C-Type Natriuretic Peptide: A Multifaceted Paracrine Regulator in the Heart and Vasculature

Endothelial C-Type Natriuretic Peptide is a Critical Regulator of Angiogenesis and Vascular Remodeling

(2019) Kristen J. Bubb et al.   CIRCULATION

NPR-C (Natriuretic Peptide Receptor-C) Modulates the Progression of Angiotensin II–Mediated Atrial Fibrillation and Atrial Remodeling in Mice

(2019) Hailey J. Jansen et al.   Circulation-Arrhythmia and Electrophysiology

C-type natriuretic peptide co-ordinates cardiac structure and function

(2019) Amie J Moyes et al.   EUROPEAN HEART JOURNAL

CRRL269

(2019) Yang Chen et al.   CIRCULATION RESEARCH

C53: A novel particulate guanylyl cyclase B receptor activator that has sustained activity in vivo with anti-fibrotic actions in human cardiac and renal fibroblasts

(2019) Yang Chen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Endothelial C-Type Natriuretic Peptide Acts on Pericytes to Regulate Microcirculatory Flow and Blood Pressure

(2018) Katarina Špiranec et al.   CIRCULATION

A New Secretory Peptide of Natriuretic Peptide Family, Osteocrin, Suppresses the Progression of Congestive Heart Failure After Myocardial InfarctionNovelty and Significance

(2018) Takahiro Miyazaki et al.   CIRCULATION RESEARCH

Natriuretic peptide based therapeutics for heart failure: Cenderitide: A novel first-in-class designer natriuretic peptide

(2018) Tomoko Ichiki et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Abdominal aortic aneurysm: Sex differences

(2018) Christina Villard et al.   MATURITAS

Absence of NPR-C Attenuates TGF-ß1 Induced Selective Atrial Fibrosis and Atrial Fibrillation

(2018) Dolkun Rahmutula et al.   CARDIOVASCULAR RESEARCH

C-type natriuretic peptide (CNP) in endothelial cells attenuates hepatic fibrosis and inflammation in non-alcoholic steatohepatitis

(2018) Cho-Rong Bae et al.   LIFE SCIENCES

Diagnostic value of NT-proCNP compared to NSE and S100B in cerebrospinal fluid and plasma of patients with sepsis-associated encephalopathy

(2018) Johannes Ehler et al.   NEUROSCIENCE LETTERS

PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts

(2017) Silja Meier et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle

(2017) Meixia Ren et al.   HUMAN MOLECULAR GENETICS

Endothelium-Derived C-Type Natriuretic Peptide Contributes to Blood Pressure Regulation by Maintaining Endothelial IntegrityNovelty and Significance

(2017) Kazuhiro Nakao et al.   HYPERTENSION

Effects of gene knockdown of CNP on ventricular remodeling after myocardial ischemia-reperfusion injury through NPRB/Cgmp signaling pathway in rats

(2017) Lian-He Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Angiotensin Receptor Neprilysin Inhibition in Heart Failure With Preserved Ejection Fraction

(2017) Scott D. Solomon et al.   JACC-Heart Failure

Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice

(2017) Mark C. Blaser et al.   CIRCULATION RESEARCH

Overexpression of C-type Natriuretic Peptide in Endothelial Cells Protects against Insulin Resistance and Inflammation during Diet-induced Obesity

(2017) Cho-Rong Bae et al.   Scientific Reports

Altered heart rate regulation by the autonomic nervous system in mice lacking natriuretic peptide receptor C (NPR-C)

(2017) Motahareh Moghtadaei et al.   Scientific Reports

C-type natriuretic peptide prevents kidney injury and attenuates oxidative and inflammatory responses in hemorrhagic shock

(2016) Gan Chen et al.   AMINO ACIDS

C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function

(2016) Jens Buttgereit et al.   CARDIOVASCULAR RESEARCH

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

C-Type Natriuretic Peptides in Coronary Disease

(2016) Timothy C.R. Prickett et al.   CLINICAL CHEMISTRY

Characterization of Relaxant Responses to Natriuretic Peptides in the Human MicrocirculationIn VitroandIn Vivo

