis
- (2015) A. E. Elia et al. EUROPEAN JOURNAL OF NEUROLOGY
- Human glial progenitor engraftment and gene expression is independent of the ALS environment
- (2015) Amanda M. Haidet-Phillips et al. EXPERIMENTAL NEUROLOGY
- Erythropoietin in amyotrophic lateral sclerosis: a multicentre, randomised, double blind, placebo controlled, phase III study
- (2015) Giuseppe Lauria et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Oxidative Stress in Neurodegenerative Diseases
- (2015) Ewa Niedzielska et al. MOLECULAR NEUROBIOLOGY
- Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
- (2015) Axel Freischmidt et al. NATURE NEUROSCIENCE
- Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era
- (2015) Ximena Paez-Colasante et al. Nature Reviews Neurology
- Potential Environmental Factors in Amyotrophic Lateral Sclerosis
- (2015) Björn Oskarsson et al. NEUROLOGIC CLINICS
- Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin
- (2015) Alexandre Amlie-Wolf et al. PLoS One
- Delayed Disease Onset and Extended Survival in the SOD1G93A Rat Model of Amyotrophic Lateral Sclerosis after Suppression of Mutant SOD1 in the Motor Cortex
- (2014) G. M. Thomsen et al. JOURNAL OF NEUROSCIENCE
- A Meta-Analysis of Observational Studies of the Association Between Chronic Occupational Exposure to Lead and Amyotrophic Lateral Sclerosis
- (2014) Ming-Dong Wang et al. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
- Advances in motor neurone disease
- (2014) Dirk Bäumer et al. JOURNAL OF THE ROYAL SOCIETY OF MEDICINE
- Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
- (2014) Chiara Cossetti et al. MOLECULAR CELL
- 7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis
- (2014) Orhan Tansel Korkmaz et al. NEUROSCIENCE LETTERS
- Dexpramipexole Is Ineffective in Two Models of ALS Related Neurodegeneration
- (2014) Fernando G. Vieira et al. PLoS One
- A post hoc analysis of subgroup outcomes and creatinine in the phase III clinical trial (EMPOWER) of dexpramipexole in ALS
- (2014) Michael E. Bozik et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Amyotrophic Lateral Sclerosis - Cell Based Therapy and Novel Therapeutic Development
- (2014) Changsung Kim et al. Experimental Neurobiology
- Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS): impact on quality of life and therapeutic options
- (2013) Sonja Körner et al. BMC Neurology
- Is SOD1 loss of function involved in amyotrophic lateral sclerosis?
- (2013) Rachele A. Saccon et al. BRAIN
- Mitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?
- (2013) H Muyderman et al. BRITISH JOURNAL OF PHARMACOLOGY
- Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis
- (2013) Emanuele D’Amico et al. FREE RADICAL BIOLOGY AND MEDICINE
- Exposure to Environmental Toxicants and Pathogenesis of Amyotrophic Lateral Sclerosis: State of the Art and Research Perspectives
- (2013) Francesca Trojsi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial
- (2013) Merit E Cudkowicz et al. LANCET NEUROLOGY
- Polymerase chain reaction and Southern blot-based analysis of the C9orf72 hexanucleotide repeat in different motor neuron diseases
- (2013) Annemarie Hübers et al. NEUROBIOLOGY OF AGING
- Adipose Tissue Distribution Predicts Survival in Amyotrophic Lateral Sclerosis
- (2013) Eva Lindauer et al. PLoS One
- Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1
- (2013) Daqi Tu et al. Cell Reports
- Crystal Structure and Mechanism of Activation of TANK-Binding Kinase 1
- (2013) Amede Larabi et al. Cell Reports
- Body mass index (BMI) as predictor of ALSFRS-R score decline in ALS patients
- (2013) Ronit Reich-Slotky et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Effect of Acute Extremely Low Frequency Electromagnetic Field Exposure on the Antioxidant Status and Lipid Levels in Rat Brain
- (2012) Jesús Martínez-Sámano et al. ARCHIVES OF MEDICAL RESEARCH
- Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72
- (2012) Johnathan Cooper-Knock et al. BRAIN
- Neural stem cells: therapeutic potential for neurodegenerative diseases
- (2012) G. Gincberg et al. BRITISH MEDICAL BULLETIN
- Frontotemporal Lobar Degeneration
- (2012) Rachel E. Seltman et al. CNS DRUGS
- Oropharyngeal dysphagia in amyotrophic lateral sclerosis alters quality of life
- (2012) G. Paris et al. JOURNAL OF ORAL REHABILITATION
- Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study
- (2012) Elisa Majounie et al. LANCET NEUROLOGY
- The C9orf72 hexanucleotide repeat expansion in FTD and ALS
- (2012) Eileen H. Bigio Nature Reviews Neurology
