Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues

Structure–Activity Relationship for (+)-Taxifolin Isolated from Silymarin as an Inhibitor of Amyloid β Aggregation

(2013) Mizuho SATO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

Toward the Molecular Mechanism(s) by Which EGCG Treatment Remodels Mature Amyloid Fibrils

(2013) Fernando L. Palhano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Key Role for Lysine Residues in Amyloid β-Protein Folding, Assembly, and Toxicity

(2012) Sharmistha Sinha et al.   ACS Chemical Neuroscience

Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers

(2012) A. Attar et al.   BRAIN

Phenolic Compounds Prevent Amyloid β-Protein Oligomerization and Synaptic Dysfunction by Site-specific Binding

(2012) Kenjiro Ono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Properties of EGCG-Induced, Nontoxic Alzheimer's Disease Aβ Oligomers

(2012) Juan Miguel Lopez del Amo et al.   JOURNAL OF MOLECULAR BIOLOGY

3,3′,4′,5,5′-Pentahydroxyflavone is a potent inhibitor of amyloid β fibril formation

(2012) Hiroko Ushikubo et al.   NEUROSCIENCE LETTERS

Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation

(2012) L Kulic et al.   Translational Psychiatry

Hydrophobicity and Conformational Change as Mechanistic Determinants for Nonspecific Modulators of Amyloid β Self-Assembly

(2011) Axel Abelein et al.   BIOCHEMISTRY

Dihydroxybenzoic Acid Isomers Differentially Dissociate Soluble Biotinyl-Aβ(1–42) Oligomers

(2011) Harry LeVine et al.   BIOCHEMISTRY

Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

(2011) Patrizia Mecocci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid β-protein fibrils

(2011) Yuichi Masuda et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease

(2011) Robert J. Williams et al.   FREE RADICAL BIOLOGY AND MEDICINE

SOD1 (Copper/Zinc Superoxide Dismutase) Deficiency Drives Amyloid β Protein Oligomerization and Memory Loss in Mouse Model of Alzheimer Disease

(2011) Kazuma Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

(2011) Sharmistha Sinha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Drugs: A tangled web of targets

(2011) Lauren Gravitz   NATURE

Monoclonal Antibody Against the Turn of the 42-Residue Amyloid β-Protein at Positions 22 and 23

(2010) Kazuma Murakami et al.   ACS Chemical Neuroscience

Relationship between the tautomeric structures of curcumin derivatives and their Aβ-binding activities in the context of therapies for Alzheimer's disease

(2010) Daijiro Yanagisawa et al.   BIOMATERIALS

Silymarin Attenuated the Amyloid β Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer’s Disease Mouse Model

(2010) Nakaba MURATA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Current therapeutic targets for the treatment of Alzheimer’s disease

(2010) Joshua D Grill et al.   Expert Review of Neurotherapeutics

Structurally distinct toxicity inhibitors bind at common loci on β-amyloid fibril

(2010) Ben Keshet et al.   PROTEIN SCIENCE

Stereospecific high-performance liquid chromatography of taxifolin, applications in pharmacokinetics, and determination in tu fu ling (Rhizoma smilacis glabrae) and apple (Malus×domestica)

(2009) Karina R. Vega-Villa et al.   BIOMEDICAL CHROMATOGRAPHY

Identification of Physiological and Toxic Conformations in Aβ42 Aggregates

(2009) Yuichi Masuda et al.   CHEMBIOCHEM

Catechol derivatives inhibit the fibril formation of amyloid-β peptides

(2009) Vu Thi Huong et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Elderberry flavonoids bind to and prevent H1N1 infection in vitro

(2009) Bill Roschek et al.   PHYTOCHEMISTRY

Cytotoxic constituents from the bark of Salix hulteni

(2008) Seong Ho Jeon et al.   ARCHIVES OF PHARMACAL RESEARCH

Covalent modification of proteins by green tea polyphenol (–)-epigallocatechin-3-gallate through autoxidation

(2008) Takeshi Ishii et al.   FREE RADICAL BIOLOGY AND MEDICINE

Amyloid β-Protein Assembly and Alzheimer Disease

(2008) Robin Roychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Benefits from Dietary Polyphenols for Brain Aging and Alzheimer’s Disease

(2008) L. Rossi et al.   NEUROCHEMICAL RESEARCH

Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid β protein

(2008) Tatsuhiro Akaishi et al.   NEUROSCIENCE LETTERS

Oxidative Stress and Neurotoxicity

(2007) Lawrence M. Sayre et al.   CHEMICAL RESEARCH IN TOXICOLOGY