Review
Immunology
Dennis McGonagle, Abdulla Watad, Kassem Sharif, Charlie Bridgewood
Summary: IL-23 plays a crucial role in spondyloarthritis, with implications in the genetic basis, disease progression and treatment efficacy. However, further studies are necessary to determine the specific effects and mechanisms of IL-23 in different disease sites.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Charlie Bridgewood, Darren Newton, Nicola Bragazzi, Miriam Wittmann, Dennis McGonagle
Summary: The IL-23/IL-17 cytokine axis is associated with spondyloarthropathy (SpA) pattern diseases that target the skin, eye, gut and joints, sharing some common characteristics with Th2 type or allergic diseases but also exhibiting distinct features. These findings suggest a dynamic Th2 and Th17 cytokine counter regulation in vivo in humans.
SEMINARS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chiara E. Geyer, Melissa Newling, Lathees Sritharan, Guillermo R. Griffith, Hung-Jen Chen, Dominique L. P. Baeten, Jeroen den Dunnen
Summary: CRP functions not only as a marker of inflammation, but also directly contributes to inflammation by inducing pro-inflammatory cytokine production. It is relatively unique in its capacity to induce IL-23 production compared to a wide panel of PRR ligands. In the context of sepsis, CRP stimulation combined with PRR ligand stimulation leads to a significant reduction in IL-23 production by monocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Hao Li, Maria G. Tsokos, Rhea Bhargava, Iannis E. Adamopoulos, Hanni Menn-Josephy, Isaac E. Stillman, Philip Rosenstiel, Jarrat Jordan, George C. Tsokos
Summary: The study found that IL-23 can affect renal tubular epithelial cells by inhibiting the expression of IL-23 receptor, increasing the levels of free arginine, suppressing T cell proliferation, and inflammatory cytokine production. The results suggest that renal tubular epithelial cells play an immunosuppressive role in regulating kidney inflammation.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Tobias Russell, Abdulla Watad, Charlie Bridgewood, Hannah Rowe, Almas Khan, Abhay Rao, Peter Loughenbury, Peter Millner, Robert Dunsmuir, Richard Cuthbert, Ala Altaie, Elena Jones, Dennis McGonagle
Summary: The study found that spinal enthesis contains MSCs with different in vitro functionalities, especially in response to IL-17A. IL-17A enhances osteogenesis and CCL20 production, while reducing adipogenesis.
Review
Immunology
Victoria Navarro-Compan, Luis Puig, Silvia Vidal, Julio Ramirez, Mar Llamas-Velasco, Cristina Fernandez-Carballido, Raquel Almodovar, Jose Antonio Pinto, Eva Galindez-Aguirregoikoa, Pedro Zarco, Beatriz Joven, Jordi Gratacos, Xavier Juanola, Ricardo Blanco, Salvador Arias-Santiago, Jesus Sanz Sanz, Ruben Queiro, Juan D. Canete
Summary: The interleukin-17 family plays important roles in chronic inflammation and autoimmunity, controlling bacterial and fungal infections. IL-17A and IL-17F are involved in various immune-mediated inflammatory diseases and can be produced by different cell subtypes, including Th17 cells, gamma delta T cells, and innate lymphoid cells. IL-17A and IL-17F contribute independently to chronic tissue inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Nicolas Congy-Jolivet, Claire Cenac, Jerome Dellacasagrande, Benedicte Puissant-Lubrano, Pol Andre Apoil, Kevin Guedj, Flora Abbas, Sophie Laffont, Sandrine Sourdet, Sophie Guyonnet, Fati Nourhashemi, Jean-Charles Guery, Antoine Blancher
Summary: This study found that there is a higher production of IFN-alpha by pDCs in females compared to males, especially in response to TLR7 or TLR9 stimulation, and this sex bias persists in older age groups. However, the production of IFN-alpha via the STING pathway is similar between sexes and remains stable during aging.
