Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues

Lysosomal storage disorders – challenges, concepts and avenues for therapy: beyond rare diseases

(2019) André R. A. Marques et al.   JOURNAL OF CELL SCIENCE

The Opposing Contribution of SMS1 and SMS2 to Glioma Progression and Their Value in the Therapeutic Response to 2OHOA

(2019) Paula Fernández-García et al.   Cancers

Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes

(2019) Shreya Endapally et al.   CELL

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases

(2018) Varman T. Samuel et al.   Cell Metabolism

Membranes and evolution

(2018) Sven B. Gould   CURRENT BIOLOGY

Transbilayer lipid asymmetry

(2018) Toshihide Kobayashi et al.   CURRENT BIOLOGY

Phospholipid transport protein function at organelle contact sites

(2018) Shamshad Cockcroft et al.   CURRENT OPINION IN CELL BIOLOGY

Cellular mechanisms of physicochemical membrane homeostasis

(2018) Robert Ernst et al.   CURRENT OPINION IN CELL BIOLOGY

Cellular and Molecular Mechanisms of Anti-Phospholipid Syndrome

(2018) Marko Radic et al.   Frontiers in Immunology

Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase

(2018) Byoung-Cheol Lee et al.   Nature Communications

Nuclear phosphoinositide regulation of chromatin

(2017) Bree L. Hamann et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pulmonary surfactant dysfunction in pediatric cystic fibrosis: Mechanisms and reversal with a lipid-sequestering drug

(2017) Lasantha Gunasekara et al.   Journal of Cystic Fibrosis

Activation of the Unfolded Protein Response by Lipid Bilayer Stress

(2017) Kristina Halbleib et al.   MOLECULAR CELL

Lysosomes as Oxidative Targets for Cancer Therapy

(2017) Rebecca F. Dielschneider et al.   Oxidative Medicine and Cellular Longevity

Emerging Roles for the Lysosome in Lipid Metabolism

(2017) Ashley M. Thelen et al.   TRENDS IN CELL BIOLOGY

Lipid-mediated PX-BAR domain recruitment couples local membrane constriction to endocytic vesicle fission

(2017) Johannes Schöneberg et al.   Nature Communications

Structural determinants and functional consequences of protein affinity for membrane rafts

(2017) Joseph H. Lorent et al.   Nature Communications

Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

(2017) Rodney Elwood Infante et al.   eLife

ω-3 polyunsaturated fatty acids direct differentiation of the membrane phenotype in mesenchymal stem cells to potentiate osteogenesis

(2017) Kandice R. Levental et al.   Science Advances

Active membrane cholesterol as a physiological effector

(2016) Yvonne Lange et al.   CHEMISTRY AND PHYSICS OF LIPIDS

TFEB at a glance

(2016) Gennaro Napolitano et al.   JOURNAL OF CELL SCIENCE

Lipids, lysosomes, and autophagy

(2016) Bharat Jaishy et al.   JOURNAL OF LIPID RESEARCH

Remodeling of the postsynaptic plasma membrane during neural development

(2016) Karolina Tulodziecka et al.   MOLECULAR BIOLOGY OF THE CELL

A Eukaryotic Sensor for Membrane Lipid Saturation

(2016) Roberto Covino et al.   MOLECULAR CELL

Nuclear Lipids in the Nervous System: What they do in Health and Disease

(2016) Mercedes Garcia-Gil et al.   NEUROCHEMICAL RESEARCH

Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane

(2016) Edouard M. Bevers et al.   PHYSIOLOGICAL REVIEWS

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

The New Antitumor Drug ABTL0812 Inhibits the Akt/mTORC1 Axis by Upregulating Tribbles-3 Pseudokinase

(2015) T. Erazo et al.   CLINICAL CANCER RESEARCH

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

(2015) Catherine L. Nezich et al.   JOURNAL OF CELL BIOLOGY

Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment

(2015) Pablo V. Escribá et al.   PROGRESS IN LIPID RESEARCH

Protein Prenylation: Enzymes, Therapeutics, and Biotechnology Applications

(2014) Charuta C. Palsuledesai et al.   ACS Chemical Biology

Rafting through traffic: Membrane domains in cellular logistics

(2014) Blanca Diaz-Rohrer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Regulation of the cancer cell membrane lipid composition by NaCHOleate

(2014) Victoria Lladó et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The effect of natural and synthetic fatty acids on membrane structure, microdomain organization, cellular functions and human health

(2014) Maitane Ibarguren et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease

(2014) Manuel Torres et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipid landscapes and pipelines in membrane homeostasis

(2014) Joost C.M. Holthuis et al.   NATURE

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Membrane raft association is a determinant of plasma membrane localization