(2016) Marie-Louise Edvinsson et al.   MICROCIRCULATION

Vascular Tone Regulation Induced by C-Type Natriuretic Peptide: Differences in Endothelium-Dependent and -Independent Mechanisms Involved in Normotensive and Spontaneously Hypertensive Rats

(2016) Carolina Caniffi et al.   PLoS One

The Endothelium in Sepsis

(2016) Can Ince et al.   SHOCK

Is enhancing cGMP-PKG signalling a promising therapeutic target for heart failure with preserved ejection fraction?

(2016) Á. Kovács et al.   Netherlands Heart Journal

Circulating C-Type Natriuretic Peptide and Its Relationship to Cardiovascular Disease in the General PopulationNovelty and Significance

(2015) S. Jeson Sangaralingham et al.   HYPERTENSION

Impaired sinoatrial node function and increased susceptibility to atrial fibrillation in mice lacking natriuretic peptide receptor C

(2015) Emmanuel E. Egom et al.   JOURNAL OF PHYSIOLOGY-LONDON

C-type natriuretic peptide attenuates lipopolysaccharide-induced acute lung injury in mice

(2015) Toru Kimura et al.   JOURNAL OF SURGICAL RESEARCH

C-type natriuretic peptide attenuates LPS-induced endothelial activation: involvement of p38, Akt, and NF-κB pathways

(2014) Gan Chen et al.   AMINO ACIDS

Natriuretic peptides modulate ATP-sensitive K+ channels in rat ventricular cardiomyocytes

(2014) Dwaine S. Burley et al.   BASIC RESEARCH IN CARDIOLOGY

Natriuretic peptide clearance receptor ligand (C-ANP4-23) attenuates angiogenesis in a murine sponge implant model

(2014) S.A. Almeida et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Prognostic value of N-terminal pro C-type natriuretic peptide in heart failure patients with preserved and reduced ejection fraction

(2014) Dirk J. Lok et al.   EUROPEAN JOURNAL OF HEART FAILURE

Natriuretic Peptide Receptor-C Attenuates Hypertension in Spontaneously Hypertensive Rats

(2014) Yuan Li et al.   HYPERTENSION

Efficacy and Safety of LCZ696, a First-in-Class Angiotensin Receptor Neprilysin Inhibitor, in Asian Patients With Hypertension

(2014) Kazuomi Kario et al.   HYPERTENSION

Differential gene expression of C-type natriuretic peptide and its related molecules in dilated and ischemic cardiomyopathy. A new option for the management of heart failure

(2014) Estefanía Tarazón et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Endothelial C-type natriuretic peptide maintains vascular homeostasis

(2014) Amie J. Moyes et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac fibrosis in end-stage human heart failure and the cardiac natriuretic peptide guanylyl cyclase system: Regulation and therapeutic implications

(2014) Tomoko Ichiki et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inhibitory effects of C-type natriuretic peptide on the differentiation of cardiac fibroblasts, and secretion of monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1

(2014) ZHI-QIANG LI et al.   Molecular Medicine Reports

Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure

(2014) John J.V. McMurray et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Functional Genetic Variant (N521D) in Natriuretic Peptide Receptor 3 Is Associated with Diastolic Dysfunction: The Prevalence of Asymptomatic Ventricular Dysfunction Study

(2014) Naveen L. Pereira et al.   PLoS One

SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium

(2013) L R Moltzau et al.   BRITISH JOURNAL OF PHARMACOLOGY

High concentration of C-type natriuretic peptide promotes VEGF-dependent vasculogenesis in the remodeled region of infarcted swine heart with preserved left ventricular ejection fraction

(2013) S. Del Ry et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

(2013) Derek J. Hausenloy et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Musclin in the Pathogenesis of Hypertension in Rat

(2013) Ying-Xiao Li et al.   PLoS One

Natriuretic peptides regulate heart rate and sinoatrial node function by activating multiple natriuretic peptide receptors

