Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer’s disease?

A neglected modulator of insulin-degrading enzyme activity and conformation: The pH

(2015) Giuseppe Grasso et al.   BIOPHYSICAL CHEMISTRY

Modulation of insulin degrading enzyme activity and liver cell proliferation

(2015) Olga Pivovarova et al.   CELL CYCLE

Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearancein Vivo

(2015) Timothy B. Durham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired insulin action in the human brain: causes and metabolic consequences

(2015) Martin Heni et al.   Nature Reviews Endocrinology

Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of Aβ by insulin degrading enzyme (IDE) in Alzheimer’s disease

(2015) M. Del Campo et al.   NEUROSCIENCE LETTERS

Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

(2015) Xiaohua Li et al.   Clinical Interventions in Aging

Brain metabolic dysfunction at the core of Alzheimer's disease

(2014) Suzanne M. de la Monte et al.   BIOCHEMICAL PHARMACOLOGY

Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis

(2014) Julie Charton et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Association of insulin degrading enzyme gene polymorphisms with Alzheimer's disease: a meta-analysis

(2014) Huawei Cheng et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

(2014) Juan Pablo Maianti et al.   NATURE

The role of glucagon on type 2 diabetes at a glance

(2014) Amélio F Godoy-Matos   Diabetology & Metabolic Syndrome

Nonsteroidal Selective Androgen Receptor Modulators and Selective Estrogen Receptor β Agonists Moderate Cognitive Deficits and Amyloid-β Levels in a Mouse Model of Alzheimer’s Disease

(2013) Sonia George et al.   ACS Chemical Neuroscience

Sevoflurane alters the expression of receptors and enzymes involved in Aβ clearance in rats

(2013) Y. LIU et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

The Type 2 Diabetes-Associated Gene Ide Is Required for Insulin Secretion and Suppression of  -Synuclein Levels in  -Cells

(2013) P. Steneberg et al.   DIABETES

Hepatic Insulin Clearance Is Closely Related to Metabolic Syndrome Components

(2013) O. Pivovarova et al.   DIABETES CARE

Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice

(2013) Marta Dobarro et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Optimization of Peptide Hydroxamate Inhibitors of Insulin-Degrading Enzyme Reveals Marked Substrate-Selectivity

(2013) Samer O. Abdul-Hay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanisms and effects of curcumin on spatial learning and memory improvement in APPswe/PS1dE9 mice

(2013) Pengwen Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuropep-1 ameliorates learning and memory deficits in an Alzheimer's disease mouse model, increases brain-derived neurotrophic factor expression in the brain, and causes reduction of amyloid beta plaques

(2013) Min-Kyoo Shin et al.   NEUROBIOLOGY OF AGING

Relationship between amyloid-beta and the ubiquitin–proteasome system in Alzheimer’s disease

(2013) Liang Hong et al.   NEUROLOGICAL RESEARCH

Meta-analysis of the insulin degrading enzyme polymorphisms and susceptibility to Alzheimer's disease

(2013) Yunyun Zhang et al.   NEUROSCIENCE LETTERS

Structure Based Discovery of Small Molecules to Regulate the Activity of Human Insulin Degrading Enzyme

(2012) Bilal Çakir et al.   PLoS One

Possible implications of insulin resistance and glucose metabolism in Alzheimer’s disease pathogenesis

(2011) Domenico Bosco et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance

(2011) Samer O. Abdul-Hay et al.   PLoS One

Identification of the Allosteric Regulatory Site of Insulysin

(2011) Nicholas Noinaj et al.   PLoS One

Insulin metabolism in human adipocytes from subcutaneous and visceral depots

(2010) Janet Fawcett et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Changes with Age in the Activities of β-Secretase and the Aβ-Degrading Enzymes Neprilysin, Insulin-Degrading Enzyme and Angiotensin-Converting Enzyme

(2010) J. Scott Miners et al.   BRAIN PATHOLOGY

Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?

(2010) Kawser Akter et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Norepinephrine Promotes Microglia to Uptake and Degrade Amyloid   Peptide through Upregulation of Mouse Formyl Peptide Receptor 2 and Induction of Insulin-Degrading Enzyme

(2010) Y. Kong et al.   JOURNAL OF NEUROSCIENCE

How does diabetes accelerate Alzheimer disease pathology?

(2010) Catrina Sims-Robinson et al.   Nature Reviews Neurology

Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aß, and Alzheimer's Disease

(2010) Minerva M. Carrasquillo et al.   PLoS One

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin

(2010) Malcolm A. Leissring et al.   PLoS One

Non-viral causes of hepatocellular carcinoma

(2010) Wojciech Blonski   WORLD JOURNAL OF GASTROENTEROLOGY

A PPARdelta Agonist Reduces Amyloid Burden and Brain Inflammation in a Transgenic Mouse Model of Alzheimers Disease

(2009) Sergey Kalinin et al.   Current Alzheimer Research

Glucose inhibits the insulin-induced activation of the insulin-degrading enzyme in HepG2 cells

(2009) O. Pivovarova et al.   DIABETOLOGIA

Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes

(2009) Natalia Rudovich et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Neprilysin and Insulin-Degrading Enzyme Levels Are Increased in Alzheimer Disease in Relation to Disease Severity

(2009) James Scott Miners et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The proteasomal system

(2009) Tobias Jung et al.   MOLECULAR ASPECTS OF MEDICINE

Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening

(2009) Christelle Cabrol et al.   PLoS One

Amyloid-Degrading Enzymes as Therapeutic Targets in Alzheimers Disease

(2008) Natalia Nalivaeva et al.   Current Alzheimer Research

Stem cell antigen-1 localizes to lipid microdomains and associates with insulin degrading enzyme in skeletal myoblasts

(2008) Conrad L. Epting et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Somatostatin: A Novel Substrate and a Modulator of Insulin-Degrading Enzyme Activity

(2008) Chiara Ciaccio et al.   JOURNAL OF MOLECULAR BIOLOGY