Novel Therapeutic Potentials of Taxifolin for Amyloid-β-associated Neurodegenerative Diseases and Other Diseases: Recent Advances and Future Perspectives

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

(2019) Francesco Panza et al.   Nature Reviews Neurology

Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy

(2019) Takayuki Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The meninges as barriers and facilitators for the movement of fluid, cells and pathogens related to the rodent and human CNS

(2018) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study

(2018) Mark A Rodrigues et al.   LANCET NEUROLOGY

Taxifolin prevents β-amyloid-induced impairments of synaptic formation and deficits of memory via the inhibition of cytosolic phospholipase A2/prostaglandin E2 content

(2018) Yuanyuan Wang et al.   METABOLIC BRAIN DISEASE

Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome

(2018) Tao Ding et al.   PHYTOMEDICINE

Distribution of Lacunar Infarcts in Asians With Intracerebral Hemorrhage

(2018) Hsin-Hsi Tsai et al.   STROKE

Albuminuria Increases the Risks for Both Alzheimer Disease and Vascular Dementia in Community‐Dwelling Japanese Elderly: The Hisayama Study

(2018) Keita Takae et al.   Journal of the American Heart Association

Taxifolin prevents postprandial hyperglycemia by regulating the activity of α-amylase: Evidence from an in vivo and in silico studies

(2018) Kanwal Rehman et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Isolated compounds from Cuscuta pedicellata ameliorate oxidative stress and upregulate expression of some energy regulatory genes in high fat diet induced obesity in rats

(2018) Eman T. Mehanna et al.   BIOMEDICINE & PHARMACOTHERAPY

Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1

(2018) Bruno Alexandre Quadros Gomes et al.   Oxidative Medicine and Cellular Longevity

Long-Term Survival and Function After Stroke

(2018) Stefan Sennfält et al.   STROKE

Diabetes: The diabetic brain

(2017) John E. Morley   Nature Reviews Endocrinology

Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy

(2017) Satoshi Saito et al.   Acta Neuropathologica Communications

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

(2016) Alan W. J. Morris et al.   ACTA NEUROPATHOLOGICA

Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease

(2016) Raj N. Kalaria   ACTA NEUROPATHOLOGICA

Association Between Diabetes and Hippocampal Atrophy in Elderly Japanese: The Hisayama Study

(2016) Naoki Hirabayashi et al.   DIABETES CARE

Acceleration of Amyloidosis by Inflammation in the Amyloid-Beta Marmoset Monkey Model of Alzheimer’s Disease

(2016) Ingrid H. Philippens et al.   JOURNAL OF ALZHEIMERS DISEASE

Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial

(2016) Eric P Moll van Charante et al.   LANCET

Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

(2016)   LANCET

Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MSn

(2016) Ping Yang et al.   MOLECULES

β-Amyloid in CSF

(2016) Ellis S. van Etten et al.   NEUROLOGY

Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of β-Amyloid Accumulation and Neurotoxicity via the Suppression of P-JAK2/P-STAT3/NF-κB/BACE1 Signaling Pathways

(2016) So Youn Park et al.   PLoS One

Does the difference between PART and Alzheimer’s disease lie in the age-related changes in cerebral arteries that trigger the accumulation of Aβ and propagation of tau?

(2015) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Cerebral Microbleeds, CSF p-Tau, and Cognitive Decline: Significance of Anatomic Distribution

(2015) G.C. Chiang et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions

(2015) Andreas Charidimou et al.   BRAIN

Mild Cognitive Impairment: At the Crossroad of Neurodegeneration and Vascular Dysfunction

(2015) Satoshi Saito et al.   Current Alzheimer Research

Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia

(2015) Saion Chatterjee et al.   DIABETES CARE

Toxicological and Genotoxicity Assessment of a Dihydroquercetin-Rich Dahurian Larch Tree (Larix gmelinii Rupr) Extract (Lavitol)

(2015) Alexander G. Schauss et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

The role of cytosolic phospholipase A2α in amyloid precursor protein induction by amyloid beta1-42: implication for neurodegeneration

(2015) Chen Sagy-Bross et al.   JOURNAL OF NEUROCHEMISTRY

Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons

(2015) Patricia A. Boyle et al.   NEUROLOGY

Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice

(2015) Byung Hee Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BMI and risk of dementia in two million people over two decades: a retrospective cohort study