(2012) John Azer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors

(2012) Jeremy Springer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Overexpressed C-type natriuretic peptide serves as an early compensatory response to counteract extracellular matrix remodeling in unilateral ureteral obstruction rats

(2012) Peng Hu et al.   MOLECULAR BIOLOGY REPORTS

C-type natriuretic peptide: A new cardiac mediator

(2012) S. Del Ry   PEPTIDES

CD-NP: A Novel Engineered Dual Guanylyl Cyclase Activator with Anti-Fibrotic Actions in the Heart

(2012) Fernando L. Martin et al.   PLoS One

Interleukin-1β, tumour necrosis factor-α and lipopolysaccharide induce C-type natriuretic peptide from canine aortic endothelial cells

(2012) Kara Osterbur et al.   RESEARCH IN VETERINARY SCIENCE

Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide

(2011) Rayomand S Khambata et al.   BRITISH JOURNAL OF PHARMACOLOGY

Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I

(2011) Stefan Frantz et al.   EUROPEAN HEART JOURNAL

Dendroaspis natriuretic peptide and the designer natriuretic peptide, CD-NP, are resistant to proteolytic inactivation

(2011) Deborah M. Dickey et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Guanylyl cyclase (GC)-A and GC-B activities in ventricles and cardiomyocytes from failed and non-failed human hearts: GC-A is inactive in the failed cardiomyocyte

(2011) Deborah M. Dickey et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

(2011) Georg B. Ehret et al.   NATURE

Expression of C-type natriuretic peptide and its receptor NPR-B in cardiomyocytes

(2011) S. Del Ry et al.   PEPTIDES

Transforming growth factor-β1 regulation of C-type natriuretic peptide expression in human vascular smooth muscle cells: dependence on TSC22D1

(2010) Maria C. Mendonça et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of cGMP-PKG signaling in the protection of neonatal rat cardiac myocytes subjected to simulated ischemia/reoxygenation

(2010) Aniko Gorbe et al.   BASIC RESEARCH IN CARDIOLOGY

Associations between genetic variations in the FURIN gene and hypertension

(2010) Nanfang Li et al.   BMC Medical Genetics

The Aging Heart, Myocardial Fibrosis, and its Relationship to Circulating C-Type Natriuretic Peptide

(2010) S. Jeson Sangaralingham et al.   HYPERTENSION

Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study

(2010) Luis Miguel Ruilope et al.   LANCET

C-type natriuretic peptide effects on cardiovascular nitric oxide system in spontaneously hypertensive rats

(2010) Carolina Caniffi et al.   PEPTIDES

Natriuretic peptides increase β1-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition

(2009) Eirik Qvigstad et al.   CARDIOVASCULAR RESEARCH

Circulating NT-proCNP predicts sepsis in multiple-traumatized patients without traumatic brain injury*

(2009) Soheyl Bahrami et al.   CRITICAL CARE MEDICINE

Regional Release and Clearance of C-Type Natriuretic Peptides in the Human Circulation and Relation to Cardiac Function

(2009) Suetonia C. Palmer et al.   HYPERTENSION

Pharmacodynamics Pharmacodynamics of a Novel Designer Natriuretic Peptide, CD-NP, in a First-in-Human Clinical Trial in Healthy Subjects

(2009) Candace Y. W. Lee et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Mechanism of C-type natriuretic peptide-induced endothelial cell hyperpolarization

(2008) Aaron Simon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Effects of Natriuretic Peptides on Intracavernous Pressure and Blood Pressure in Conscious Rats

(2008) Naoki Aizawa et al.   Journal of Sexual Medicine

Expression of C-type natriuretic peptide and of its receptor NPR-B in normal and failing heart

(2008) Silvia Del Ry et al.   PEPTIDES

C-type natriuretic peptide and endothelium-dependent hyperpolarization in the guinea-pig carotid artery

(2007) V Leuranguer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Natriuretic peptide C receptor signalling in the heart and vasculature

(2007) Robert A. Rose et al.   JOURNAL OF PHYSIOLOGY-LONDON