- Regulation of FMO and PON Detoxication Systems in ALS Human Tissues
- (2012) Stella Gagliardi et al. NEUROTOXICITY RESEARCH
- Association between Extremely Low-Frequency Electromagnetic Fields Occupations and Amyotrophic Lateral Sclerosis: A Meta-Analysis
- (2012) Hongjie Zhou et al. PLoS One
- Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases
- (2012) Amber L. Southwell et al. TRENDS IN MOLECULAR MEDICINE
- The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis
- (2012) Hirotaka Tanaka et al. Scientific Reports
- Premorbid body mass index and risk of amyotrophic lateral sclerosis
- (2012) Éilis J. O'Reilly et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β
- (2011) Catherine E. Gleason et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation
- (2011) Yi-Hung Ou et al. MOLECULAR CELL
- Body mass index, not dyslipidemia, is an independent predictor of survival in amyotrophic lateral sclerosis
- (2011) Sabrina Paganoni et al. MUSCLE & NERVE
- Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
- (2011) Han-Xiang Deng et al. NATURE
- Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
- (2011) Laura Ferraiuolo et al. Nature Reviews Neurology
- Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
- (2011) Mariely DeJesus-Hernandez et al. NEURON
- A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
- (2011) Alan E. Renton et al. NEURON
- Human Glial-Restricted Progenitor Transplantation into Cervical Spinal Cord of the SOD1G93A Mouse Model of ALS
- (2011) Angelo C. Lepore et al. PLoS One
- Stem cell technology for the study and treatment of motor neuron diseases
- (2011) J Simon Lunn et al. Regenerative Medicine
- TBK1 Mediates Crosstalk Between the Innate Immune Response and Autophagy
- (2011) H. Weidberg et al. Science Signaling
- Current Challenges for the Advancement of Neural Stem Cell Biology and Transplantation Research
- (2011) Kristien Reekmans et al. Stem Cell Reviews and Reports
- Association Between Blood Lead and the Risk of Amyotrophic Lateral Sclerosis
- (2010) F. Fang et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Paraoxonase gene mutations in amyotrophic lateral sclerosis
- (2010) Nicola Ticozzi et al. ANNALS OF NEUROLOGY
- Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis
- (2010) S. Byrne et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study
- (2010) Hannu Laaksovirta et al. LANCET NEUROLOGY
- Capturing VCP: Another Molecular Piece in the ALS Jigsaw Puzzle
- (2010) Christopher E. Shaw NEURON
- Caloric Restriction Shortens Lifespan through an Increase in Lipid Peroxidation, Inflammation and Apoptosis in the G93A Mouse, an Animal Model of ALS
- (2010) Barkha P. Patel et al. PLoS One
- Current and emerging treatments for amyotrophic lateral sclerosis
- (2010) Zoccolella Neuropsychiatric Disease and Treatment
- Exposure to chemicals and metals and risk of amyotrophic lateral sclerosis: A systematic review
- (2009) Nadia A. Sutedja et al. Amyotrophic Lateral Sclerosis
- Microglia in ALS: The Good, The Bad, and The Resting
- (2009) Jenny S. Henkel et al. Journal of Neuroimmune Pharmacology
- Incidence of amyotrophic lateral sclerosis in Europe
- (2009) G. Logroscino et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Intravenous Administration of Self-complementary AAV9 Enables Transgene Delivery to Adult Motor Neurons
- (2009) Sandra Duque et al. MOLECULAR THERAPY
- The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria
- (2009) Teresa L M Thurston et al. NATURE IMMUNOLOGY
- Amyotrophic lateral sclerosis
- (2009) Lokesh C Wijesekera et al. Orphanet Journal of Rare Diseases
- Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
- (2009) T. J. Kwiatkowski et al. SCIENCE
- SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model
- (2008) Maged M. Harraz et al. JOURNAL OF CLINICAL INVESTIGATION
- Focal transplantation–based astrocyte replacement is neuroprotective in a model of motor neuron disease
- (2008) Angelo C Lepore et al. NATURE NEUROSCIENCE
- Genetics of Amyotrophic Lateral Sclerosis
- (2008) Nailah Siddique et al. Physical Medicine and Rehabilitation Clinics of North America
- T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
- (2008) I. M. Chiu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Novel Mutations in TARDBP (TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis
- (2008) Nicola J. Rutherford et al. PLoS Genetics
- Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease
- (2007) Emanuele Buratti Frontiers in Bioscience-Landmark
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started