(2015) Nawab Qizilbash et al.   Lancet Diabetes & Endocrinology

Cerebral Amyloid Angiopathy: Emerging Concepts

(2015) Masahito Yamada   Journal of Stroke

Outcome markers for clinical trials in cerebral amyloid angiopathy

(2014) Steven M Greenberg et al.   LANCET NEUROLOGY

Effect of metabolites isolated from Cuscuta pedicellata on high fat diet-fed rats

(2014) Salwa H. Zekry et al.   MEDICINAL CHEMISTRY RESEARCH

Age-Dependent Neurovascular Dysfunction and Damage in a Mouse Model of Cerebral Amyloid Angiopathy

(2014) Laibaik Park et al.   STROKE

New Therapeutic Approaches for Alzheimer’s Disease and Cerebral Amyloid Angiopathy

(2014) Satoshi Saito et al.   Frontiers in Aging Neuroscience

The Cerebrovascular Basement Membrane: Role in the Clearance of β-amyloid and Cerebral Amyloid Angiopathy

(2014) Alan W. J. Morris et al.   Frontiers in Aging Neuroscience

Epidemic Spreading Model to Characterize Misfolded Proteins Propagation in Aging and Associated Neurodegenerative Disorders

(2014) Yasser Iturria-Medina et al.   PLoS Computational Biology

Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid

(2014) Takakuni Maki et al.   Annals of Clinical and Translational Neurology

Phospholipase A2 – nexus of aging, oxidative stress, neuronal excitability, and functional decline of the aging nervous system? Insights from a snail model system of neuronal aging and age-associated memory impairment

(2014) Petra M. Hermann et al.   Frontiers in Genetics

Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models

(2013) Michal Arbel-Ornath et al.   ACTA NEUROPATHOLOGICA

Janus Kinase 3 Activity Is Necessary for Phosphorylation of Cytosolic Phospholipase A2 and Prostaglandin E2 Synthesis by Macrophages Infected with Francisella tularensis Live Vaccine Strain

(2013) Ashley M. Brummett et al.   INFECTION AND IMMUNITY

Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues

(2013) Mizuho Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebral oxidative stress induces spatial working memory dysfunction in uremic mice: neuroprotective effect of tempol

(2013) K. Fujisaki et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Estimating cerebral microinfarct burden from autopsy samples

(2013) M. B. Westover et al.   NEUROLOGY

Increased Number of Microinfarcts in Alzheimer Disease at 7-T MR Imaging

(2013) Sanneke van Rooden et al.   RADIOLOGY

Brain and Circulating Levels of Aβ1–40 Differentially Contribute to Vasomotor Dysfunction in the Mouse Brain

(2012) Laibaik Park et al.   STROKE

Critical evaluation of the role of acarbose in the treatment of diabetes: patient considerations

(2012) Christoph Rosak et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

(2011) Cheryl A. Hawkes et al.   ACTA NEUROPATHOLOGICA

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

(2011) Chia-Hsiung Chen et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Low-n oligomers as therapeutic targets of Alzheimer’s disease

(2011) Kenjiro Ono et al.   JOURNAL OF NEUROCHEMISTRY

Chronic kidney disease, cognitive decline, and incident dementia: The 3C Study

(2011) C. Helmer et al.   NEUROLOGY

Glucose tolerance status and risk of dementia in the community: The Hisayama Study

(2011) T. Ohara et al.   NEUROLOGY

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Cerebrospinal fluid amyloid β40is decreased in cerebral amyloid angiopathy

(2009) Marcel M. Verbeek et al.   ANNALS OF NEUROLOGY

β-Amyloid, Blood Vessels, and Brain Function

(2009) Eric E. Smith et al.   STROKE

NFκB-dependent Control ofBACE1Promoter Transactivation by Aβ42

(2008) Virginie Buggia-Prevot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2in cortical neurons

(2008) Phullara B. Shelat et al.   JOURNAL OF NEUROCHEMISTRY

Cerebrovascular Dysfunction in Amyloid Precursor Protein Transgenic Mice: Contribution of Soluble and Insoluble Amyloid-  Peptide, Partial Restoration via  -Secretase Inhibition

(2008) B. H. Han et al.   JOURNAL OF NEUROSCIENCE