Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2

Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3

(2018) Tetsuya Kawane et al.   Scientific Reports

Runx2 regulates cranial suture closure by inducing hedgehog, Fgf, Wnt, and Pthlh signaling pathway gene expression in suture mesenchymal cells

(2018) Xin Qin et al.   HUMAN MOLECULAR GENETICS

Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation

(2015) Jianwen Wei et al.   CELL

Core Binding Factor β of Osteoblasts Maintains Cortical Bone Mass via Stabilization of Runx2 in Mice

(2015) Kyung-Eun Lim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cbfb Regulates Bone Development by Stabilizing Runx Family Proteins

(2015) Xin Qin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Loss of Osteoblast Runx3 Produces Severe Congenital Osteopenia

(2015) Omri Bauer et al.   MOLECULAR AND CELLULAR BIOLOGY

Runx2 activity in committed osteoblasts is not essential for embryonic skeletogenesis

(2014) Mitra D. Adhami et al.   CONNECTIVE TISSUE RESEARCH

Mitogen-activated Protein Kinase (MAPK)-regulated Interactions between Osterix and Runx2 Are Critical for the Transcriptional Osteogenic Program

(2014) Natalia Artigas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dlx5 and Mef2 Regulate a Novel Runx2 Enhancer for Osteoblast-Specific Expression

(2014) Tetsuya Kawane et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation

(2014) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

(2014) Xin Zhou et al.   PLoS Genetics

An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout mice

(2013) Takeshi Takarada et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osterix induces Col1a1 gene expression through binding to Sp1 sites in the bone enhancer and proximal promoter regions

(2012) Maria José Ortuño et al.   BONE

The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines

(2012) Claudia M.J. Lucero et al.   JOURNAL OF CELLULAR PHYSIOLOGY

SP7 Inhibits Osteoblast Differentiation at a Late Stage in Mice

(2012) Carolina A. Yoshida et al.   PLoS One

Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects

(2011) Takafumi Maeno et al.   BONE

Differential activation of canonical Wnt signaling determines cranial sutures fate: A novel mechanism for sagittal suture craniosynostosis

(2010) Björn Behr et al.   DEVELOPMENTAL BIOLOGY

Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels

(2010) Christa Maes et al.   DEVELOPMENTAL CELL

Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation

(2010) Masaki Mikasa et al.   JOURNAL OF BONE AND MINERAL METABOLISM

TNF-α's effects on proliferation and apoptosis in human mesenchymal stem cells depend on RUNX2 expression

(2010) Olfa Ghali et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Postnatally induced inactivation of Osterix in osteoblasts results in the reduction of bone formation and maintenance

(2009) Wook-Young Baek et al.   BONE

FGF2-activated ERK Mitogen-activated Protein Kinase Enhances Runx2 Acetylation and Stabilization

(2009) Ok-Jin Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Functional Characterization of ERK/MAPK Phosphorylation Sites in the Runx2 Transcription Factor

(2009) Chunxi Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trafficking, development and hedgehog

(2009) Fiona Simpson et al.   MECHANISMS OF DEVELOPMENT

Positive Regulation of Adult Bone Formation by Osteoblast-Specific Transcription Factor Osterix

(2008) Wook-Young Baek et al.   JOURNAL OF BONE AND MINERAL RESEARCH