期刊
BEHAVIOURAL BRAIN RESEARCH
卷 229, 期 1, 页码 265-272出版社
ELSEVIER
DOI: 10.1016/j.bbr.2012.01.007
关键词
Glutamate receptor; GluA3; Striatum; Dopamine; Serotonin; Olfactory bulb; Aggression; Sociability; Social interaction; Mice
资金
- March of Dimes Foundation
- NICHD [HD044789, HD052680]
- Ministry of Education and Science of Spain
- Grants-in-Aid for Scientific Research [22300122] Funding Source: KAKEN
Glutamate signaling has been implicated in the regulation of social behavior. AMPA-glutamate receptors are assembled from four subunits (GluA1-4) of mainly GluA1/2 and GluA2/3 tetramers that form ion channels of distinct functional properties. Mice lacking GluA1 showed a reduced anxiety and male aggression. To understand the role of GluA3 in modulating social behavior, we investigated GluA3-deficient mice (Gria3 -/Y) on C57BL/6J background. Compared to wild type (WT) littermates (n = 14), Gria3 -/Y mice (n = 13) showed an increase in isolation-induced male aggression (p = 0.011) in home cage resident-intruder test; an increase in sociability (p = 0.01), and increase in male-male social interactions in neutral arena (p = 0.005); an increase in peripheral activities in open field test (p = 0.037) with normal anxiety levels in elevated plus maze and light-dark box; and minor deficits in motor and balance function in accelerating rotarod test (p = 0.016) with normal grip strength. Gria3 -/Y mice showed no significant deficit in spatial memory function in Morris-water maze and Y-maze tests, and normal levels of testosterone. Increased dopamine concentrations in stratum (p = 0.034) and reduced serotonin turnover in olfactory bulb (p = 0.002) were documented in Gria3 -/Y mice. These results support a role of GluA3 in the modulation of social behavior through brain dopamine and/or serotonin signaling and different AMPA receptor subunits affect social behavior through distinct mechanisms. (C) 2012 Elsevier B.V. All rights reserved.
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