Article
Biochemistry & Molecular Biology
Yanpeng Li, Zhilei Li, Kutty Selva Nandakumar, Rikard Holmdahl
Summary: A recent study found that a single nucleotide variant (NCF1(R90H)) on the NCF1 gene was associated with low production of reactive oxygen species (ROS) and causative for several autoimmune diseases. The study induced psoriasis in the skin and psoriatic arthritis using mannan and evaluated the effects. It was found that the NCF1(90H) variant promoted psoriasis and psoriatic arthritis by hyperactivating macrophages, expanding keratinocytes, and increasing numbers of γδT17 cells.
Article
Critical Care Medicine
QiXing Chen, Yang Yang, XiaoLiang Wu, ShiYue Yang, Yan Zhang, Qiang Shu, XiangMing Fang
Summary: The study found that TREM-2 can prolong the survival of elderly septic patients by regulating the IL-23/IL-17A immune pathway, providing new therapeutic targets in sepsis.
Article
Immunology
Andre Lopes Saraiva, Raphael Sanches Peres, Flavio Protasio Veras, Jhimmy Talbot, Kalil Alves de Lima, Joao Paulo Mesquita Luiz, Thiago Mattar Cunha, Paulo Louzada-Junior, Fernando Queiroz Cunha, Jose Carlos Alves-Filho
Summary: The experimental arthritis model established using citrullinated human plasma fibrinogen revealed the importance of IL-23/IL-17 immune axis-mediated inflammatory responses in the pathogenesis of rheumatoid arthritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Quentin Philippot, Masato Ogishi, Jonathan Bohlen, Julia Puchan, Andres Augusto Arias, Tina Nguyen, Marta Martin-Fernandez, Clement Conil, Darawan Rinchai, Mana Momenilandi, Seyed Alireza Mandaviani, Mohammad Keramatipour, Jeremie Rosain, Rui Yang, Taushif Khan, Anna-Lena Neehus, Marie Materna, Ji Eun Han, Jessica Peel, Federico Mele, Marc Weisshaar, Sandra Jovic, Paul Bastard, Romain Levy, Tom Le Voyer, Peng Zhang, Majistor Raj Luxman Maglorius Renkilaraj, Carlos A. Arango-Franco, Simon Pelham, Yoann Seeleuthner, Mathieu Pochon, Manar Mahmoud Ahmad Ata, Fatima Al Ali, Melanie Migaud, Camille Soudee, Tatiana Kochetkov, Anne Molitor, Raphael Carapito, Seiamak Bahram, Bertrand Boisson, Claire Fieschi, Davood Mansouri, Nico Marr, Satoshi Okada, Mohammad Shahrooei, Nima Parvaneh, Zahra Chavoshzadeh, Aurelie Cobat, Dusan Bogunovic, Laurent Abel, Stuart G. Tangye, Cindy S. Ma, Vivien Beziat, Federica Sallusto, Stephanie Boisson-Dupuis, Jacinta Bustamante, Jean-Laurent Casanova, Anne Puel
Summary: Patients with IL-23R deficiency may suffer from Mendelian susceptibility to mycobacterial disease and chronic mucocutaneous candidiasis. IL-23 is essential for the production of IL-17A in MATT cells and for the production of IFN-y in both V62+ y6 T cells and MATT cells.
SCIENCE IMMUNOLOGY
(2023)
Article
Immunology
Masashi Kanayama, Yuta Izumi, Megumi Akiyama, Toyoki Hayashi, Koji Atarashi, Axel Roers, Taku Sato, Toshiaki Ohteki
Summary: Emergency myelopoiesis is a hematopoietic response against systemic infections, but the role of lymphocytes in this process has not received much attention. This study found that a unique B cell subset expressing myeloid markers emerged in the bone marrow during emergency myelopoiesis, and these cells preferentially expressed IL-10, which stimulated hematopoietic progenitors for enhanced myeloid differentiation. Blocking IL-10 significantly suppressed emergency myelopoiesis and hindered microbial clearance in a model of cecal ligation and puncture. These findings suggest the importance of adaptive immune cells in boosting emergency myelopoiesis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Sarah K. Whitley, Mushi Li, Sakeen W. Kashem, Toshiro Hirai, Botond Z. Igyarto, Kelley Knizner, Jonhan Ho, Laura K. Ferris, Casey T. Weaver, Daniel J. Cuas, Mandy J. McGeachy, Daniel H. Kaplan
Summary: This study demonstrates the importance of locally produced IL-23 in promoting in situ proliferation of cutaneous TRM17 cells, supporting their longevity and function. Anti-IL-23 therapy effectively reduces the number of TRM17 cells in the skin, which has significant implications for the treatment of psoriasis.
SCIENCE IMMUNOLOGY
(2022)
Article
Microbiology
Bhawna Yadav, Charles A. Specht, Chrono K. Lee, Maria Pokrovskii, Jun R. Huh, Dan R. Littman, Stuart M. Levitz
Summary: Exposure to mold, Aspergillus, is generally harmless to healthy individuals but can lead to invasive and allergic aspergillosis in immunocompromised and atopic individuals. In murine models of pulmonary aspergillosis, lung eosinophils express IL-17, ROR gamma t, and IL-23R. However, IL-23 is not necessary for the production of IL-17 and ROR gamma t in this context.
Article
Chemistry, Applied
Yuxi Jin, Huanxian Cui, Xiaoya Yuan, Lu Liu, Xiaojing Liu, Yongli Wang, Jiqiang Ding, Hai Xiang, Xinxiao Zhang, Jianfeng Liu, Hua Li, Guiping Zhao, Jie Wen
Summary: The study analyzed the volatile organic compounds in chicken meat from 972 Chinese local chickens and identified various VOCs belonging to aldehyde, alcohol, and alkane classes. The breeds with the highest total aldehyde content were negatively correlated with the content of the other two classes, and their flavor could be distinguished by E-nose. Additionally, 9 common VOCs were shared by different breeds, and principal component analysis identified hexanal and 1-octen-3-ol as the major VOCs in each breed based on different criteria.
Article
Rheumatology
Charlie Bridgewood, Kassem Sharif, Jane Freeston, Benazir Saleem, Tobias Russell, Abdulla Watad, Almas Khan, Peter Loughenbury, Abhay Rao, Miriam Wittmann, Dennis McGonagle
Summary: The study revealed a protective role of IL-4/IL-13 in regulating the IL-23-IL-17 axis, reducing production of IL-23 in entheses and inhibiting CCL20 secretion in entheseal fibroblasts in patients with arthritis. IL-4/IL-13 were also detected in synovial fluid of PsA patients, implying a potential link to the pathogenesis of PsA.
Article
Multidisciplinary Sciences
Weichao Zhai, Jerome Tan, Tobias Russell, Sixun Chen, Dennis McGonagle, May Win Naing, Derrick Yong, Elena Jones
Summary: The study investigates alternative methods for quantifying the senescence of hMSCs, aiming to increase the final output of therapeutic-grade hMSC cultures. The advanced flow cytometry and autofluorescence methods show statistically significant values and good fold difference ranges between early and senescent passage hMSCs, providing a label-free approach for evaluating cellular senescence in hMSCs.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
S. R. Harrison, J. R. L. Klassen, C. Bridgewood, A. Scarsbrook, H. Marzo-Ortega, D. McGonagle
Summary: In 2020, 32.8% of ambulatory patients with suspected pulmonary embolism presenting with chest pain exhibited parenchymal changes, with 7.5% diagnosed as COVID-19 infection based on imaging criteria, despite the absence of other COVID-19 symptoms.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Rheumatology
Dennis McGonagle, Athimalaipet Ramanan, Charlie Bridgewood
Summary: This article discusses macrophage activation syndrome (MAS) in relation to other cytokine storm scenarios, providing a framework for understanding MAS within the spectrum of innate and adaptive immunity in the context of gain or loss of immune function.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Review
Immunology
Tobias Russell, Charlie Bridgewood, Hannah Rowe, Ala Altaie, Elena Jones, Dennis McGonagle
Summary: In AS and nrAxSpA, spinal inflammation may lead to excessive entheseal tissue repair and new bone formation, involving local tissue immune responses and cytokines like TNF and IL-17. Normal skeletal homeostasis involves tissue microdamage, micro-inflammation, and repair, with resident immune cells capable of regulating tissue repair. Genetic studies and animal models suggest redundant roles for TNF and IL-17 in physiological tissue repair, but in diseases like AS, immune system overactivity of these cytokines can lead to exuberant tissue repair responses.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Editorial Material
Dermatology
Lennart M. Roesner, Charlie Bridgewood, Dennis McGonagle, Miriam Wittmann
Summary: In a new article, Bakker et al. (2021) demonstrate how dupilumab specifically targets skin-homing T cells, the key cells in atopic dermatitis, using deep immune cell phenotyping.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Health Care Sciences & Services
Elizabeth Cook, Arabella Scantlebury, Alison Booth, Emma Turner, Arun Ranganathan, Almas Khan, Sashin Ahuja, Peter May, Amar Rangan, Jenny Roche, Elizabeth Coleman, Catherine Hilton, Belen Corbacho, Catherine Hewitt, Joy Adamson, David Torgerson, Catriona McDaid
Summary: The feasibility study comparing surgical fixation with conservative treatment for stable thoracolumbar fractures without spinal cord injury showed a slightly lower recruitment rate than anticipated, with patients expressing a strong preference for surgical treatment. Key themes included the lack of clinical consensus on eligibility criteria implementation and lack of equipoise regarding treatment options.
HEALTH TECHNOLOGY ASSESSMENT
(2021)
Article
Dermatology
Charlie Bridgewood, Miriam Wittmann, Tom Macleod, Abdulla Watad, Darren Newton, Kanchan Bhan, Howard Amital, Giovanni Damiani, Sami Giryes, Nicola Luigi Bragazzi, Dennis McGonagle
Summary: The use of Dupilumab is associated with seronegative inflammatory arthritis and psoriasis, but not with classic polygenic humoral autoimmune diseases. Pathway analysis suggests that Dupilumab may affect certain cytokine pathways and contribute to immune disorders and other pathological processes.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Dermatology
Lucy M. Carter, Dennis McGonagle, Edward M. Vital, Miriam Wittmann
Summary: Insights into early interventions in autoimmune diseases can improve long-term outcomes, and the optimal window of opportunity may extend into asymptomatic preclinical phases.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Clinical Neurology
James F. M. Meaney, James S. O'Donnell, Charles Bridgewood, Joseph Harbison, Dennis McGonagle
Summary: Neurological manifestations, particularly strokes, are common in COVID-19, and a novel mechanism suggests that pulmonary vein clots can embolize to the brain, leading to large vessel occlusion strokes.
Review
Medicine, Research & Experimental
Tom Macleod, Charles Bridgewood, Isabel Hyde, Megan Heague, Philip Helliwell, Martin Stacey, Miriam Wittmann
Summary: This review focuses on the molecular and cellular mechanisms of psoriatic inflammation, exploring the connections between different manifestations in the skin and musculoskeletal compartments. The importance of inflammatory feedback loops and the interaction between the epidermis and immune compartments in driving psoriatic inflammation are emphasized. Additionally, the review highlights the use of biomarkers for predicting therapy outcomes and the transition from psoriasis to psoriatic arthritis.
Editorial Material
Dermatology
Miriam Wittmann, Petra Staubach, Dennis McGonagle
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Rheumatology
Antonios Psarras, Miriam Wittmann, Edward M. Vital
Summary: This review discusses the role and therapeutic application of type I interferons in the pathogenesis of systemic lupus erythematosus (SLE). Recent evidence has overturned long-held assumptions about the regulation and pathological mechanisms of interferons, providing a new perspective on SLE pathogenesis. The study also highlights the importance of type I interferons in the early stages of the disease and non-haematopoietic cellular sources. These findings suggest the potential of interferon-blocking therapies for treating SLE.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Review
Dermatology
Johannes Pawlowski, Janina Beczinski, Henner Stege, Caroline Mann, Florian Butsch, Bilal Al-Nawas, Sebahat Kaya, Miriam Wittmann
Summary: Lichen planus is a complex dermatological condition that affects the skin, nails, and mucosa. The exact cause is still unclear and treatment options are limited. Severe oral mucosal involvement is challenging to manage and requires regular screening for potential cancer development.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)