(2014) B. B. Diaz-Rohrer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid compartmentalization in the endosome system

(2014) Françoise Hullin-Matsuda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The role of membrane fatty acid remodeling in the antitumor mechanism of action of 2-hydroxyoleic acid

(2013) Maria Laura Martin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Partitioning of liquid-ordered/liquid-disordered membrane microdomains induced by the fluidifying effect of 2-hydroxylated fatty acid derivatives

(2013) Maitane Ibarguren et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipid Replacement Therapy: A natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function

(2013) Garth L. Nicolson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer’s disease following 2-hydroxy-DHA treatment

(2013) Maria A. Fiol-deRoque et al.   BIOGERONTOLOGY

Amphipathic Lipid Packing Sensor Motifs: Probing Bilayer Defects with Hydrophobic Residues

(2013) Stefano Vanni et al.   BIOPHYSICAL JOURNAL

Both TMEM16F-dependent and TMEM16F-independent pathways contribute to phosphatidylserine exposure in platelet apoptosis and platelet activation

(2013) R. van Kruchten et al.   BLOOD

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

(2013) F. Baenke et al.   Disease Models & Mechanisms

Short transmembrane domains with high-volume exoplasmic halves determine retention of Type II membrane proteins in the Golgi complex

(2013) R. Quiroga et al.   JOURNAL OF CELL SCIENCE

Interaction of Miltefosine with the Lipid and Protein Components of the Erythrocyte Membrane

(2013) Rodrigo Alves Moreira et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Lipid E-MAP Identifies Ubx2 as a Critical Regulator of Lipid Saturation and Lipid Bilayer Stress

(2013) Michal A. Surma et al.   MOLECULAR CELL

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion

(2013) Amelia E. Hochreiter-Hufford et al.   NATURE

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipid raft disarrangement as a result of neuropathological progresses: A novel strategy for early diagnosis?

(2013) R. Marin et al.   NEUROSCIENCE

Role of Phospholipids in Endocytosis, Phagocytosis, and Macropinocytosis

(2013) Michal Bohdanowicz et al.   PHYSIOLOGICAL REVIEWS

Checks and balances in membrane phospholipid class and acyl chain homeostasis, the yeast perspective

(2013) Anton I.P.M. de Kroon et al.   PROGRESS IN LIPID RESEARCH

Lipids of mitochondria

(2013) Susanne E. Horvath et al.   PROGRESS IN LIPID RESEARCH

Biological functions of sphingomyelins

(2013) J. Peter Slotte   PROGRESS IN LIPID RESEARCH

Mitochondrial lipid trafficking

(2013) Takashi Tatsuta et al.   TRENDS IN CELL BIOLOGY

Phospholipid flippases: Building asymmetric membranes and transport vesicles

(2012) Tessy T. Sebastian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)

(2012) Arun Raturi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Connecting the nucleus to the cytoskeleton by SUN–KASH bridges across the nuclear envelope

(2012) Erin C Tapley et al.   CURRENT OPINION IN CELL BIOLOGY

Curvature, Lipid Packing, and Electrostatics of Membrane Organelles: Defining Cellular Territories in Determining Specificity

(2012) Joëlle Bigay et al.   DEVELOPMENTAL CELL

G Protein-coupled Estrogen Receptor Mediates the Up-regulation of Fatty Acid Synthase Induced by 17β-Estradiol in Cancer Cells and Cancer-associated Fibroblasts

(2012) Maria Francesca Santolla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers

(2012) E. Evangelisti et al.   JOURNAL OF CELL SCIENCE

Genetic polymorphisms in fatty acid metabolism genes and colorectal cancer

(2012) M. Crous-Bou et al.   MUTAGENESIS

Endoplasmic reticulum–mitochondria contacts: function of the junction

(2012) Ashley A. Rowland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Flexibility of a Eukaryotic Lipidome – Insights from Yeast Lipidomics

(2012) Christian Klose et al.   PLoS One

2-Hydroxyoleic Acid Induces ER Stress and Autophagy in Various Human Glioma Cell Lines

(2012) Amaia Marcilla-Etxenike et al.   PLoS One

2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy

(2012) S. Teres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prenyltransferase inhibitors: treating human ailments from cancer to parasitic infections

(2012) Joshua D. Ochocki et al.   MedChemComm

Long-Chain Omega-3 Fatty Acids and Blood Pressure

(2011) J. C. Liu et al.   AMERICAN JOURNAL OF HYPERTENSION

Sphingolipids in cancer

(2011) Hideki Furuya et al.   CANCER AND METASTASIS REVIEWS

Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression

(2011) M. Hilvo et al.   CANCER RESEARCH

Linking Lipid Metabolism to the Innate Immune Response in Macrophages through Sterol Regulatory Element Binding Protein-1a

