The Enigmatic Protein Kinase C-eta

The dynamic nature of senescence in cancer

(2018) Soyoung Lee et al.   NATURE CELL BIOLOGY

Differential effects of protein kinase C-eta on apoptosis versus senescence

(2018) Alakananda Basu et al.   CELLULAR SIGNALLING

PRKCH regulates hematopoietic stem cell function and predicts poor prognosis in acute myeloid leukemia

(2017) Shaina N. Porter et al.   EXPERIMENTAL HEMATOLOGY

The Role of Kinase Modulators in Cellular Senescence for Use in Cancer Treatment

(2017) Chang Lee et al.   MOLECULES

To clear, or not to clear (senescent cells)? That is the question

(2016) Amaia Lujambio   BIOESSAYS

miR-24-3p Suppresses Malignant Behavior of Lacrimal Adenoid Cystic Carcinoma by Targeting PRKCH to Regulate p53/p21 Pathway

(2016) Ming-xue Zhang et al.   PLoS One

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

PKCη is an anti-apoptotic kinase that predicts poor prognosis in breast and lung cancer: Figure 1

(2014) Udi Zurgil et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Silencing of PKCη induces cycle arrest of EBV+ B lymphoma cells by upregulating expression of p38-MAPK/TAp73/GADD45α and increases susceptibility to chemotherapeutic agents

(2014) Ga Bin Park et al.   CANCER LETTERS

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

The unique protein kinase Cη: Implications for breast cancer (Review)

(2014) DEEPANWITA PAL et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia

(2014) L. Ma et al.   Science Translational Medicine

PKCη promotes senescence induced by oxidative stress and chemotherapy

(2014) U Zurgil et al.   Cell Death & Disease

Upregulation of PKCη by PKCε and PDK1 involves two distinct mechanisms and promotes breast cancer cell survival

(2013) Deepanwita Pal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Novel regulation of protein kinase C-η

(2012) Deepanwita Pal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PKCη is a negative regulator of AKT inhibiting the IGF-I induced proliferation

(2012) Galit Shahaf et al.   EXPERIMENTAL CELL RESEARCH

Protein kinase Cη activates NF-κB in response to camptothecin-induced DNA damage

(2011) Hadas Raveh-Amit et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduced proliferation and enhanced migration: Two sides of the same coin? Molecular mechanisms of metastatic progression by YB-1

(2011) Valentina Evdokimova et al.   CELL CYCLE

Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation

(2011) Yasuhito Shirai et al.   MOLECULAR BIOLOGY OF THE CELL

PKCη promotes a proliferation to differentiation switch in keratinocytes via upregulation of p27Kip1 mRNA through suppression of JNK/c-Jun signaling under stress conditions

(2011) T Hara et al.   Cell Death & Disease

Protein kinase C δ and η differently regulate the expression of loricrin and Jun family proteins in human keratinocytes

(2010) Nagisa Kamioka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PKCη confers protection against apoptosis by inhibiting the pro-apoptotic JNK activity in MCF-7 cells

(2009) Noa Rotem-Dai et al.   EXPERIMENTAL CELL RESEARCH

Activation of Protein Kinase Cη by Type I Interferons

(2009) Amanda J. Redig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysing the expression of protein kinase C eta in human hepatocellular carcinoma

(2009) Hsiu-Chin Lu et al.   PATHOLOGY