(2011) Seung-Soon Im et al.   Cell Metabolism

Plasmalogens the neglected regulatory and scavenging lipid species

(2011) Stefan Wallner et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Endocytosis and signaling

(2011) Harald W Platta et al.   CURRENT OPINION IN CELL BIOLOGY

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

(2011) Diego L. Medina et al.   DEVELOPMENTAL CELL

High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine

(2011) Gregory D. Fairn et al.   JOURNAL OF CELL BIOLOGY

Making heads or tails of phospholipids in mitochondria

(2011) Christof Osman et al.   JOURNAL OF CELL BIOLOGY

M2 Macrophages Induced by Prostaglandin E2 and IL-6 from Cervical Carcinoma Are Switched to Activated M1 Macrophages by CD4+ Th1 Cells

(2011) M. Heusinkveld et al.   JOURNAL OF IMMUNOLOGY

Neuroprotective and Ameliorative Actions of Polyunsaturated Fatty Acids Against Neuronal Diseases: Beneficial Effect of Docosahexaenoic Acid on Cognitive Decline in Alzheimer’s Disease

(2011) Michio Hashimoto et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

Treatment of Rat Spinal Cord Injury with the Neurotrophic Factor Albumin-Oleic Acid: Translational Application for Paralysis, Spasticity and Pain

(2011) Gerardo Avila-Martin et al.   PLoS One

Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy

(2011) G. Barcelo-Coblijn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Constitutive exposure of phosphatidylserine on viable cells

(2011) K. Segawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lateral sorting in model membranes by cholesterol-mediated hydrophobic matching

(2011) H.-J. Kaiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Lipid Polymorphisms and Membrane Shape

(2011) V. A. Frolov et al.   Cold Spring Harbor Perspectives in Biology

Long-term reduction in local inflammation by a lipid raft molecule in atopic dermatitis

(2010) S. Dölle et al.   ALLERGY

Imaging signal transduction during phagocytosis: phospholipids, surface charge, and electrostatic interactions

(2010) Sergio Grinstein   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Lipids and Cholesterol as Regulators of Traffic in the Endomembrane System

(2010) Jennifer Lippincott-Schwartz et al.   Annual Review of Biophysics

A Transcriptional Signature and Common Gene Networks Link Cancer with Lipid Metabolism and Diverse Human Diseases

(2010) Heather A. Hirsch et al.   CANCER CELL

A Comprehensive Comparison of Transmembrane Domains Reveals Organelle-Specific Properties

(2010) Hayley J. Sharpe et al.   CELL

Lipidomics: coming to grips with lipid diversity

(2010) Andrej Shevchenko et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipid raft-targeted therapy in multiple myeloma

(2010) F Mollinedo et al.   ONCOGENE

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

The putative lipid raft modulator miltefosine displays immunomodulatory action in T-cell dependent dermal inflammation models

(2009) Wolfgang Bäumer et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Domains in biological membranes

(2009) Robert Lindner et al.   EXPERIMENTAL CELL RESEARCH

Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy

(2009) Xiang Liu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Lipid-nucleic acids interactions as base for organization and expression of cellular genome

(2009) V. V. Kuvichkin   INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY

Pivotal Advance: Phospholipids determine net membrane surface charge resulting in differential localization of active Rac1 and Rac2

(2009) Marco A. O. Magalhaes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lipid Mediators in the Neural Cell Nucleus: Their Metabolism, Signaling, and Association with Neurological Disorders

(2009) Akhlaq A. Farooqui   NEUROSCIENTIST

2-Hydroxyoleic acid affects cardiomyocyte [Ca2+]i transient and contractility in a region-dependent manner

(2008) Gudrun H. Borchert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Proteins and cholesterol-rich domains

(2008) Richard M. Epand   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

(2008) Arun Radhakrishnan et al.   Cell Metabolism

Membranes: a meeting point for lipids, proteins and therapies

(2008) Pablo V. Escribá et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Thematic Review Series: Sphingolipids.Nuclear sphingolipids: metabolism and signaling

(2008) Robert W. Ledeen et al.   JOURNAL OF LIPID RESEARCH

Lipid Microdomains in Cell Nucleus

(2008) Giacomo Cascianelli et al.   MOLECULAR BIOLOGY OF THE CELL

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

(2008) Hongwu Zheng et al.   NATURE

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oleic acid content is responsible for the reduction in blood pressure induced by olive oil

(2008) S. Teres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE